二氨基二酸替代二硫键类多肽药物的化学合成及结构-活性关系研究

21572214
2015
B0702.生物分子的化学生物学
石景
面上项目
副教授
中国科学技术大学
65万元
二硫键化学替代;多肽化学合成;多肽/蛋白质药物;二氨基二酸
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A diubiquitin-based photoaffinity probe for profiling K27-linkage targeting deubiquitinases 期刊论文 Tan Xiao Dan;Pan Man;Gao Shuai;Zheng Yong;Shi Jing;Li Yi Ming
2 Mechanism and Origin of the Stereoselectivity in the Palladium-Catalyzed trans Hydroboration of Internal 1,3-Enynes with an Azaborine-Based Phosphine Ligand 期刊论文 Yang Yinuo;Jiang Julong;Yu Haizhu;Shi Jing
3 An activity-based probe developed by a sequential dehydroalanine formation strategy targets HECT E3 ubiquitin ligases 期刊论文 Xu Ling;Fan Jian;Wang Yu;Zhang Zhongping;Fu Yao;Li Yi Ming;Shi Jing
4 Efficient semi-synthesis of ubiquitin-7-amino-4-methylcoumarin 期刊论文 Chu Guo Chao;Bai Jing Si;Kong Yi Fu;Fan Jian;Sun Shuai Shuai;Xu Hua Jian;Shi Jing;Li Yi Ming
5 辅基连接臂、其合成方法与二泛素的合成方法 专利 黄健丰;石景;储国超
6 Mechanism for the enhanced reactivity of 4-mercaptoprolyl thioesters in native chemical ligation 期刊论文 Shah Muhammad Ishaq Ali;Xu Zhe-Yuan;Liu Lei;Jiang Yuan-Ye;Shi Jing
7 Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes 期刊论文 Cheng Wan-Min;Lu Xi;Shi Jing;Liu Lei
8 Efficient chemical synthesis for the analogue of ubiquitin-based probe Ub-AMC with native bioactivity 期刊论文 Xu Ling;Xu Yang;Qu Qian;Guan Chao-Jian;Chu Guo-Chao;Shi Jing;Li Yi-Ming
9 Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy 期刊论文 Zuo Chao;Yan Bing-Jia;Zhu Han-Ying;Shi Wei-Wei;Xi Tong-Kuai;Shi Jing;Fang Ge-Min
10 Dmab/ivDde protected diaminodiacids for solid-phase synthesis of peptide disulfide-bond mimics 期刊论文 Xu Yang;Wang Tao;Guan Chao Jian;Li Yi Ming;Liu Lei;Shi Jing;Bierer Donald
11 Chemical Synthesis of Natural Polyubiquitin Chains through Auxiliary-Mediated Ligation of an Expressed Ubiquitin Isomer 期刊论文 Xu Ling;Huang Jian-Feng;Chen Chen-Chen;Qu Qian;Shi Jing;Pan Man;Li Yi-Ming
12 Efficient synthesis of hydrocarbon-bridged diaminodiacids through nickel-catalyzed reductive cross-coupling 期刊论文 Wang Tao;Kong Yi-Fu;Xu Yang;Fan Jian;Xu Hua-Jian;Bierer Donald;Wang Jun;Shi Jing;Li Yi-Ming
13 Synthesis of Peptide Disulfide-Bond Mimics by Using Fully Orthogonally Protected Diaminodiacids 期刊论文 Wang Tao;Fan Jian;Chen Xiao Xu;Zhao Rui;Xu Yang;Bierer Donald;Liu Lei;Li Yi Ming;Shi Jing;Fang Ge Min
14 Mechanistic Study of Copper-Catalyzed Decarboxylative C-N Cross-Coupling with Hypervalent Iodine Oxidant 期刊论文 Yang Yi-Nuo;Jiang Ju-Long;Shi Jing
15 Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin–ferroportin interaction 期刊论文 Huang Dong-Liang;Bai Jing-Si;Wu Meng;Wang Xia;Ried Bernd;Pook Elisabeth;Alt Carsten;Erny Marion;Li Yi-Ming;Bierer Donald;Shi Jing;Fang Ge-Min
16 Efficient Semi-Synthesis of Atypical Ubiquitin Chains and Ubiquitin-Based Probes Forged by Thioether Isopeptide Bonds 期刊论文 Chu Guo-Chao;Hua Xiao;Zuo Chong;Chen Chen-Chen;Meng Xian-Bin;Zhang Zhongping;Fu Yao;Shi Jing;Li Yi-Ming
17 Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents 期刊论文 Xu Yang;Wang Yu;Liu Peiyuan;Chu Guo-Chao;Xu Huajian;Li Yi-Ming;Wang Jun;Shi Jing
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