【81201176】基质金属蛋白酶响应性高分子胶束的制备及其在肿瘤药物或基因治疗上的应用国家自然基金项目

基质金属蛋白酶响应性高分子胶束的制备及其在肿瘤药物或基因治疗上的应用

项目批准号： 81201176

批准年份： 2012

学科分类： H2809.医用生物材料与仿生材料

项目负责人：葛治伸

资助类别：青年科学基金项目

负责人职称：副教授

依托单位：中国科学技术大学

资助金额： 24万元

关键词：药物传输系统;环境响应性高分子;高分子胶束;非病毒基因载体

起止时间： 2013-01-01到2015-12-31

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序号	标题	类型	作者
1	Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance	期刊论文	Ge, Zhishen\|Liu, Shiyong\|
2	Polyplex Micelles with Thermoresponsive Heterogeneous Coronas for Prolonged Blood Retention and Promoted Gene Transfection	期刊论文	Qixian Chen\|Guoying Zhang\|Shiyong Liu\|Zhishen Ge\|
3	Polyplex Micelles with Thermoresponsive Heterogeneous Coronas for Prolonged Blood Retention and Promoted Gene Transfection	期刊论文	Chen, Qixian\|Zhang, Guoying\|Liu, Shiyong\|Ge, Zhishen\|
4	PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers	期刊论文	Junjie Li, Zhishn Ge,* Shiyong Liu*\|
5	A Near-Infrared Photothermal Effect-Responsive Drug Delivery System Based on Indocyanine Green and Doxorubicin-Loaded Polymeric Micelles Mediated by Reversible Diels-Alder Reaction	期刊论文	Li, Hui\|Li, Junjie\|Ke, Wendong\|Ge, Zhishen\|
6	新型环境响应性嵌段聚合物基因载体的设计合成	会议论文
7	Redox-responsive core cross-linked micelles based on cypate and cisplatin prodrugs-conjugated block copolymers for synergistic photothermal-chemotherapy of cancer	期刊论文	Zan, Minghui\|Luo, Shizhong\|Ge, Zhishen\|Liu, Shiyong\|
8	PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers	期刊论文	Li, Junjie\|Ge, Zhishen\|Liu, Shiyong\|
9	Endogenous Stimuli-Sensitive Multistage Polymeric Micelleplex Anticancer Drug Delivery System for Ef？cient Tumor Penetration and Cellular Internalization	期刊论文	Hui Li\|Zengshi Zha\|Yu Han\|Zhishen Ge\|
10	Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin	期刊论文	Junjie Li,\|Zhishen Ge\|Shiyong Liu\|
11	Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer	期刊论文	Lin, Shanqing\|Luo, Dan\|Luo, Shizhong\|Ge, Zhishen\|
12	Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas	期刊论文	Gupte, Melanie J.\|Liu, Hao\|Song, Yueming\|Ge, Zhishen\|
13	Endosomal-Escape Polymers Based on Multicomponent Reaction-Synthesized Monomers Integrating Alkyl and Imidazolyl Moieties for Efficient Gene Delivery	期刊论文	Zha, Zengshi\|Li, Junjie\|Ge, Zhishen\|
14	Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin	期刊论文	Rehman, Saif Ur\|Siddiq, Mohammad\|Ge, Zhishen\|Liu, Shiyong\|
15	Dual pH-triggered multistage drug delivery systems based on host-guest interaction-associated polymeric nanogels	期刊论文	Zan, Minghui\|Li, Junjie\|Luo, Shizhong\|Ge, Zhishen\|
16	Tumor-Targeted Redox-Responsive Nonviral Gene Delivery Nanocarriers Based on Neutral-Cationic Brush Block Copolymers	期刊论文	Liu, Tao\|Zhang, Guoying\|Ge, Zhishen\|Liu, Shiyong\|
17	Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery	期刊论文	Matsumoto, Yu\|Osada, Kensuke\|Kataoka, Kazunori\|Ge, Zhishen\|
18	Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance	期刊论文	Zhishen Ge,* Shiyong Liu*\|
19	Facile Fabrication of Multistimuli-Responsive Metallo-Supramolecular Core Cross-Linked Block Copolymer Micelles	期刊论文	Ge, Zhishen\|Liu, Shiyong\|
20	基于肿瘤微环境响应性嵌段聚合物构筑新型聚合物纳米载体	会议论文

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