DDX3X调控CD4+T淋巴细胞NLRP3/caspase-1信号通路促进脓毒症PICS的作用及机制研究
82002101
2020
H1602.器官功能衰竭与支持
王于昌
青年科学基金项目
主治医师
华中科技大学
24万元
脓毒症;持续性炎症-免疫抑制-分解代谢综合征;焦亡;DDX3X;T淋巴细胞
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | DDX3X mRNA Expression in T Cells Is Associated with the Severity and Mortality of Septic Patients. | 期刊论文 | Liu Yukun;Zhang Yongsheng;Liu Qinxin;Xie Weiming;Wang Xiang;Yang Fan;Gao Wei;Bai Xiangjun;Li Zhanfei;Wang Yuchang |
| 2 | GPA Peptide Attenuates Sepsis-Induced Acute Lung Injury in Mice via Inhibiting Oxidative Stress and Pyroptosis of Alveolar Macrophage. | 期刊论文 | Liu Yukun;Zhang Yongsheng;Feng Quanrui;Liu Qinxin;Xie Jie;Li Hui;Yang Fan;Liu Xinghua;Gao Wei;Bai Xiangjun;Li Zhanfei;Wang Yuchang |
| 3 | Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3 | 期刊论文 | Chuntao Wang;Yukun Liu;Yongsheng Zhang;Dongfang Wang;Ligang Xu;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 4 | Alpinetin Attenuates Persistent Inflammation, Immune Suppression, and Catabolism Syndrome in a Septic Mouse Model | 期刊论文 | Yukun Liu;Kang Wang;Qaunrui Feng;Yongsheng Zhang;Chuntao Wang;Qinxin Liu;Xinghua Liu;Xiang Wang;Wei Gao;Xiangjun Bai;Zhanfei Li;Yuchang Wang |
| 5 | Development and validation of a nomogram for predicting persistent inflammation, immunosuppression, and catabolism syndrome in trauma patients | 期刊论文 | Ligang Xu;Zhaofeng Kang;Dongfang Wang;Yukun Liu;Chuntao Wang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 6 | Melatonin: A potential adjuvant therapy for septic myopathy | 期刊论文 | Yukun Liu;Dongfang Wang;Tianyu Li;Ligang Xu;Zhanfei Li;Xiangjun Bai;Manli Tang;Yuchang Wang |
| 7 | Inhibition of DDX3X ameliorated CD4 + T cells pyroptosis and improves survival in septic mice | 期刊论文 | Yukun Liu;Yongsheng Zhang;Qinxin Liu;Tianyu Li;Wei Wang;Hui Li;Fan Yang;Wei Gao;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 8 | The role of NLRP3 inflammasome in inflammation- related skeletal muscle atrophy | 期刊论文 | Yukun Liu;Dongfang Wang;Tianyu Li;Fan Yang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 9 | Inhibition of DDX3X alleviates persistent inflammation, immune suppression and catabolism syndrome in a septic mice model | 期刊论文 | Yukun Liu;Yongsheng Zhang;Chuntao Wang;Qinxin Liu;Tianyu Li;Wei Wang;Fan Yang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 10 | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota | 期刊论文 | Yukun Liu;Ligang Xu;Zhaohui Yang;Dongfang Wang;Tianyu Li;Fan Yang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 11 | Inhibition of PFKFB Preserves Intestinal Barrier Function in Sepsis by Inhibiting NLRP3/GSDMD | 期刊论文 | Yongsheng Zhang;Yukun Liu;Zhenxing Xie;Qinxin Liu;Yangfan Zhuang;Weiming Xie;Xiang Wang;Wei Gao;Fan Yang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
| 12 | Inhibition of the C3a receptor attenuates sepsis-induced acute lung injury by suppressing pyroptosis of the pulmonary vascular endothelial cells | 期刊论文 | Feng Quan-Rui;Zhuang Yang-Fan;Xie Zhen-Xing;Li Zhan-fei;Wang Yu-Chang |
| 13 | Ibrutinib protects against acute lung injury via inhibiting NLRP3/Caspase-1 in septic mice model | 期刊论文 | Huiming Tang;Hui Li;Yang Yang;Manli Tang;Zhanfei Li;Xiangjun Bai;Yuchang Wang |
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