外泌体miR-122表达下调通过激活RhoA/ROCK1通路参与胃癌腹膜转移的分子调控机制及潜在临床应用研究
81872341
2018
H1809.肿瘤复发与转移
沈琳
面上项目
主任医师
北京大学
57万元
C07_胃肿瘤;miR-122;腹膜转移;外泌体;RhoA/ROCK1通路
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Identification of “regulation of RhoA activity panel” as a prognostic and predictive biomarker for gastric cancer | 期刊论文 | Wenwen Huang;Songhui Zhao;Cheng Zhang;Zhongwu Li;Sai Ge;Baofeng Lian;Hui Feng;Kai Wang;Ruihua Xu;Jiafu Ji;Jing Gao;Weiwei Shi;Lin Shen |
| 2 | Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer | 期刊论文 | Cheng Zhang;Xiaoyi Chong;Fangli Jiang;Jing Gao;Yang Chen;Keren Jia;Meng Fan;Xuan Liu;Jin An;Jian Li;Xiaotian Zhang;Lin Shen |
| 3 | 中华医学科技奖一等奖 | 奖励 | 沈琳;李健;高静;张小田;鲁智豪;李一林;章程;陆明;王晰程;彭智;周军;龚继芳;齐长松;葛赛;李艳艳 |
| 4 | Clinical implications of plasma ctDNA features and dynamics in gastric cancer treated with HER2-targeted therapies | 期刊论文 | Zhang Cheng;Chen Zuhua;Chong Xiaoyi;Chen Yang;Wang Zhenghang;Yu Ruoying;Sun Tingting;Chen Xiaoxi;Shao Yang;Zhang Xiaotian;Gao Jing;Shen Lin |
| 5 | 用于胃癌免疫治疗疗效预测的细胞外囊泡膜蛋白检测方法 | 专利 | 章程;沈琳;蒋枋利;樊萌;刘轩;安瑾 |
| 6 | 中国抗癌协会科技奖一等奖 | 奖励 | 沈琳;李健;高静;张小田;鲁智豪;李一林;章程;陆明;王晰程;彭智 |
| 7 | Extracellular Vesicle-Derived Protein File from Peripheral Blood Predicts Immune-Related Adverse Events in Gastric Cancer Patients Receiving Immunotherapy. | 期刊论文 | Fangli Jiang;Zhening Zhang;Xiaoyi Chong;Lin Shen;Meng Fan;Xuan Liu;Jin An;Zhi Peng;Cheng Zhang |
| 8 | Association of Lymphocyte-to-Monocyte Ratio With Survival in Advanced Gastric Cancer Patients Treated With Immune Checkpoint Inhibitor | 期刊论文 | Yang Chen;Cheng Zhang;Zhi Peng;Changsong Qi;Jifang Gong;Xiaotian Zhang;Jian Li;Lin Shen |
| 9 | miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer | 期刊论文 | Cheng Zhang;Jing Yang;Yang Chen;Fangli Jiang;Haiyan Liao;Xiang Liu;Yuan Wang;Guanyi Kong;Xiaotian Zhang;Jian Li;Jing Gao;Lin Shen |
| 10 | Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients | 期刊论文 | Yang Chen;Yanyan Li;Changsong Qi;Cheng Zhang;Dan Liu;Youping Deng;Yuanyuan Fu;Vedbar S. Khadka;Daisy Dandan Wang;Shanyang Tan;Shujun Liu;Zhi Peng;Jifang Gong;Peter Ping Lin;Xiaotian Zhang;Jian Li;Yilin Li;Lin Shen |
| 11 | Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer | 期刊论文 | Yanting Hu;Changsong Qi;Xiang Liu;Cheng Zhang;Jing Gao;Yi Wu;Jing Yang;Qian Zhao;Jian Li;Xiaojuan Wang;Lin Shen |
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