新型选择性CARM1抑制剂的设计、合成及生物活性研究

81803339
2018
H3401.合成药物化学
金甲
青年科学基金项目
副教授
浙江理工大学
21万元
抗肿瘤;CARM1;药物化学;蛋白质精氨酸甲基转移酶;表观遗传学
2019-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 PRMTI型甲基转移酶抑制活性化合物及其制备与应用 专利 叶飞;金甲;王磊
2 Berberine-Coated Biomimetic Composite Microspheres for Simultaneously Hemostatic and Antibacterial Performance 期刊论文 Zhang Xiaojian;Dai Kaili;Liu Chenyu;Hu Haofeng;Luo Fulin;Qi Qifan;Wang Lei;Ye Fei;Jin Jia;Tang Jie;Yang Fan
3 The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein- Protein Interaction 期刊论文 Xiaoqing Ye;Gang Chen;Jia Jin;Binzhong Zhang;Yinda Wang;Zhenhai Cai;Fei Ye
4 Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy. 期刊论文 Jin Jia;Xu Ming;Liu Yixuan;Ji Zhixiao;Dai Kaili;Zhang Lun;Wang Lei;Ye Fei;Chen Gang;Lv Zhengbing
5 Identification, Synthesis and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases (PRMTs) 期刊论文 Xiao Li;Lun Zhang;Jing Xu;Chenyu Liu;Xiaojian Zhang;Amr Abbas Abdelmoneim;Qian Zhang;Jiaqi Ke;Yingnan Zhang;Lei Wang;Fan Yang;Cheng Luo;Jia Jin;Fei Ye
6 Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B) 期刊论文 Jin Jia;Ye Xiaoqing;Boateng Derrick;Dai Kaili;Ye Fei;Du Pengfei;Yu Han
7 The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening 期刊论文 Ye Xiaoqing;Zhang Rukang;Lian Fulin;Zhang Weiyao;Lu Wenchao;Han Jie;Zhang Naixia;Jin Jia;Luo Cheng;Chen Kaixian;Ye Fei;Ding Hong
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