BRG1/miR-485-3p/PAK1轴调控胰腺癌细胞迁移、侵袭及干性维持的机制研究

81871954
2018
H1820.肿瘤综合治疗
杨尹默
面上项目
教授
北京大学
58万元
BRG1;胰腺肿瘤干细胞;PAK1;miR-485-3p;表观遗传调节
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target 期刊论文 Di Long;Kai Chen;Yinmo Yang;Xiaodong Tian
2 Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study 期刊论文 Xuehai Xie;Kai Chen;Zonghao Liu;Feng Wang;Yongsu Ma;Shupeng Zhang;Zhijiang Shao;Yinmo Yang;Xiaodong Tian
3 胰腺癌综合治疗一例 期刊论文 曲畅;马永蔌;王峰;陈依然;田孝东;杨尹默
4 Predictive Model of Early Death of Resectable Pancreatic Ductal Adenocarcinoma After Curative Resection: A SEER-Based Study 期刊论文 Weikang Liu;Yongsu Ma;Bingjun Tang;Chang Qu;Yiran Chen;Yinmo Yang;Xiaodong Tian
5 根治性顺行模块化胰脾切除术治疗胰体尾癌安全性与有效性的Meta分析 期刊论文 陈凯;王琦;高红桥;杨尹默;田孝东
6 The Role of Exosomes in Pancreatic Cancer From Bench to Clinical Application: An Updated Review 期刊论文 Kai Chen;Qi Wang;Marko Kornmann;Xiaodong Tian;Yinmo Yang
7 胰腺癌合并肝脏寡转移:联合切除还是姑息治疗 期刊论文 杨尹默;刘光年
8 Preoperative prediction of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy 期刊论文 Lin Ziying;Tang Bingjun;Cai Jinxiu;Wang Xiangpeng;Li Changxin;Tian Xiaodong;Yang Yinmo;Wang Xiaoying
9 BRM transcriptionally regulates miR-302a-3p to target SOCS5/STAT3 signaling axis to potentiate pancreatic cancer metastasis. 期刊论文 Zhang Z;Li J;Guo H;Wang F;Ma L;Du C;Wang Y;Wang Q;Kornmann M;Tian X;Yang Y
10 Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression 期刊论文 Kai Chen;Qi Wang;Mingzhe Li;Huahu Guo;Weikang Liu;Feng Wang;Xiaodong Tian;Yinmo Yang
11 铁死亡机制在胰腺癌中的研究现状与进展 期刊论文 刘鑫鑫;田孝东;杨尹默
12 Validation and modification of the AJCC 8th TNM staging system for pancreatic ductal adenocarcinoma in a Chinese cohort: A nationwide pancreas data center analysis 期刊论文 Hu Hao;Qu Chang;Tang Bingjun;Liu Weikang;Ma Yongsu;Chen Yiran;Xie Xuehai;Zhuang Yan;Gao Hongqiao;Tian Xiaodong;Yang Yinmo
13 分子靶向时代胰腺癌综合诊治的现状与展望 期刊论文 张正奎;杨尹默
14 Predicting early recurrence for resected pancreatic ductal adenocarcinoma: a multicenter retrospective study in China. 期刊论文 Weikang Liu;Bingjun Tang;Feng Wang;Chang Qu;Hao Hu;Yan Zhuang;Hongqiao Gao;Xuehai Xie;Xiaodong Tian;Yinmo Yang
15 Crosstalk between Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in the Tumor Microenvironment Mediated by Exosomal MicroRNAs 期刊论文 Xiangyu Chu;Yinmo Yang;Xiaodong Tian
16 Stroma-targeted nanoparticles that remodel stromal alignment to enhance drug delivery and improve the antitumor efficacy of Nab-paclitaxel in pancreatic ductal adenocarcinoma models 期刊论文 Dan Wei;Xiaoyu Cheng;Chong Du;Yazhou Wang;Jingyi Sun;Chen Li;Jing Wu;Xiaodong Tian;Ying Zhao;Guangjun Nie;Yinmo Yang
17 胰腺黏液性囊性肿瘤38例临床诊治分析 期刊论文 曹曦;田孝东;马永蔌;谢学海;高红桥;庄岩;郭小超;张继新;杨尹默
18 CPDC及SEER数据库中胰腺癌术后患者预后因素的比较研究 期刊论文 胡浩;曲畅;田孝东;杨尹默
19 LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway 期刊论文 Feng Wang;Long Rong;Zhengkui Zhang;Mingzhe Li;Ling Ma;Yongsu Ma;Xuehai Xie;Xiaodong Tian;Yinmo Yang
20 缝合还是器械闭合:胰体尾切除术胰腺残端处理 期刊论文 曲畅;杨尹默
21 A modified alternative fistula risk score (a-FRS) obtained from the computed tomography enhancement pattern of the pancreatic parenchyma predicts pancreatic fistula after pancreatoduodenectomy 期刊论文 Bingjun Tang;Zhimiao Lin;Yongsu Ma;Aoran Zhang;Weikang Liu;Jixin Zhang;Xiaoying Wang;Xiaodong Tian;Yinmo Yang
22 Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma: potential diagnostic and prognostic significance in clinical practice. 期刊论文 Xudong Zhao;Yongsu Ma;Xiu Dong;Zhengkui Zhang;Xiaodong Tian;Xiaohang Zhao;Yinmo Yang
23 Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1 期刊论文 Mingzhe Li;Jiaxin Zhou;Zhengkui Zhang;Jisong Li;Feng Wang;Ling Ma;Xiaodong Tian;Zebin Mao;Yinmo Yang
24 Trap and kill strategy for non-BRCA mutant pancreatic cancer by co-delivery of olaparib and JQ1 with plectin-1 targeting peptide nanoparticles. 期刊论文 Wang Y;Du C;Zhao Y;Nie G;Yang Y
25 日本胰腺协会《胰腺癌临床实践指南(2019)》更新解读 期刊论文 刘光年;许静涌;杨尹默
26 加速康复外科理念在胰腺外科中的应用与思考 期刊论文 田孝东;杨尹默
27 伴破骨样巨细胞胰腺未分化癌的临床病理特征与治疗策略 期刊论文 马永蔌;赵旭东;张继新;柳萍;郭小超;田孝东;杨尹默
28 Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis 期刊论文 Xinxin Liu;Kai Chen;Xiangyu Chu;Guangnian Liu;Yinmo Yang;Xiaodong Tian
29 Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression 期刊论文 Kai Chen;Qi Wang;Xinxin Liu;Feng Wang;Yinmo Yang;Xiaodong Tian
30 Development and Validation of Prognostic and Diagnostic Model for Pancreatic Ductal Adenocarcinoma Based on scRNA-Seq and Bulk-Seq Datasets 期刊论文 Kai Chen;Xinxin Liu;Di Long;Weikang Liu;Feng Wang;Yinmo Yang;Xiaodong Tian
31 The management strategy of pancreatic cancer in the era of systemic therapy—“Surgery First” or “Surgery Last”? 期刊论文 Yinmo Yang;Xiaodong Tian
32 Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway. 期刊论文 Li M;Guo H;Wang Q;Chen K;Kornmann M;Tian X;Yang
33 Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma 期刊论文 Kai Chen;Qi Wang;Xinxin Liu;Feng Wang;Yongsu Ma;Shupeng Zhang;Zhijiang Shao;Yinmo Yang;Xiaodong Tian
34 Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/PI3K/AKT axis 期刊论文 Wang Yazhou;Guo Huahu;Zhang Zhengkui;Wang Qi;Tian Xiaodong;Yang Yinmo
35 合成致死效应在胰腺癌精准治疗中的应用及研究进展 期刊论文 陈凯;田孝东;杨尹默
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