人Tau蛋白纤维结构传递的机制研究

31570779
2015
C0505.蛋白质、多肽与酶生物化学
梁毅
面上项目
教授
武汉大学
65万元
多肽;蛋白质;错误折叠;折叠病;蛋白质聚集
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111 期刊论文 Wen-Chang Xu;Jin-Zhao Liang;Cheng Li;Zhi-Xin He;Han-Ye Yuan;Ben-Yan Huang;Xiao-Ling Liu;Bo Tang;Dai-Wen Pang;Hai-Ning Du;Yi Yang;Jie Chen;Lei Wang;Min Zhang;Yi Liang
2 Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells 期刊论文 Ji-Ying Hu;De-Lin Zhang;Xiao-Ling Liu;Xue-Shou Li;Xiao-Qing Cheng;Jie Chen;Hai-Ning Du;Yi Liang
3 Macromolecular crowding favors the fibrillization of β2-microglobulin by accelerating the nucleation step and inhibiting fibril disassembly 期刊论文 Xu-Dong Luo;Fan-Lou Kong;Hai-Bin Dang;Jie Chen;Yi Liang
4 蛋白质二硫键异构酶对Tau蛋白相分离及细胞毒性的调控 会议论文 王侃;刘嘉琪;梁毅
5 Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells 会议论文 Ji-Ying Hu;De-Lin Zhang;Xiao-Ling Liu;Xiao-Qing Cheng;Jie Chen;Yi Liang
6 Neutralizing mutations significantly inhibit amyloid formation by human prion protein and decrease its cytotoxicity 期刊论文 Jun-Jie Huang;Xiang-Ning Li;Wan-Li Liu;Han-Ye Yuan;Yuan Gao;Kan Wang;Bo Tang;Dai-Wen Pang;Jie Chen;Yi Liang
7 Environment-sensitive near-infrared probe for fluorescent discrimination of Abeta and Tau fibrils in AD brain 期刊论文 Kaixiang Zhou;Chang Yuan;Bin Dai;Kan Wang;Yimin Chen;Denglei Ma;Jiapei Dai;Yi Liang;Hongwei Tan;Mengchao Cui
8 Zinc Enhances the Formation of Liquid and Hydrogel Phases of Human Tau and thereby Increases Tau Toxicity in Neuronal Cells 会议论文 Ying-Ying Gao;Yi Liang
9 Novel D-A-D based near-infrared probes for the detection of beta-amyloid and Tau fibrils in Alzheimer's disease 期刊论文 Yuying Li;Kan Wang;Kaixiang Zhou;Wentao Guo;Bin Dai;Yi Liang;Jiapei Dai;Mengchao Cui
10 N端六肽缺失导致β2-微球蛋白形成不同株形淀粉样纤维 会议论文 党海滨;罗旭东;高莹莹;陈杰;梁毅
11 蛋白质二硫键异构酶对Tau蛋白相分离及细胞毒性的调控 会议论文 梁毅
12 Zinc regulates the misfolding and toxicity of human Tau protein associated with Alzheimer disease 会议论文 Ji-Ying Hu;Ying-Ying Gao;Yan Zeng;De-Lin Zhang;Xiao-Ling Liu;Jie Chen;Hai-Ning Du;Yi Liang
13 Zinc significantly changes the aggregation pathway and the conformation of aggregates of human prion protein 会议论文 Kai Pan;Chuan-Wei Yi;Jie Chen;Yi Liang
14 Tau蛋白积聚及致病机制研究进展 会议论文 梁毅
15 N-linked glycosylation significantly changes the subcellular localization and aggregation of human prion protein 会议论文 Chuan-Wei Yi;Jun-Jie Huang;Li-Qiang Wang;Kai Pan;Jie Chen;Yi Liang
16 脑脊液中次磺酸化修饰的SOD1作为散发型ALS早期诊断的潜在标志物 专利 梁毅;徐文倡;何志欣;谭晓霞;袁菡烨;王利强;陈杰
17 兔、犬、马抵御朊病毒疾病的研究进展 期刊论文 高原;陈杰;梁毅
18 次磺酸化修饰在渐冻症致病机制中的作用 会议论文 袁菡烨;梁毅
19 Synthesis and bioevaluation of technetium-99 m / rhenium labeled phenylquinoxaline derivatives as Tau imaging probes 期刊论文 Fan Yang;Kan Wang;Kaixiang Zhou;Bin Dai;Jiapei Dai;Yi Liang;Mengchao Cui
20 次磺酸化修饰对SOD1致病结构形成的调控 会议论文 徐文倡;李成;何志欣;袁菡烨;王侃;陈杰;梁毅
21 Pathological H2O2 triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111 会议论文 Wen-Chang Xu;Han-Ye Yuan;Zhi-xin He;Jie Chen;Yi Liang
22 Glycosylation significantly inhibits the aggregation of human prion protein and decreases its cytotoxicity 期刊论文 Chuan-Wei Yi;Li-Qiang Wang;Jun-Jie Huang;Kai Pan;Jie Chen;Yi Liang
23 Both glycosylation modification and GPI anchor can affect the subcellular localization of human prion protein 会议论文 Chuan-Wei Yi;Jun-Jie Huang;Li-Qiang Wang;Jie Chen;Yi Liang
24 一种保护性人朊蛋白G127I突变体及其构建方法 专利 梁毅;黄俊杰;易传伟;高原;王利强;陈杰
25 小分子化合物抑制人朊蛋白错误折叠的机制研究 会议论文 王利强;梁毅
26 Valine 127 is very important for amyloid fibril formation of human prion protein 会议论文 Jun-Jie Huang;Chuan-Wei Yi;Jie Chen;Yi Liang
27 Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111 会议论文 Wen-Chang Xu;Cheng Li;Han-Ye Yuan;Zhi-Xin He;Jie Chen;Yi Liang
查看更多信息请先登录或注册

相关项目

趋势报告

经验分享