基于DNA编码蛋白表位模拟物库的靶向蛋白相互作用研究

21907011
2019
B0706.药物化学生物学
李亦舟
青年科学基金项目
教授
重庆大学
26万元
蛋白相互作用;高通量筛选;分子库;大环化合物;分子探针
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Selection of DNA-Encoded Chemical Libraries against Endogenous Membrane Proteins on Live Cells 期刊论文 Huang Yiran;Meng Ling;Nie Qigui;Zhou Yu;Chen Langdong;Yang Shilian;Fung Yi Man Eva;Li Xiaomeng;Huang Cen;Cao Yan;Li Yizhou;Li Xiaoyu
2 Strategies for developing DNA-encoded libraries beyond binding assays 期刊论文 Huang Yiran;Li Yizhou;Li Xiaoyu
3 DNA-Compatible ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications 期刊论文 Nie Qigui;Fang Xianfu;Liu Changyang;Zhang Gong;Fan Xiaohong;Li Yangfeng;Li Yizhou
4 Vinyl azide as a synthon for DNA-compatible divergent transformations into N-heterocycles 期刊论文 Sun Jie;Nie Qigui;Fang Xianfu;He Zhiwei;Zhang Gong;Li Yangfeng;Li Yizhou
5 Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical library 期刊论文 Gao Yuting;Sun Yang;Fang Xianfu;Zhao Guixian;Li Xufeng;Zhang Gong;Li Yangfeng;Li Yizhou
6 DNA-Compatible Synthesis of α, β-Epoxyketones for DNA-Encoded Chemical Libraries 期刊论文 Gao Yuting;Zhao Guixian;He Pengyang;Zhang Gong;Li Yangfeng;Li Yizhou
7 Second-generation DNA-encoded multiple display on a constant macrocyclic scaffold enabled by an orthogonal protecting group strategy 期刊论文 Nie Qigui;Zhong Shuting;Li Yangfeng;Zhang Gong;Li Yizhou
8 质谱技术在G-四链体研究中的进展 期刊论文 谭江;李亦舟;周江
9 Exploration of the formation and structure characteristics of a miR-92a promoter G-quadruplex by ESI-MS and CD 期刊论文 Xi Min;Li Yizhou;Zhou Jiang
10 DNA-Compatible Diversification of Indole π-Activated Alcohols via a Direct Dehydrative Coupling Strategy 期刊论文 Zhong Shuting;Fang Xianfu;Wang Yiting;Zhang Gong;Li Yangfeng;Li Yizhou
11 Switchable DNA-encoded Chemical Library: Interconversion between Double- and Single-Stranded DNA Formats 期刊论文 Zhao Guixian;Fan Xiaohong;Li Yangfeng;Zhang Gong;Li Yizhou
12 Converting double-stranded DNA-encoded libraries (DELs) to single-stranded libraries for more versatile selections 期刊论文 Gui Yuhan;Wong Clara Shania;Zhao Guixian;Xie Chao;Hou Rui;Li Yizhou;Li Gang;Li Xiaoyu
13 On-DNA Synthesis of Functionalized 4H‑Pyran Scaffolds for Focused DNA-Encoded Chemical Libraries 期刊论文 Gao Yuting;Sun Yang;Zhao Guixian;Zhang Gong;Li Yangfeng;Li Yizhou
14 Reversible Covalent Headpiece Enables Interconversion between Double- and Single-stranded DNA-encoded Chemical Libraries 期刊论文 Zhao Guixian;Zhong Shuting;Zhang Gong;Li Yangfeng;Li Yizhou
15 Strategies for targeting undruggable targets 期刊论文 Zhang Gong;Zhang Juan;Gao Yuting;Li Yangfeng;Li Yizhou
16 一种基于On-DNA芳基重氮盐中间体制备C-C偶联产物的方法 专利 李亦舟;李先锋;李杨峰;张娟
17 Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries 期刊论文 Fang Xianfu;Wang Yiting;He Pengyang;Liao Huilin;Zhang Gong;Li Yangfeng;Li Yizhou
18 Aryl Diazonium Intermediates Enable Mild DNA-Compatible C-C Bond Formation for Medicinally Relevant Combinatorial Library Synthesis 期刊论文 Li Xianfeng;Zhang Juan;Liu Changyang;Sun Jie;Li Yangfeng;Zhang Gong;Li Yizhou
19 In-Solution Direct Oxidative Coupling for the Integration of Sulfur /Selenium into DNA-Encoded Chemical Libraries 期刊论文 Yang Shilian;Zhao Guixian;Gao Yuting;Sun Yang;Fan Xiaohong;Zhang Gong;Li Yangfeng;Li Yizhou
20 Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries 期刊论文 Zhang Juan;Li Xianfeng;Wei Haimei;Li Yangfeng;Zhang Gong;Li Yizhou
21 一种DNA单双链可控转化的DNA编码化合物库合成方法 专利 李亦舟;赵桂贤;钟书婷
查看更多信息请先登录或注册

相关项目

趋势报告

经验分享