基于α-突触核蛋白朊蛋白样传播的帕金森病发病新机制的研究

81430025
2014
H0912.神经退行性变及相关疾病
李家驿
重点项目
教授
东北大学
320万元
朊蛋白样传播;α-突触核蛋白;帕金森病;蛋白质聚集;蛋白质错误折叠
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease 期刊论文 Chumarina Margarita;Azevedo Carla;Bigarreau Julie;Vignon Clementine;Kim Kwang Soo;Li Jia Yi;Roybon Laurent
2 Microbiome changes: an indicator of Parkinson's disease? 期刊论文 Haikal C;Chen Q. Q;Li J. Y.
3 Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson's Disease and Related Diseases 期刊论文 Sun Y;Guo C;Yuan L;Li W;Wang Z. Y;Yue F;Li J. Y.
4 Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy 期刊论文 Wu Jia Zhen;Ardah Mustafa;Haikal Caroline;Svanbergsson Alexander;Diepenbroek Meike;Vaikath Nishant N;Li Wen;Wang Zhan You;Outeiro Tiago F;El Agnaf Omar M;Li Jia Yi
5 Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies 期刊论文 Szego Eva M;Dominguez Meijide Antonio;Gerhardt Ellen;Koenig Annekatrin;Koss David J;Li Wen;Pinho Raquel;Fahlbusch Christiane;Johnson Mary;Santos Patricia;Villar Pique Anna;Thom Tobias;Rizzoli Silvio;Schmitz Matthias;Li Jiayi;Zerr Inga;Attems Johannes;Jahn Olaf;Outeiro Tiago F
6 Gut Inflammation in Association With Pathogenesis of Parkinson's Disease 期刊论文 Chen Qian Qian;Haikal Caroline;Li Wen;Li Jia Yi
7 Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges 期刊论文 Yuan Lin;Li Jia Yi
8 Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling 期刊论文 Wen Li;Shengdi Chen;Jia Yi Li
9 Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice 期刊论文 Xu Shuang Feng;Zhang Yan Hui;Wang Shan;Pang Zhong Qiu;Fan Yong Gang;Li Jia Yi;Wang Zhan You;Guo Chuang
10 Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease 期刊论文 Zhong Chong Bin;Chen Qian Qian;Haikal Caroline;Li Wen;Svanbergsson Alexander;Diepenbroek Meike;Li Jia Yi
11 Deferoxamine-mediated up-regulation of HIF-1 alpha. prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice 期刊论文 Guo Chuang;Hao Li-Juan;Yang Zhao-Hui;Chai Rui;Zhang Shuai;Gu Yu;Gao Hui-Ling;Zhong Man-Li;Wang Tao;Li Jia-Yi;Wang Zhan-You
12 Autonomic ganglionic injection of alpha-synuclein fibrils as a model of pure autonomic failure alpha-synucleinopathy 期刊论文 Wang X. J;Ma M. M;Zhou L. B;Jiang X. Y;Hao M. M;Teng R. K. F;Wu E;Tang B. S;Li J. Y;Teng J. F;Ding X. B.
13 Fungal acetylome comparative analysis identifies an essential role of acetylation in human fungal pathogen virulence. 期刊论文 Li Yanjian;Li Hailong;Sui Mingfei;Li Minghui;Wang Jiamei;Meng Yang;Sun Tianshu;Liang Qiaojing;Suo Chenhao;Gao Xindi;Li Chao;Li Zhuoran;Du Wei;Zhang Baihua;Sai Sixiang;Zhang Zhang;Ye Jing;Wang Hongchen;Yue Shang;Li Jiayi;Zhong Manli;Chen Changbin;Qi Shouliang;Lu Ling;Li Dancheng;Ding Chen
14 Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats 期刊论文 Holmqvist S;Chutna O;Boussel L;Aldrin-Kirk P;Li W;Björklund T;Wang ZY;Roybon L;Meiki R;Jia Yi Li
15 Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson's disease 期刊论文 Chen Qian Qian;Haikal Caroline;Li Wen;Li Ming Tao;Wang Zhan You;Li Jia Yi
16 2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson’s disease 期刊论文 Rafael Camacho;Daniela Täuber;Christian Hansen;Juanzi Shi;Luc Bousset;Ronald Melki;Jia Yi Li;Ivan G Scheblykin
17 Intranasal Lactoferrin Enhances alpha-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1 alpha Pathways in an Alzheimer's Disease Mouse Model 期刊论文 Guo Chuang;Yang Zhao-Hui;Zhang Shuai;Chai Rui;Xue Han;Zhang Yan-Hui;Li Jia-Yi;Wang Zhan-You
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