【30830112】胎海马GR介导外源物所致HPA轴发育异常的表观遗传机制国家自然基金项目

胎海马GR介导外源物所致HPA轴发育异常的表观遗传机制

项目批准号： 30830112

批准年份： 2008

学科分类： H3512.药物毒理

项目负责人：汪晖

资助类别：重点项目

负责人职称：教授

依托单位：武汉大学

资助金额： 160万元

关键词：海马;外源物;表观遗传修饰;下丘脑-垂体-肾上腺轴;糖皮质激素受体

起止时间： 2009-01-01到2012-12-31

中英文摘要
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项目成果
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序号	标题	类型	作者
1	胎儿生长受限的神经内分泌机制研究进展	期刊论文	刘莲\|何雯雯\|汪晖\|
2	Pyrrolizidine alkaloids induce fetal developmental toxicities in mice	会议论文	Kou H\|Guo Y\|Xiong J\|Ma ZG\|Zheng J\|Wang H\|
3	NMR代谢组学技术探寻尼古丁所致IUGR母鼠血浆中一组早期候选生物标志物	会议论文	鄢友娥\|刘岩松\|梁赅\|冯江华\|何雯雯\|黄晶\|胡洁琼\|汪晖\|
4	Nicotine induces a single CpG methylation within the StAR promoter region leading to reduced gene expression and cortisol/dehydroepiandrosterone production	会议论文	Wang TT\|Chen M\|Chen HY\|Wang H\|Feng YH\|
5	Placental Dysfunctions in Intrauterine Growth Retardation-induced by Smoking and Alcohol Drinking and Effect of Sodium Ferulate	会议论文	Yan YE\|Li Y\|Wang H\|
6	孕期咖啡因暴露所致IUGR仔鼠成年后血脂代谢紊乱的胎儿发育机制	会议论文	汪晖\|徐丹\|梁赅\|平洁\|刘岩松\|鄢友娥\|刘芳\|
7	吡咯西啶双烷生物碱所致的胎儿发育毒性研究	会议论文	寇皓\|郭喻\|熊婕\|马振国\|郑江\|汪晖\|
8	孕期尼古丁暴露所致成年雌性大鼠脂肪肝易感的宫内代谢编程机制	会议论文	沈朗\|平洁\|吴勇\|张郦\|刘岩松\|刘莲\|鄢友娥\|汪晖\|
9	Changes of multiple biotransformation phase I and phase II enzyme activities in human fetal adrenals during fetal development	期刊论文	Wang H\|Ping J\|Peng RX\|Yue J\|Xia XY\|Li QX\|Kong R\|Hong JY\|
10	Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production	期刊论文	Wang TT\|Chen M\|Liu L\|Cheng HY\|Yan YE\|Feng YH\|Wang H\|
11	Prenatal nicotine exposure induced a hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in IUGR offspring rats	期刊论文	Liu L\|Liu F\|Kou H\|Zhang BJ\|Xu D\|Chen B\|Chen LB\|Magdalou J\|Wang H\|
12	孕期咖啡因暴露所致子代HPA轴高应激敏感性增加高脂饮食下胰岛素抵抗发生的风险	会议论文	张郦\|汪晖\|
13	一个理想未来:转化医学用于宫内发育迟缓早期筛查诊断	会议论文	汪晖\|鄢友娥\|平洁\|
14	咖啡因所致IUGR胎儿HPA轴发育异常：基于海马GR的表达调控改变	会议论文	汪晖\|徐丹\|
15	A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion.	期刊论文	Xu D\|Zhang C\|Chen LB\|Magdalou J\|Wang H\|Wu Y\|Liu F\| Liu YS\|Shen L\|Lei YY\|Liu J\|Ping J\|Qin J\|
16	宫内发育迟缓母鼠血、胎鼠血及羊水的NMR代谢组学研究	会议论文	刘岩松\|鄢友娥\|梁赅\|平洁\|汪晖\|
17	Prenatal nicotine exposure potentiated high-fat diet-induced pancreatic islet dysfunction in rat offspring	会议论文	Guo Y\|Zhang L\|Shen L\|Kou H\|Shi C\|Wang H\|
18	表观遗传修饰在胚胎发育过程中的调控作用研究进展	期刊论文	刘瑾\|汪晖\|张本坚\|王婷婷\|平洁\|
19	胎肾上腺 StAR 介导咖啡因致胎儿发育毒性的分子机制	奖励	平洁\|王婷婷\|冯映红\|汪晖\|
20	咖啡因致胎儿宫内发育迟缓机制的研究进展	期刊论文	周书\|黄晶\|鲍冲\|平洁\|汪晖\|
21	Testosterone-Metabolizing Capacity and Characteristics of Adrenal Microsomes in Human Fetus In Vitro	期刊论文	Wang H\|Xu D\|Peng RX\|Yue J\|
22	咖啡因摄入所致胎血高糖皮质激素可引起血浆代谢谱及胰岛素抵抗相关糖、脂代谢通路的变化	会议论文	刘岩松\|徐丹\|鄢友娥\|梁赅\|汪晖\|
23	外源物(药物)所致胎儿发育毒性及机制的研究进展	会议论文	汪晖\|
24	The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro	期刊论文	Deng Y\|Chen B\|Qi YJ\|Magdalou J\|Wang H\|Chen LB\|
25	Intrauterine origin of caffeine-induced high susceptibility to adult metabolic syndrome: Alleviated glucocorticoid inactivation alters the neuroendocrine metabolic programming of fetal rats	会议论文	Xu D\|Zhang BJ\|Ping J\|Liang G\|Liu F\|Kou H\|Li XJ\|Lei YY\|Wang H\|
26	Dysplasia of Hypothalamic-pituitary-adrenal Axis in Caffeine-induced Rat Intrauterine Growth Retardation: Based on an Up-regulated Expression of Glucocorticoid Receptor in Hippocampus	会议论文	Xu D\|He WW\|Liang G\|Zhang BJ\|Ping J\|Liu F\|Wang H\|
27	Caffeine induced a single CpG demethylation within the StAR promoter region leading to increased gene expression	会议论文	Ping J\|Wang TT\|Feng YH\|Wang H\|
28	Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure	期刊论文	Li Y\|Yan YE\|Wang H\|
29	Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells	期刊论文	Ping J\|Lei YY\|Liu L\|Wang TT\|Feng YH\|Wang H\|
30	转化医学用于外源物所致宫内发育迟缓的临床早期诊断	期刊论文	刘岩松\|汪晖\|
31	Caffeine-Induced Activated Glucocorticoid Metabolism in the Hippocampus Causes Hypothalamic-Pituitary-Adrenal Axis Inhibition in Fetal Rats	期刊论文	Xu D\|Magdalou J\|Wang H\|Zhang BJ\|Liang G\|Ping J\|Kou H\|Li XJ\|Xiong J\|Hu DC\|Chen LB\|
32	Toxic Effect and Neuroendocrine Mechanism of Caffeine on Fatal Development in Pregnant Rats	会议论文	Liang G\|Xu D\|He WW\|Zhang BJ\|Wang H\|
33	Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents	期刊论文	Huang J\|Zhou S\|Ping J\|Pan XL\|Liang G\|Xu D\|Kou H\|Bao C\|Wang H\|
34	Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice	期刊论文	Liang G\|Chen M\|Pan XL\|Zheng J\|Wang H\|
35	Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways	期刊论文	Liu YS\|Magdalou J\|Wang H\|Xu D\|Feng JH\|Kou H\|Liang G\|Yu H\|He XH\|Zhang BF\|Chen LB\|
36	Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation	期刊论文	Tan Y\|Chen LB\|Wang H\|Liu J\|Deng Y\|Cao H\|Xu D\|Cu F\|Lei Y\|Magdalou J\|Wu M\|
37	Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic alterations in fetal rats	期刊论文	Xu D\|Liang G\|Yan YE\|He WW\|Liu YS\|Chen LB\|Magdalou J\|Wang H\|
38	孕期咖啡因摄入所致IUGR胎鼠肝脏IGF-1基因的表达抑制及表观遗传修饰改变	会议论文	刘瑾\|徐丹\|刘莲\|杨明锐\|平洁\|汪晖\|
39	Growth Retardation of Fetal Rats Exposed to Nicotine In Utero: Possible Involvement of CYP1A1, CYP2E1, and P-Glycoprotein	期刊论文	Wang T\|Chen M\|Yan YE\|Xiao FQ\|Pan XL\|Wang H\|
40	Prenatal Alcohol Exposure Potentiated High-fat Diet-induced Hepatosteatosis of IUGR Adult Offspring In a Sex-specific Manner	会议论文	Shen L\|Liu ZF\|Wang LL\|Zhang L\|Wang H\|
41	孕期外源物暴露所致宫内发育迟缓的神经内分泌代谢编程机制	会议论文	汪晖\|
42	咖啡因所致 IUGR 胎儿 HPA 轴发育异常：基于海马 GR 的表达调控改变	奖励	徐丹\|汪晖\|
43	Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function	期刊论文	Xu D\|Chen M\|Pan XL\|Xia LP\|Wang H\|
44	咖啡因所致IUGR胎儿HPA轴发育异常：基于海马GR的表达调控改变	会议论文	汪晖\|徐丹\|

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