基于抗生素生物合成元件挖掘策略的新抗菌化合物的发现及活性评价
31872614
2018
C0101.微生物多样性、分类与系统发育
高书山
面上项目
研究员
中国科学院微生物研究所
61万元
次级代谢产物;异源表达;抗菌活性;基因组挖掘;生物合成基因簇
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Overproduction of medicinal ergot alkaloids based on a fungal platform | 期刊论文 | Yongpeng Yao;Wei Wang;Wenyu Shi;Rui Yan;Jun Zhang;Guangzheng Wei;Ling Liu;Yongsheng Che;Chunyan An;Shu-Shan Gao |
| 2 | De novo biosynthesis and gram-level production of m-cresol in Aspergillus nidulans | 期刊论文 | Wang Wei;An Chunyan;Yao Yongpeng;Meng Xiangxi;Gao Shu-Shan |
| 3 | A Dual-Plasmid CRISPR/Cas System for Mycotoxin Elimination in Polykaryotic Industrial Fungi | 期刊论文 | Weiwei Liu;Chunyan An;Xian Shu;Xiangxi Meng;Yongpeng Yao;Jun Zhang;Fusheng Chen;Hua Xiang;Shuyuan Yang;Xue Gao;Shu-Shan Gao |
| 4 | Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids | 期刊论文 | Yao Yongpeng;An Chunyan;Evans Declan;Liu Weiwei;Wang Wei;Wei Guangzheng;Ding Ning;Houk K N;Gao Shu Shan |
| 5 | Actinomycetes-derived imine reductases with a preference towards bulky amine substrates | 期刊论文 | Jun Zhang;Xin Li;Rongchang Chen;Xianwei Tan;Xiongduo Liu;Yaqing Ma;Fangfang Zhu;Chunyan An;Guangzheng Wei;Yongpeng Yao;Lujia Yang;Peng Zhang;Qiaqing Wu;Zhoutong Sun;Bin-Gui Wang;Shu-Shan Gao;Chengsen Cui |
| 6 | A combined strategy for the overproduction of complex ergot alkaloid agroclavine. | 期刊论文 | Zhipu Yu;Chunyan An;Yongpeng Yao;Chang-Yun Wang;Zhoutong Sun;Chengsen Cui;Ling Liu;Shu-Shan Gao |
| 7 | TerC Is a Multifunctional and Promiscuous Flavoprotein Monooxygenase That Catalyzes Bimodal Oxidative Transformations | 期刊论文 | Xian Shu;Guangzheng Wei;Yuben Qiao;Kexin Zhang;Jun Zhang;Guomin Ai;Man-Cheng Tang;Yonghui Zhang;Shu-Shan Gao |
| 8 | A hybrid system for the overproduction of complex ergot alkaloid chanoclavine | 期刊论文 | Yaqing Ma;Juzhang Yan;Lujia Yang;Yongpeng Yao;Luoyi Wang;Shu-Shan Gao;Chengsen Cui |
| 9 | Heterologous Production of Unnatural Flavipucine Family Products Provides Insights into Flavipucines Biosynthesis. | 期刊论文 | Xian Shu;Guangzheng Wei;Jun Zhang;Kexin Zhang;Yongpeng Yao;Shu-Shan Gao |
| 10 | Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids | 期刊论文 | Chunyan An;Fangfang Zhu;Yongpeng Yao;Kexin Zhang;Wei Wang;Jun Zhang;Guangzheng Wei;Yue Xia;Qiang Gao;Shu-Shan Gao |
查看更多信息请先登录或注册
