lncRNA编程介导的宫内不良营养环境导致子代糖脂代谢紊乱的跨代机制

81870545
2018
H0708.糖尿病
张茜
面上项目
副研究员
中国医学科学院北京协和医院
57万元
长链非编码RNA;糖脂代谢紊乱;宫内营养;表观遗传学
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A possible mechanism: genistein improves metabolusm and induces whithe fat browning through modulating hypothalamic expression of Ucn3, Depp,m and Stc1 会议论文 周丽媛;肖新华;张茜;黎明;邓明群;刘洁颖
2 High-fat diet alters diurnal rhythm of hepatic clock and microbiota-derived short-chain fatty acids in gestational mice 会议论文 丁露;肖新华;刘洁颖;周丽媛;李舜华;张茜;黎明;于淼;许建萍
3 Prebiotic Early Intervention Improves Blood Glucose in Pup Mice 会议论文 张茜;肖新华;黎明
4 Early-life genistein intake improves glucose and lipid metabolusm and modulates gut microbiota in adult male mice 会议论文 周丽媛;肖新华;张茜;郑佳;邓明群
5 生命早期染料木黄酮摄入可改善成年小鼠糖脂代谢紊乱并调节肠道菌群 会议论文 周丽媛;肖新华;张茜;黎明;刘洁颖;邓明群
6 Potential benefits of metformin and pioglitazone combination therapy via gut microbiota and metabolites in high-fat diet-fed mice 期刊论文 王冬梅;刘洁颖;钟玲;丁露;张茜;于淼;黎明;肖新华
7 甜菜碱介导妊娠期糖尿病致子代糖脂代谢异常 会议论文 刘洁颖;翟笑;付俊玲;周丽媛;丁露;邓明群;于淼;张茜;肖新华
8 A high-fat diet disrupts the hepatic and adipose circadian rhythms and modulates the diurnal rhythm of gut microbiota-derived short-chain fatty acids in gestational mice 期刊论文 丁露;刘洁颖;周丽媛;贾鑫淼;李舜华;张茜;于淼;肖新华
9 Maternal Genistein Intake Mitigates the Deleterious Effects of High-Fat Diet on Glucose and Lipid Metabolism and Modulates Gut Microbiota in Adult Life of Male Mice 期刊论文 周丽媛;肖新华;张茜;郑佳;邓明群
10 A Possible Mechanism: Genistein Improves Metabolism and Induces White Fat Browning Through Modulating Hypothalamic Expression of Ucn3, Depp, and Stc1 期刊论文 周丽媛;肖新华;张茜;郑佳;黎明;邓明群
11 Programming effects of maternal high-fat diet on offspring metabolism: the role of circadian rhythms of gut microbiota 会议论文 丁露;刘洁颖;周丽媛;于淼;张茜;肖新华
12 Comparing the Efficacy and Safety of Glucagon-Like Peptide 1 Receptor Agonists with Sodium-Glucose Cotransporter 2 Inhibitors for Obese Type 2 Diabetes Patients Uncontrolled on Metformin: A Systematic Review and Meta-Analysis of Randomized Clinical Trials 期刊论文 丁露;孙邦;肖新华
13 妊娠期糖尿病孕妇外周血及新生儿脐血血浆中甜菜碱水平与糖代谢关系的研究 期刊论文 翟笑;刘洁颖;李融融;刘俊涛;宋英娜;马良坤;乔宗旭;赵贵芬;王瑞平;张茜;邓明群;付俊玲;周丽媛;肖新华
14 Maternal High-fat Diet Disturbs the DNA Methylation Profile in the Brown Adipose Tissue of Offspring Mice 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
15 母代甜菜碱摄入对母体及子代糖脂代谢的影响及肠道菌群的作用研究 会议论文 刘洁颖;丁露;翟笑;周丽媛;肖诚;王冬梅;于淼;张茜;肖新华
16 生命早期益生元干预改善糖代谢及其甲基化机制 会议论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
17 在二甲双胍单药治疗血糖控制不佳的 2 型糖尿病患者中 比较 GLP-1 受体激动剂和 SGLT-2 抑制剂控制血糖的疗效 与安全性—— 一项基于随机对照试验的 Meta 分析 会议论文 丁露;肖新华
18 Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARa pathway in diabetic rats 期刊论文 张茜;肖新华;黎明;于淼;平凡
19 遗传性内分泌代谢疾病新型诊疗体系的建立及应用 奖励 夏维波;伍学焱;肖新华;李梅;章振林;王鸥;邢小平;张茜;赵秀丽;聂敏;童安莉;茅江峰;李玉秀;于淼
20 遗传性内分泌代谢疾病 专著 夏维波;李梅;朱惠娟;李玉秀;聂敏;张茜
21 “肠道菌群-肝脏生物钟轴”调控孕鼠肥胖和糖代谢异常的作用研究 会议论文 丁露;肖新华;刘洁颖;周丽媛;李舜华;张茜;黎明;于淼;许建萍
22 MODY2患者HDLs局部富集CEPT1和ATGL使HDL-PCps增加有助于 抗动脉粥样硬化作用 会议论文 王晓晶;Sin Man Lam;王彤;王志新;许建萍;李博文;张化冰;平凡;宋光耀;冯凯;张茜;肖新华
23 A glucagon-like peptide-1 analog, liraglutide, ameliorates endothelial dysfunction through miRNAs to inhibit apoptosis in rats 期刊论文 张茜;肖新华;郑佳;黎明
24 Qishen Yiqi Dripping Pill protects against diabetic nephropathy by inhibiting the Wnt/β-catenin and TGF-β/Smad signaling pathways in rats 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
25 Non-coding RNAs: The link between maternal malnutrition and offspring metabolism 期刊论文 曾缘;吴伊凡;张茜;肖新华
26 Improvement in glucose metabolism in adult male offspring of maternal mice fed diets supplemented with inulin via regulation of the hepatic long noncoding RNA profile 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
27 “肠道菌群-肝脏轴”在母代运动干预对子代糖脂代谢影响中的作用 会议论文 周丽媛;肖新华;张茜;邓明群
28 Gut Microbiota-Circadian Clock Axis" in Deciphering the Mechanism Linking Early-Life Nutritional Environment and Abnormal Glucose Metabolism 期刊论文 周丽媛;康林;肖新华;贾黎静;张茜;邓明群
29 Dietary genistein modulates hypothalamic circadian entrainment, reduces body weight and improves metabolism in mice 会议论文 周丽媛;肖新华;张茜;郑佳;邓明群;刘洁颖
30 Early-life nutrition and metabolic disorders in later life: a new perspective on energy metabolism 期刊论文 周丽媛;邓明群;张茜;肖新华
31 Shenqi Jiangtang Granule Ameliorates Kidney Function by Inhibiting Apoptosis in a Diabetic Rat Model 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
32 Vildagliptin, a dipeptidyl peptidase-4 inhibitor, attenuated endothelial dysfunction through miRNAs in diabetic rats 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
33 Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery 期刊论文 周丽媛;邓明群;肖新华
34 小于胎龄儿母婴血浆中甜菜碱的水平及其与孕妇糖代谢的关系 期刊论文 翟笑;刘洁颖;李融融;刘俊涛;宋英娜;马良坤;乔宗旭;赵贵芬;王瑞平;张茜;邓明群;付俊玲;周丽媛;赵楠;宋玮;肖新华
35 Influence of Maternal Inulin-Type Prebiotic Intervention on Glucose Metabolism and Gut Microbiota in the Offspring of C57BL Mice 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
36 Genistein regulates metabolism and white fat browning through modulating hypothalamic expression of Ucn3, Depp and Stc1 会议论文 周丽媛;肖新华;张茜;郑佳
37 Deciphering the Anti-obesity Benefits of Resveratrol: The "Gut Microbiota-Adipose Tissue" Axis 期刊论文 周丽媛;肖新华;张茜;郑佳;邓明群
38 Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring 期刊论文 周丽媛;肖新华;张茜;郑佳;黎明;王晓晶;邓明群;翟笑;刘洁颖
39 Genistein improves glucose metabolism and promotes adipose tissue browning through modulating gut microbiota in mice 期刊论文 李舜华;周丽媛;张茜;于淼;肖新华
40 母代高脂饮食对子代生命不同阶段糖脂代谢节律的影响及肠道菌群昼夜节律的作用 会议论文 丁露;刘洁颖;周丽媛;于淼;张茜;肖新华
41 Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites 期刊论文 王冬梅;刘洁颖;周丽媛;张茜;黎明;肖新华
42 母代运动干预通过miRNA调控子代成年期糖脂代谢 会议论文 周丽媛;张茜;于淼;肖新华
43 Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus 期刊论文 丁露;肖新华
44 Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice 期刊论文 周丽媛;肖新华;张茜;郑佳;黎明;于淼;王晓晶;邓明群;翟笑;李融融;刘洁颖
45 Maternal Inulin Supplementation Alters Hepatic DNA Methylation Profile and Improves Glucose Metabolism in Offspring Mice 期刊论文 张茜;肖新华;郑佳;黎明;于淼;王彤;王晓晶
46 The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: an Emerging Field 期刊论文 吴伊凡;张茜;肖新华
47 A Maternal High-Fat Diet Induces DNA Methylation Changes That Contribute to Glucose Intolerance in Offspring 期刊论文 张茜;肖新华;郑佳;黎明;于淼;平凡;王彤;王晓晶
48 Potential Contributions of Gut Microbiota-Liver Axis to the Transgenerational Metabolic Reprogramming of Maternal Exercise 会议论文 周丽媛;肖新华;张茜;黎明
49 一种区分MODY与T1D和T2D的诊断试剂盒和诊断系统 专利 付俊玲;肖新华;平凡;王彤;张茜;于淼;虞睿琪
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