活性氧响应性材料的设计与合成及其释药系统在动脉粥样硬化治疗中的应用研究
81471774
2014
H2809.医用生物材料与仿生材料
张建祥
面上项目
教授
中国人民解放军第三军医大学
75万元
纳米载体;药物控释;药物载体;靶向治疗;动脉粥样硬化
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Multiple noncovalent interactions mediated one-pot therapeutic assemblies for the effective treatment of atherosclerosis | 期刊论文 | Dou Yin;Zhang Xiangjun;Xu Xiaoqiu;Zhou Xing;Han Songling;Wang Ruibing;Su Min;Li Xiaohui;Zhang Jianxiang |
| 2 | A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflammatory diseases | 期刊论文 | Guo Jiawei;Tao Hui;Dou Yin;Li Lanlan;Xu Xiaoqiu;Zhang Qixiong;Cheng Juan;Han Songling;Huang Jun;Li Xiaodong;Li Xiaohui;Zhang Jianxiang |
| 3 | 一种广谱活性氧簇清除性材料及其制备方法和应用 | 专利 | 张建祥;胡厚源;李兰兰;窦寅;王玉泉;张定林 |
| 4 | 一种具有化学发光成像功能的髓过氧化物酶响应性材料及其合成方法 | 专利 | 张建祥;郭嘉伟;陶辉;徐晓秋;窦寅 |
| 5 | 一种基于酵母微囊的口服靶向载体系统及其制备方法 | 专利 | 张建祥;李晓辉;周兴;窦寅;张相军;刘梦雨 |
| 6 | 炎症微环境响应性纳米药物、其制备方法及应用 | 专利 | 张建祥;胡厚源;窦寅;冯世斌;李晓辉;张相军 |
| 7 | Advanced emulsions via noncovalent interaction-mediated interfacial self-assembly | 期刊论文 | Han Songling;An Huijie;Tao Hui;Li Lanlan;Qi Yuantong;Ma Yongchang;Li Xiaohui;Wang Ruibing;Zhang Jianxiang |
| 8 | Structure-property correlations of reactive oxygen species-responsive and hydrogen peroxide-eliminating materials with anti-oxidant and anti-inflammatory activities | 期刊论文 | Zhang Qixiong;Zhang Fuzhong;Chen Yue;Dou Yin;Tao Hui;Zhang Dinglin;Wang Ruibing;Li Xiaohui;Zhang Jianxiang |
| 9 | Self-assembly of pH-responsive microspheres for intestinal delivery of diverse lipophilic therapeutics | 期刊论文 | Zhou Xing;Zhao Yang;Chen Siyu;Han Songling;Xu Xiaoqiu;Guo Jiawei;Liu Mengyu;Che Ling;Li Xiaohui;Zhang Jianxiang |
| 10 | 一种模拟超氧化物歧化酶/过氧化氢酶的纳米药物、制备方法及其应用 | 专利 | 张建祥;张齐雄;李晓辉 |
| 11 | A self-illuminating nanoparticle for inflammation imaging and cancer therapy | 期刊论文 | Xu Xiaoqiu;An Huijie;Zhang Dinglin;Tao Hui;Dou Yin;Li Xiaohui;Huang Jun;Zhang Jianxiang |
| 12 | A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease | 期刊论文 | Zhang Qixiong;Tao Hui;Lin Yongyao;Hu Ying;An Huijie;Zhang Dinglin;Feng Shibin;Hu Houyuan;Wang Ruibing;Li Xiaohui;Zhang Jianxiang |
| 13 | Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis | 期刊论文 | Dou Yin;Chen Yue;Zhang Xiangjun;Xu Xiaoqiu;Chen Yidan;Guo Jiawei;Zhang Dinglin;Wang Ruibing;Li Xiaohui;Zhang Jianxiang |
| 14 | Bioinspired yeast microcapsules loaded with self-assembled nanotherapies for targeted treatment of cardiovascular disease | 期刊论文 | Zhang Xiangjun;Xu Xiaoqiu;Chen Yidan;Dou Yin;Zhou Xing;Li Lanlan;Li Chenwen;An Huijie;Tao Hui;Hu Houyuan;Li Xiaohui;Zhang Jianxiang |
| 15 | A broad-spectrum ROS-eliminating material for prevention of inflammation and drug-induced organ toxicity | 期刊论文 | Li Lanlan;Guo Jiawei;Wang Yuquan;Xiong Xiaoxing;Tao Hui;Li Jin;Jia Yi;Hu Houyuan;Zhang Jianxiang |
| 16 | Yeast microcapsule-mediated targeted delivery of diverse nanoparticles for imaging and therapy via the oral route | 期刊论文 | Zhou Xing;Zhang Xiangjun;Han Songling;Dou Yin;Liu Mengyu;Zhang Lin;Guo Jiawei;Shi Qing;Gong Genghao;Wang Ruibing;Hu Jiang;Li Xiaohui;Zhang Jianxiang |
| 17 | 一种原位活性氧和髓过氧化物酶响应性自发光聚合物材料、制备方法及其应用 | 专利 | 张建祥;徐晓秋;安会杰;张定林;窦寅 |
| 18 | Multiscale and multifunctional emulsions by host-guest interaction-mediated self-assembly | 期刊论文 | Han Songling;Chen Siyu;Li Lanlan;Li Jin;An Huijie;Tao Hui;Jia Yi;Lu Shan;Wang Ruibing;Zhang Jianxiang |
| 19 | Facile assembly of cost-effective and locally applicable or injectable nanohemostats for hemorrhage control | 期刊论文 | Cheng Juan;Feng Shibin;Han Songling;Zhang Xiangjun;Chen Yidan;Zhou Xing;Wang Ruibing;Li Xiaohui;Hu Houyuan;Zhang Jianxiang |
| 20 | Nanoparticles responsive to the inflammatory microenvironment for targeted treatment of arterial restenosis | 期刊论文 | Feng Shibin;Hu Ying;Peng Song;Han Songling;Tao Hui;Zhang Qixiong;Xu Xiaoqiu;Zhang Jianxiang;Hu Houyuan |
| 21 | A facile route to diverse assemblies by host-guest recognition | 期刊论文 | Zhou Xing;Han Songling;Zhang Qixiong;Dou Yin;Guo Jiawei;Che Ling;Li Xiaohui;Zhang Jianxiang |
| 22 | Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells | 期刊论文 | Shi Qing;Zhang Lin;Liu Mengyu;Zhang Xuelin;Zhang Xiangjun;Xu Xiaoqiu;Chen Sha;Li Xiaohui;Zhang Jianxiang |
| 23 | Enhanced intracellular delivery and tissue retention of nanoparticles by mussel-inspired surface chemistry | 期刊论文 | Chen Kai;Xu Xiaoqiu;Guo Jiawei;Zhang Xuelin;Han Songling;Wang Ruibing;Li Xiaohui;Zhang Jianxiang |
| 24 | Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice | 期刊论文 | Dou Yin;Guo Jiawei;Chen Yue;Han Songling;Xu Xiaoqiu;Shi Qing;Jia Yi;Liu Ya;Deng Youcai;Wang Ruibing;Li Xiaohui;Zhang Jianxiang |
| 25 | A targeting nanotherapy for abdominal aortic aneurysms | 期刊论文 | Cheng Juan;Zhang Runjun;Li Chenwen;Tao Hui;Dou Yin;Wang Yuquan;Hu Houyuan;Zhang Jianxiang |
| 26 | Nanomaterial-dependent immunoregulation of dendritic cells and its effects on biological activities of contraceptive nanovaccines | 期刊论文 | Xu Pingping;Tang Shuai;Jiang Luping;Yang Lihua;Zhang Dinglin;Feng Shibin;Zhao Tingting;Dong Yajun;He Wei;Wang Ruibing;Zhang Jianxiang;Liang Zhiqing |
| 27 | Yeast capsules for targeted delivery: the future of nanotherapy? | 期刊论文 | Hu Xiankang;Zhang Jianxiang |
| 28 | Self-assembly of pH-responsive microspheres for intestinal delivery of diverse lipophilic therapeutics | 期刊论文 | Zhou Xing;Zhao Yang;Chen Siyu;Han Songling;Xu Xiaoqiu;Guo Jiawei;Liu Mengyu;Che Ling;Li Xiaohui;Zhang Jianxiang |
| 29 | Facile assembly of cost-effective and locally applicable or injectable nanohemostats for hemorrhage control | 期刊论文 | Cheng Juan;Feng Shibin;Han Songling;Zhang Xiangjun;Chen Yidan;Zhou Xing;Wang Ruibing;Li Xiaohui;Hu Houyuan;Zhang Jianxiang |
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