saRNA作为新型小核酸药物分子的机制和应用研究
81473128
2014
H3404.生物技术药物
梁子才
面上项目
教授
北京大学
80万元
生物制药;分子生物学;作用机制;小激活RNA
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs | 期刊论文 | Xinyun Song;Xiaoxia Wang;Yuan Ma;Zicai Liang;Zhenjun Yang;Huiqing Cao |
| 2 | Target-Recognition Mechanism and Specificity of RNA Activation | 专著 | Huiqing Cao;Xing Meng;Xiaoxia Wang;Zicai Liang |
| 3 | pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release | 期刊论文 | Junhui Zhou;Yidi Wu;Changrong Wang;Qiang Cheng;Shangcong Han;Xiaoxia Wang;Jianhua Zhang;Liandong Deng;Deyao Zhao;Lili Du;Huiqing Cao;Zicai Liang;Yuanyu Huang;Anjie Dong |
| 4 | Small activating RNA binds to the genomic target site in a seed-region-dependent manner | 期刊论文 | Xing Meng;Qian Jiang;Nanan Chang;Xiaoxia Wang;Chujun Liu;Jingwei Xiong;Huiqing Cao;Zicai Liang |
| 5 | Electroporation on microchips: the harmful effects of pH changes and scaling down. | 期刊论文 | Yang Li;Mengxi Wu;Deyao Zhao;Zewen Wei;Wenfeng Zhong;Xiaoxia Wang;Zicai Liang;Zhihong Li |
| 6 | The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers | 期刊论文 | Lili Du;Changrong Wang;Lingwei Meng;Qiang Cheng;Junhui Zhou;Xiaoxia Wang;Deyao Zhao;Jianhua Zhang;Liandong Deng;Zicai Liang;Anjie Dong;Huiqing Cao |
| 7 | The Promising Nanocarrier for Doxorubicin and siRNA Co-delivery by PDMAEMA-based Amphiphilic Nanomicelles | 期刊论文 | Qiang Cheng;Lili Du;Lingwei Meng;Shangcong Han;Tuo Wei;Xiaoxia Wang;Yidi Wu;Xinyun Song;Junhui Zhou;Shuquan Zheng;Yuanyu Huang;Xing-Jie Liang;Huiqing Cao;Anjie Dong;Zicai Liang |
| 8 | A Flow-Through Cell Electroporation Device for Rapidly and Efficiently Transfecting Massive Amounts of Cells in vitro and ex vivo | 期刊论文 | Deyao Zhao;Dong Huang;Yang Li;Mengxi Wu;Wenfeng Zhong;Qiang Cheng;Xiaoxia Wang;Yidi Wu;Xiao Zhou;Zewen Wei;Zhihong Li;Zicai Liang |
| 9 | Elaboration on the Distribution of Hydrophobic Segments in the Chains of Amphiphilic Cationic Polymers for Small Interfering RNA Delivery | 期刊论文 | Changrong Wang;Lili Du;Junhui Zhou;Lingwei Meng;Qiang Cheng;Changrong Wang;Xiaoxia Wang;Deyao Zhao;Yuanyu Huang;Shuquan Zheng;Huiqing Cao;Jianhua Zhang;Liandong Deng;Zicai Liang;Anjie Dong |
| 10 | The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy | 期刊论文 | Lili Du;Junhui Zhou;Lingwei Meng;Xiaoxia Wang;Changrong Wang;Yuanyu Huang;Shuquan Zheng;Liangdong Deng;Huiqing Cao;Zicai Liang;Anjie Dong;Qiang Cheng |
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