内侧隔核-海马胆碱能环路损伤在阿尔茨海默病空间记忆障碍中的作用及机制
91632305
2016
H0912.神经退行性变及相关疾病
王建枝
重大研究计划
教授
华中科技大学
240万元
tau蛋白;海马;阿尔茨海默病;神经环路;内侧隔核
2017-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation | 期刊论文 | Wei Yu Ping;Ye Jin Wang;Wang Xiong;Zhu Li Ping;Hu Qing Hua;Wang Qun;Ke Dan;Tian Qing;Wang Jian Zhi |
| 2 | Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms | 期刊论文 | Yang Ying;Wang Jian Zhi |
| 3 | Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3 | 期刊论文 | Lin Li;Cao Jie;Yang Shu Sheng;Fu Zheng Qi;Zeng Peng;Chu Jiang;Ning Lin Na;Zhang Teng;Shi Yan;Tian Qing;Zhou Xin Wen;Wang Jian Zhi |
| 4 | Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation | 期刊论文 | Ye J;Yin Y;Liu H;Fang L;Tao X;Wei L;Zuo Y;Yin Y;Ke D;Wang JZ |
| 5 | MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration | 期刊论文 | Feng Qiong;Luo Yu;Zhang Xiang Nan;Yang Xi Fei;Hong Xiao Yue;Sun Dong Shen;Li Xia Chun;Hu Yu;Li Xiao Guang;Zhang Jun Fei;Li Xiao;Yang Ying;Wang Qun;Liu Gong Ping;Wang Jian Zhi |
| 6 | Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect.Nature Communications | 期刊论文 | Guilin Pi;Di Gao;Dongqin Wu;Yali Wang;Huiyang Lei;Wenbo Zeng;Yang Gao;Huiling Yu;Rui Xiong;Tao Jiang;Shihong Li;Xin Wang;Jing Guo;Si Zhang;Taoyuan Yin;Ting He;Dan Ke;Ruining Li;Honglian Li;Gongping Liu;Xifei Yang;Min–Hua Luo;Xiaohui Zhang;Ying Yang;Jian–Zhi Wang |
| 7 | Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression | 期刊论文 | Li Xiao Guang;Hong Xiao Yue;Wang Ya li;Zhang Shu Juan;Zhang Jun Fei;Li Xia Chun;Liu Yan Chao;Sun Dong Shen;Feng Qiong;Ye Jin Wang;Gao Yuan;Ke Dan;Wang Qun;Li Hong lian;Ye Keqiang;Liu Gong Ping;Wang Jian Zhi |
| 8 | Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia | 期刊论文 | Guo Jing;Xu Cheng;Ni Shaozhou;Zhang Shujuan;Li Qihang;Zeng Peng;Pi Guilin;Liu Enjie;Sun Dong Sheng;Liu Yanchao;Wang Zhouyi;Chen Haote;Yang Ying;Wang Jian Zhi |
| 9 | Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting | 期刊论文 | Zhang Yao;Xie Jia Zhao;Xu Xiang Yang;Hu Jun;Xu Teng;Jin Si;Yang Shao Juan;Wang Jian Zhi |
| 10 | TRPC1 Null Exacerbates Memory Deficit and Apoptosis Induced by Amyloid-beta | 期刊论文 | Li Mengzhu;Liu Enjie;Zhou Qiuzhi;Li Shihong;Wang Xin;Liu Yanchao;Wang Lin;Sun Dongsheng;Ye Jinwang;Gao Yuan;Yang Xifei;Liu Jianjun;Yang Ying;Wang Jian Zhi |
| 11 | GSK-3 beta deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory | 期刊论文 | Liu Enjie;Xie Ao Ji;Zhou Qiuzhi;Li Mengzhu;Zhang Shujuan;Li Shihong;Wang Weijin;Wang Xiaochuan;Wang Qun;Wang Jian Zhi |
| 12 | Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity | 期刊论文 | Yuan Gao;En Jie Liu;Wei Jin Wang;Ya Li Wang;Xiao Guang Li;Xin Wang;Shi Hong Li;Shu Juan Zhang;Meng Zhu Li;Qiu Zhi Zhou;Xiao Bing Long;Hua Qiu Zhang;Jian Zhi Wang |
| 13 | Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer's disease | 期刊论文 | Liu Enjie;Zhou Qiuzhi;Xie Ao Ji;Li Mengzhu;Zhang Shujuan;Huang Hezhou;Liuyang Zhenyu;Wang Yali;Liu Bingjin;Li Xiaoguang;Sun Dongsheng;Wei Yuping;Wang Xiaochuan;Wang Qun;Ke Dan;Yang Xifei;Yang Ying;Wang Jian Zhi |
| 14 | Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina | 期刊论文 | Guo Jing;Ni Shaozhou;Li Qihang;Wang Jian Zhi;Yang Ying |
| 15 | 促进tau蛋白去磷酸化的嵌合体及其编码基因以及它们的应用 | 专利 | 王建枝;郑杰 |
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