热休克蛋白gp96作为新型疫苗佐剂在细胞免疫与体液免疫应答中的作用机制
31230026
2012
C0808.疫苗、抗体与免疫干预
孟颂东
重点项目
研究员
中国科学院微生物研究所
285万元
细胞免疫;疫苗佐剂;免疫激活剂;gp96;体液免疫
2013-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses | 期刊论文 | Zhao Bao; Wang Yanzhong; Zhang Yu; Li Yang; Zhang Xiaojun; Xu Yaxing; Chen Lizhao; Li Changfei; Ju Ying; Meng Songdong |
| 2 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes | 期刊论文 | Sun Lu;Zhang Yu;Zhao Bao;Deng Mengmeng;Liu Jun;Li Xin;Hou Junwei;Gui Mingming;Zhang Shuijun;Li Xiaodong;Gao George F.;Meng Songdong |
| 3 | Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5 | 期刊论文 | Li Xin;Wu Bo;Chen Lizhao;Ju Ying;Li Changfei;Meng Songdong |
| 4 | Heat-Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette-Guerin Vaccine | 期刊论文 | Ding Y.;Zheng H.;Feng C.;Wang B.;Liu C.;Mi K.;Cao H.;Meng S. |
| 5 | Prophylactic cancer vaccine, from concept to reality? | 期刊论文 | Zhao Bao;Li Xin;Wang Beinan;Gao Bin;Meng Songdong |
| 6 | MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B | 期刊论文 | Wang Saifeng; Zhang Xiaojun; Ju Ying; Zhao Bao; Yan Xiaoli; Hu Jun; Shi Lei; Yang Lebing; Ma Zhibo; Chen Lizhao; Liu Yali; Duan Zhongping; Chen Xinyue; Meng Songdong |
| 7 | 组织干细胞提取物及其制备方法和应用 | 专利 | 孟颂东;胡坤;陈立钊;王彦中;李星辉;赵报 |
| 8 | Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellular Carcinoma | 期刊论文 | Peng Zheng; Li Chang-Fei; Hao Jun-Li; Meng Song-Dong |
| 9 | Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer | 期刊论文 | Wu Bo;Chu Xiaoyu;Feng Cong;Hou Junwei;Fan Hongxia;Liu Ningning;Li Changfei;Kong Xianping;Ye Xin;Meng Songdong |
| 10 | 一种具有广谱交叉保护能力的流感通用疫苗及其制备方法 | 专利 | 孟颂东;鞠莹;胡俊;陈立钊;李长菲;赵报 |
| 11 | 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用 | 专利 | 孟颂东;侯军委;桂明明;赵报;陈立钊 |
| 12 | Endogenous Cellular microRNAs Mediate Antiviral Defense against Influenza A Virus | 期刊论文 | Shanxin Peng;Jing Wang;Songtao Wei;Changfei Li;Kai Zhou;Jun Hu;Xin Ye;Jinghua Yan;Wenjun Liu;George F Gao;Min Fang;Songdong Meng |
| 13 | Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion | 期刊论文 | Li Changfei; Wang Yanzhong; Wang Saifeng; Wu Bo; Hao Junli; Fan Hongxia; Ju Ying; Ding Yuping; Chen Lizhao; Chu Xiaoyu; Liu Wenjun; Ye Xin; Meng Songdong |
| 14 | Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels | 期刊论文 | Changfei Li;Mengmeng Deng;Jun Hu;Xin Li;Lizhao Chen;Ying Ju;Junli Hao;Songdong Meng |
| 15 | Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response | 期刊论文 | Liu Weiwei;Chen Mi;Li Xinghui;Zhao Bao;Hou Junwei;Zheng Huaguo;Qiu Lipeng;Li Zihai;Meng Songdong |
| 16 | A cross-talk between Hepatitis B virus and host mRNAs confers viral adaptation to liver | 期刊论文 | Hu Jun; Xu Yaxing; Li Changfei; Hao Junli; Peng Shanxin; Chu Xiaoyu; Zhang Dake; Xu Dongping; Meng Songdong |
| 17 | Placenta-derived gp96 as a multivalent prophylactic cancer vaccine | 期刊论文 | Zhao Bao; Wang Yanzhong; Wu Bo; Liu Shan; Wu Erjie; Fan HongXia; Gui MingMing; Chen Lizhao; Li Changfei; Ju Ying; Zhang Wei; Meng Songdong |
| 18 | Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR | 期刊论文 | Hou Junwei; Li Xin; Li Changfei; Sun Lu; Zhao Yulai; Zhao Jingmin; Meng Songdong |
| 19 | The L60V Variation in Hepatitis B Virus Core Protein Elicits New Epitope-Specific Cytotoxic T Lymphocytes and Enhances Viral Replication | 期刊论文 | Zhang Yu; Ren Yulin; Wu Yan; Zhao Bao; Qiu Lipeng; Li Xiaodong; Xu Dongping; Liu Jun; Gao George F.; Meng Songdong |
| 20 | Chaperone gp96 mediates ER-alpha 36 cell membrane expression | 期刊论文 | Hou Junwei; Deng Mengmeng; Li Xin; Liu Weiwei; Chu Xiaoyu; Wang Jing; Chen Feng; Meng Songdong |
| 21 | Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine | 期刊论文 | Ju Ying;Fan Hongxia;Liu Jun;Hu Jun;Li Xinghui;Li Changfei;Chen Lizhao;Gao Qiang;Gao George F.;Meng Songdong |
| 22 | Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer | 期刊论文 | Li Xin; Sun Lu; Hou Junwei; Gui Mingming; Ying Jianming; Zhao Hong; Lv Ning; Meng Songdong |
| 23 | Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma | 期刊论文 | Deng Mengmeng;Hou Junwei;Hu Jun;Wang Shuo;Chen Mi;Chen Lizhao;Ju Ying;Li Changfei;Meng Songdong |
| 24 | gp96蛋白的抗体在制备癌细胞抑制剂中的应用. | 专利 | 孟颂东;李鑫;李长菲;陈立钊;胡坤;武尔杰;赵报;鞠莹 |
| 25 | Induction of regulatory T cells by high-dose gp96 suppresses murine liver immune hyperactivation. | 期刊论文 | Li Xinghui;Liu Zhen;Yan Xiaoli;Zhang Xiaojun;Li Yang;Zhao Bao;Wang Shengdian;Zhou Xuyu;Gao George F;Meng Songdong |
| 26 | Blockage of Conformational Changes of Heat Shock Protein gp96 on Cell Membrane by a alpha-Helix Peptide Inhibits HER2 Dimerization and Signaling in Breast Cancer | 期刊论文 | Li Xin;Wang Baozhong;Liu Weiwei;Gui Mingming;Peng Zheng;Meng Songdong |
| 27 | Competitive virus and host RNAs: the interplay of a hidden virus and host interaction | 期刊论文 | Li Changfei; Hu Jun; Hao Junli; Zhao Bao; Wu Bo; Sun Lu; Peng Shanxin; Gao George F.; Meng Songdong |
| 28 | Increased Expression of Gp96 by HBx-Induced NF-kappa B Activation Feedback Enhances Hepatitis B Virus Production | 期刊论文 | Fan Hongxia; Yan Xiaoli; Zhang Yu; Zhang Xiaojun; Gao Yanzhou; Xu Yaxing; Wang Fusheng; Meng Songdong |
| 29 | Inhibition of Alpha Interferon (IFN-alpha)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-alpha | 期刊论文 | J. Hao; W. Jin; X. Li; S. Wang; X. Zhang; H. Fan; C. Li; L. Chen; B. Gao; G. Liu; S. Meng |
| 30 | PTD-fused p53 as a potential antiviral agent directly suppresses HBV transcription and expression. | 期刊论文 | Chu Xiaoyu;Wu Bo;Fan Hongxia;Hou Junwei;Hao Junli;Hu Jun;Wang Baozhong;Liu Guangze;Li Changfei;Meng Songdong |
| 31 | 人热休克蛋白gp96在制备筛查肝病的产品中的应用 | 专利 | 孟颂东;桂明明;赵报 |
| 32 | 一组gp96蛋白的多肽片段及其应用 | 专利 | 孟颂东;陈立钊;胡坤;李杨;李鑫;闫晓丽 |
| 33 | Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5 | 期刊论文 | Li Xin;Wu Bo;Chen Lizhao;Ju Ying;Li Changfei;Meng Songdong |
| 34 | 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用 | 专利 | 孟颂东;侯军委;桂明明;赵报;陈立钊 |
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