作用钾通道Kv1.3免疫抑制多肽药物的发现、功能与优化

81630091
2016
H34.药物学
吴英亮
重点项目
教授
武汉大学
275万元
结构与功能关系;钾通道Kv1.3;结构优化;自身免疫性疾病;免疫抑制多肽
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The rapid development of the first instar telson with venom secretion highlights the remarkable survival ability of scorpions 期刊论文 Songryong Li;Unchol Ri;Chenhu Qin;Yiyuan Guo;Changho Ri;Wenxin Li;Zhijian Cao;Yingliang Wu
2 Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1 期刊论文 Zeng Z;Zhang R;Hong W;Cheng Y;Wang H;Lang Y;Ji Z;Wu Y;Li W;Xie Y;Cao Zhijian（项目组成员）
3 酸性氨基酸扫描法设计的免疫抑制多肽及应用 专利 吴英亮;曹志贱;李文鑫
4 靶向钾离子通道Kv1.3活性多肽的分子设计及制备与应用 专利 李文鑫;吴英亮;曹志贱;陈宗运;韩松
5 Mouse β-Defensin 3, A Defensin Inhibitor of Both Its Endogenous and Exogenous Potassium Channels 期刊论文 Zhang Y;Zhao Y;Liu H;Yu W;Yang F;Li W;Cao Z;Wu Y
6 Treating autoimmune disorders with venom-derived peptides 期刊论文 Bingzheng Shen;Zhijian Cao;Wenxin Li;Jean-Marc Sabatier;Yingliang Wu
7 Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors 期刊论文 Xueke Li;Haifeng Yang;Yuewen Han;Shijin Yin;Bingzheng Shen;Yingliang Wu;Wenxin Li;Zhijian Cao
8 Scorpion toxin-potassium channel interaction law and its applications 期刊论文 Zheng Zuo;Zongyun Chen;Zhijian Cao;Wenxin Li;Yingliang Wu
9 Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes 期刊论文 Yonghui Zhao;Zongyun Chen;Zhijian Cao;Wenxin Li;Yingliang Wu
10 Expression of recombinant α-toxin BmKM9 from scorpion Buthus martensii Karsch and its functional characterization on sodium channels 期刊论文 Fan Yang;Shuang Liu;Yaoyun Zhang;Chenhu Qin;Lingna Xu;Wenhua Li;Zhijian Cao;Wenxin Li;Yingliang Wu
11 Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine 期刊论文 Fan Yang;Danya Wang;Yongjia Tong;Chenghu Qin;Liuting Yang;Fei Yu;Xin Huang;Shuang Liu;Zhijian Cao;Lin Guo;Wenxin Li;Yingliang Wu;Xiaolu Zhao
12 Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions 期刊论文 Lanxia Meng;Yonghui Zhao;Daliang Qu;Zili Xie;Xingchen Guo;Zhanyong Zhu;Zongyun Chen;Longhua Zhang;Wenxin Li;Zhijian Cao;Changlin Tian;Yingliang Wu
13 Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions 期刊论文 Zhao Y;Xie Z;Feng J;Li W;Cao Z;Wu Y
14 蝎活性肽ADP-7及其应用 专利 吴英亮;曹志贱
15 Different pharmacological properties between scorpion toxin BmKcug2 and its degraded analogs highlight the diversity of K+ channel blockers from thermally processed scorpions 期刊论文 Chenhu Qin;Xiuping Wan;Songryong Li;Fan Yang;Liuting Yang;Zheng Zuo;Zhijian Cao;Zongyun Chen;Yingliang Wu
16 Molecular characterization and expression analysis of CSαβ defensin genes from the scorpion Mesobuthus martensii 期刊论文 Lang Y;Pi X;Di Z;Zhang Q;Wang H;Shen B;Li F;Liu G;Yu Y;Li X;Wu Y;Li W;Cao Zhijian（项目组成员）
17 BmK86-P1, a New Degradation Peptide with Desirable Thermostability and Kv1.2 Channel-Specific Activity from Traditional Chinese Scorpion Medicinal Material 期刊论文 Chenhu Qin;Xuhua Yang;Zheng Zuo;Liuting Yang;Fan Yang;Zhijian Cao;Zongyun Chen;Yingliang Wu
18 Defensins, a novel type of animal toxin-like potassium channel inhibitor 期刊论文 Zhao Y;Chen Z;Cao Z;Li W;Wu Y
19 Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant gram-positive bacteria 期刊论文 Liu G;Yang F;Li F;Li Z;Lang Y;Shen B;Wu Y;Li W;Harrison PL;Strong PN;Xie Y;Miller K;Cao Zhijian（项目组成员）
20 A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles 期刊论文 Li F;Lang Y;Ji Z;Xia Z;Han Y;Cheng Y;Liu G;Sun F;Zhao Y;Gao M;Chen Z;Wu Y;Li W;Cao Zhijian（项目组成员）
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