胰高糖素受体单抗对胰岛α细胞增生及向β细胞转化的作用及机制研究

81770768
2017
H0706.胰岛生理调控与功能异常
魏蕊
面上项目
研究员
北京大学
56万元
细胞转分化;胰高糖素受体;胰岛α细胞;胰岛再生;胰岛功能调控
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Glucagon receptor antagonism increases mouse pancreatic δ-cell mass through cell proliferation and duct-derived neogenesis 期刊论文 Gu Liangbiao;Cui Xiaona;Lang Shan;Wang Haining;Hong Tianpei;Wei Rui
2 Pancreatic β cell regeneration induced by clinical and preclinical agents 期刊论文 Wang Kang-Li;Tao Ming;Wei Tian-Jiao;Wei Rui
3 Combination of GLP-1 receptor activation and glucagon blockage promotes pancreatic β-cell regeneration in situ in type 1 diabetic mice 期刊论文 Gu Liangbiao;Wang Dandan;Cui Xiaona;Wei Tianjiao;Yang Kun;Yang Jin;Wei Rui;Hong Tianpei
4 FoxO1 inhibition promotes differentiation of human embryonic stem cells into insulin producing cells 期刊论文 Yu Fei;Wei Rui;Yang Jin;Liu Junling;Yang Kun;Wang Haining;Mu Yiming;Hong Tianpei
5 利拉鲁肽对小鼠胰岛β细胞产生FGF-21的影响及其潜在机制 期刊论文 葛李娜;魏蕊;杨琨;杨进;洪天配
6 胰升糖素受体单克隆抗体:糖尿病药物治疗的新方向 期刊论文 郎杉;魏蕊;洪天配
7 胰岛 β 细胞异质性的相关研究进展 期刊论文 谷良标;魏蕊;洪天配
8 Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes 期刊论文 Lang Shan;Yang Jin;Yang Kun;Gu Liangbiao;Cui Xiaona;Wei Tianjiao;Liu Junling;Le Yunyi;Wang Haining;Wei Rui;Hong Tianpei
9 Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice 期刊论文 Wei Rui;Cui Xiaona;Feng Jin;Gu Liangbiao;Lang Shan;Wei Tianjiao;Yang Jin;Liu Junling;Le Yunyi;Wang Haining;Yang Kun;Hong Tianpei
10 Anti-proliferative effect of rosiglitazone in the human T-lymphocyte leukaemia cell line Jurkat cells 期刊论文 Wei Rui;Yu Fei;Yang Jin;Gao Hongwei;Wang Haining;Hong Tianpei
11 胰岛α细胞功能和表型变化在糖尿病治疗学中的重要意义 期刊论文 魏蕊;洪天配
12 抑制叉头转录因子O1表达可促进人胚胎干细胞向胰岛素分泌细胞分化 期刊论文 于菲;魏蕊;杨进;洪天配
13 Liver-derived fibroblast growth factor 21 mediates effects 
of glucagon-like peptide-1 in attenuating hepatic glucose output 期刊论文 Liu Junling;Yang Kun;Yang Jin;Xiao Wenhua;Le Yunyi;Yu Fei;Gu Liangbiao;Lang Shan;Tian Qing;Jin Tianru;Wei Rui;Hong Tianpei
14 Antagonistic glucagon receptor antibody promotes α-cell proliferation and increases β-cell mass in diabetic mice 期刊论文 Wei Rui;Gu Liangbiao;Yang Jin;Yang Kun;Liu Junling;Le Yunyi;Lang Shan;Wang Haining;Thai Dung;Yan Hai;Hong Tianpei
15 不同剂量链脲佐菌素对小鼠胰岛结构和主要细胞组成影响的研究 期刊论文 魏蕊;谷良标;杨进;葛李娜;洪天配
16 Liraglutide ameliorates palmitate-induced oxidative injury in islet microvascular endothelial cells through GLP-1 receptor/PKA and GTPCH1/eNOS signaling pathways 期刊论文 Le Yunyi;Wei Rui;Yang Kun;Lang Shan;Gu Liangbiao;Liu Junling;Hong Tianpei;Yang Jin
17 胰岛β细胞再生治疗:距离临床应用还远吗? 期刊论文 魏蕊;洪天配
18 SGLT2抑制剂对胰岛β细胞的保护作用及潜在机制 期刊论文 王康丽;洪天配;魏蕊
19 我国GLP-1受体激动剂治疗糖尿病的临床与基础研究 期刊论文 刘珺玲;魏蕊;洪天配
20 GLP-1 receptor agonists stimulate ANGPTL8 production through the PI3K/Akt pathway in a GLP-1 receptor-dependent manner 期刊论文 Liu Junling;Yang Kun;Xiao Wenhua;Le Yunyi;Lang Shan;Zhang Jingjing;Wei Rui;Yang Jin;Hong Tianpei
21 Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice 期刊论文 Lang Shan;Wei Rui;Wei Tianjiao;Gu Liangbiao;Feng Jin;Yan Hai;Yang Jin;Hong Tianpei
22 肠道胰高糖素原衍生肽在血糖稳态调控和糖尿病治疗中的作用 期刊论文 郎杉;洪天配;魏蕊
23 Synergistic anti-tumor effects of liraglutide with metformin on pancreatic cancer cells 期刊论文 Lu Ran;Yang Jin;Wei Rui;Ke Jing;Tian Qing;Yu Fei;Liu Junling;Zhang Jingjing;Hong Tianpei
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