脑老化中苏木化异常修饰参与AD神经原纤维退变的分子机制研究

92049107
2020
H0902.意识障碍与认知功能障碍
王小川
重大研究计划
教授
华中科技大学
60万元
神经退变;阿尔茨海默病;β-淀粉样蛋白;Tau蛋白;苏木化
2021-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Ferulic Acid Improves Synaptic Plasticity and Cognitive Impairments by Alleviating the PP2B/DARPP-32/PP1 Axis-Mediated STEP Increase and Aβ Burden in Alzheimer's Disease. 期刊论文 Mahaman YAR;Huang F;Salissou MTM;Yacouba MBM;Wang JZ;Liu R;Zhang B;Li H;Zhu F;Wang XC
2 HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia 期刊论文 Ling Lei;Jun Feng;Gang Wu;Zhen Wei;Jian-Zhi Wang;Bin Zhang;Rong Liu;Fei Liu;Xiaochuan Wang;Hong-Lian Li
3 The Therapeutic Effects of Seven Lycopodium Compounds on Cell Models of Alzheimer’s Disease 期刊论文 Qian Guo;Qinfeng Cai;Fang Huang;Zhen Wei;Jianzhi Wang;Bin Zhang;Rong Liu;Yang Yang;Xiaochuan Wang;Li Hong-Lian
4 Inactivation of ERK1/2-CREB Pathway Is Implicated in MK801-induced Cognitive Impairment 期刊论文 Guo CP;Li W;Liu Y;Mahaman YAR;Zhang B;Wang JZ;Liu R;Li H;Wang XC;Gao X
5 USP10 deubiquitinates Tau, mediating its aggregation 期刊论文 Wei Z;Zeng K;Hu J;Li X;Huang F;Zhang B;Wang JZ;Liu R;Li HL;Wang XC
6 Novel small molecular compound 2JY-OBZ4 alleviates AD pathology in cell models via regulating multiple targets 期刊论文 Qian Guo;Gang Wu;Fang Huang;Zhen Wei;Jian-Zhi Wang;Bin Zhang;Rong Liu;Yang Yang;Xiaochuan Wang;Hong-Lian Li
7 Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration 期刊论文 Longfei Li;Yanli Jiang;Gang Wu;Yacoubou Abdoul Razak Mahaman;Dan Ke;Qun Wang;Bin Zhang;Jian-Zhi Wang;Hong-Lian Li;Rong Liu;Xiaochuan Wang
8 Tau Ubiquitination in Alzheimer's Disease. 期刊论文 Li L;Jiang Y;Wang JZ;Liu R;Wang XC
9 Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease. 期刊论文 Jia YR;Guo ZQ;Guo Q;Wang XC
10 Defective mitophagy and the etiopathogenesis of Alzheimer's disease 期刊论文 Zeng K;Yu X;Mahaman YAR;Wang JZ;Liu R;Li Y;Wang XC
11 The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders 期刊论文 Yacoubou Abdoul Razak Mahaman;Fang Huang;Kidane Siele Embaye;Xiaochuan Wang;Feiqi Zhu
12 C9orf72 poly‐PR helps p53 escape from the ubiquitin‐proteasome system and promotes its stability 期刊论文 Fumin Yang;Yacoubou Abdoul Razak Mahaman;Bin Zhang;Jian‐Zhi Wang;Rong Liu;Fei Liu;Xiaochuan Wang
13 c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6 期刊论文 Yanli Jiang;Longfei Li;Ruozhen Wu;Liulin Wu;Bin Zhang;Jian-Zhi Wang;Rong Liu;Fei Liu;Jing Wang;Xiaochuan Wang
14 Targeting the Transnitrosylation Cascade Provides a Novel Therapeutic Strategy for Alzheimer's Disease 期刊论文 Liu Y;Wu G;Shu XJ;Wang XC
15 Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice 期刊论文 Yacoubou Abdoul Razak Mahaman;Jun Feng;Fang Huang;Maibouge Tanko Mahamane Salissou;Jianzhi Wang;Rong Liu;Bin Zhang;Honglian Li;Feiqi Zhu;Xiaochuan Wang
16 Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention 期刊论文 Yacoubou Abdoul Razak Mahaman;Kidane Siele Embaye;Fang Huang;Longfei Li;Feiqi Zhu;Jian-Zhi Wang;Rong Liu;Jun Feng;Xiaochuan Wang
17 10..Zeng K, Yu X, Wei Z, Wu Y, Wang J, Liu R, Li Y, Wang XC. Single-nucleus transcriptome profiling of prefrontal cortex induced by chronic methamphetamine treatment. General Psychiatry 2023;36:e101057. doi:10.1136/gpsych-2023-101057 期刊论文 Zeng K;Yu X;Wei Z;Wu Y;Wang J;Liu R;Li Y;Wang XC
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