烟酰胺核苷酸转氢酶激活的脂质棕色化在肾透明细胞癌 HIF2α致癌通路中的功能及机制研究
81972630
2019
H1807.肿瘤代谢
杨红枚
面上项目
教授
华中科技大学
57万元
烟酰胺核苷酸转氢酶;致癌能力;脂质棕色化;缺氧诱导因子2α;肾透明细胞癌
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | HIF2α promotes tumour growth in clear cell renal cell carcinoma by increasing the expression of NUDT1 to reduce oxidative stress | 期刊论文 | Jian Shi;Zhiyong Xiong;Keshan Wang;Changfei Yuan;Yu Huang;Wen Xiao;Xiangui Meng;Zhixian Chen;Qingyang Lv;Daojia Miao;Huageng Liang;Tianbo Xu;Kairu Xie;Hongmei Yang;Xiaoping Zhang |
| 2 | LINC00160 mediates sunitinib resistance in renal cell carcinoma via SAA1 that is implicated in STAT3 activation and compound transportation............. | 期刊论文 | Gong Cheng;Yuenan Liu;Lilong Liu;Hailong Ruan;Qi Cao;Zhengshuai Song;Lin Bao;Tianbo Xu;Zhiyong Xiong;Jingchong Liu;Di Liu;Huageng Liang;Guosong Jiang;Xiong Yang;Hongmei Yang;Ke Chen;Xiaoping Zhang |
| 3 | NNT‐induced tumor cell “slimming” reverses the pro‐carcinogenesis effect of HIF2a in tumors | 期刊论文 | Zhiyong Xiong;Wei Xiong;Wen Xiao;Changfei Yuan;Jian Shi;Yu Huang;Cheng Wang;Xiangui Meng;Zhixian Chen;Hongmei Yang;Ke Chen;Xiaoping Zhang |
| 4 | As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner | 期刊论文 | Daojia Miao;Jian Shi;Zhiyong Xiong;Wen Xiao;Xiangui Meng;Qingyang Lv;Kairu Xie;Hongmei Yang;Xiaoping Zhang |
| 5 | TIMP1 Indicates Poor Prognosis of Renal Cell Carcinoma and Accelerates Tumorigenesis via EMT Signaling Pathway | 期刊论文 | Yi Shou;Yuenan Liu;Jiaju Xu;Jingchong Liu;Tianbo Xu;Junwei Tong;Lilong Liu;Yaxin Hou;Di Liu;Hongmei Yang;Gong Cheng;Xiaoping Zhang |
| 6 | The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling............. | 期刊论文 | Jian Shi;Daojia Miao;Qingyang Lv;Keshan Wang;Qi Wang;Huageng Liang;Hongmei Yang;Zhiyong Xiong;Xiaoping Zhang |
| 7 | circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma............. | 期刊论文 | Yuenan Liu;Kailei Chen;Yi Shou;Sen Li;Jun Wang;Qingyang Zhang;Ziwei Huang;Jiaju Xu;Mingfeng Li;Di Liu;Huageng Liang;Hongmei Yang;Xiaoping Zhang |
| 8 | 肾癌诊疗关键技术创新及应用 | 奖励 | 章小平;郭剑明;那彦群;张旭明;谌科;汪磊;梁华庚;YANGHONGMEI;肖文;熊之勇;肖亚军;刘磊;阮海龙;曹琪;赵子臣 |
| 9 | A Fatty Acid Metabolism Signature Associated With Clinical Therapy in Clear Cell Renal Cell Carcinoma | 期刊论文 | Zhihao Wei;Gong Cheng;Yuzhong Ye;Changjie Le;Qi Miao;Jiawei Chen;Hongmei Yang;Xiaoping Zhang |
| 10 | Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia | 期刊论文 | Hairong Xiong;Jiaxin Ye;Qianqian Luo;Wen Li;Ning Xu;Hongmei Yang |
| 11 | Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway | 期刊论文 | Hairong Xiong;Jiaxin Ye;Kairu Xie;Wenjun Hu;Ning Xu;Hongmei Yang |
| 12 | Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia | 期刊论文 | Kairu Xie;Hairong Xiong;Wen Xiao;Zhiyong Xiong;Wenjun Hu;Jiaxin Ye;Ning Xu;Jian Shi;Changfei Yuan;Zhixian Chen;Daojia Miao;Xiaoping Zhang;Hongmei Yang |
| 13 | Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress | 期刊论文 | Xiong Zhiyong;Yuan Changfei;Shi Jian;Xiong Wei;Huang Yu;Xiao Wen;Yang Hongmei;Chen Ke;Zhang Xiaoping |
| 14 | Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis | 期刊论文 | Chunxiang Feng;Zhiyong Xiong;Cheng Wang;Wen Xiao;Haibing Xiao;Kairu Xie;Ke Chen;Huageng Liang;Xiaoping Zhang;Hongmei Yang |
| 15 | Downregulation of ubiquitin-specific protease 2 possesses prognostic and diagnostic value and promotes the clear cell renal cell carcinoma progression............. | 期刊论文 | Xiangui Meng;Zhiyong Xiong;Wen Xiao;Changfei Yuan;Cheng Wang;Yu Huang;Junwei Tong;Jian Shi;Zhixian Chen;Chenchen Liu;Kairu Xie;Hailong Xiong;Ke Chen;Hongmei Yang;Xiaoping Zhang |
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