FBXO22调控组蛋白去甲基化酶KDM4C泛素化降解增强肺癌放疗敏感性的作用机制研究
81874218
2018
H1821.肿瘤治疗抵抗
伍钢
面上项目
教授
华中科技大学
57万元
肺肿瘤;FBXO22;C05_气管;支气管;泛素化;放疗敏感性;KDM4C
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Polymorphonuclear-MDSCs Facilitate Tumor Regrowth After Radiation by Suppressing CD8+ T Cells | 期刊论文 | Jieying Zhang;Liling Zhang;Yuhui Yang;Qing Liu;Hong Ma;Ai Huang;Yanxia Zhao;Zihan Xia;Tao Liu;Gang Wu |
| 2 | Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer | 期刊论文 | Xiaohua Jie;Yunshang Chen;Ye Zhao;Xijie Yang;Yingzhuo Xu;Jian Wang;Rui Meng;Sheng Zhang;Xiaorong Dong;Tao Zhang;Kunyu Yang;Shuangbing Xu;Gang Wu |
| 3 | BRD4‐IRF1 axis regulates chemoradiotherapy‐induced PD‐L1 expression and immune evasion in non‐small cell lung cancer | 期刊论文 | Jian Wang;Yingzhuo Xu;Xinrui Rao;Ruiguang Zhang;Jing Tang;Dan Zhang;Xiaohua Jie;Kuikui Zhu;Xu Wang;Yunhong Xu;Sheng Zhang;Xiaorong Dong;Tao Zhang;Kunyu Yang;Shuangbing Xu;Rui Meng;Gang Wu |
| 4 | UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance | 期刊论文 | Yumei Huang;Xijie Yang;Yanwei Lu;Ye Zhao;Rui Meng;Sheng Zhang;Xiaorong Dong;Shuangbing Xu;Gang Wu |
| 5 | USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription | 期刊论文 | Xiaohua Jie;William Pat Fong;Rui Zhou;Ye Zhao;Yingchao Zhao;Rui Meng;Sheng Zhang;Xiaorong Dong;Tao Zhang;Kunyu Yang;Gang Wu;Shuangbing Xu |
| 6 | 表观遗传学在肿瘤放射性DNA损伤修复中的研究进展 | 期刊论文 | 揭小华;徐双兵;伍钢 |
| 7 | REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis | 期刊论文 | Yunshang Chen;Xiaohua Jie;Biyuan Xing;Zilong Wu;Xijie Yang;Xinrui Rao;Yingzhuo Xu;Dong Zhou;Xiaorong Dong;Tao Zhang;Kunyu Yang;Zhenyu Li;Gang Wu |
| 8 | Activated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer | 期刊论文 | Xiaoshu Zhou;Rui Zhou;Xinrui Rao;Jiaxin Hong;Qianwen Li;Xiaohua Jie;Jian Wang;Yingzhuo Xu;Kuikui Zhu;Zhenyu Li;Gang Wu |
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