DACH1与EGFR-STAT3信号的交互作用调控三阴性乳腺癌恶性生物学行为

81874120
2018
H1819.肿瘤生物治疗
吴孔明
面上项目
教授
华中科技大学
57万元
STAT3;肿瘤干细胞;表皮生长因子受体;乳腺肿瘤;上皮-间质转换
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 CD38: targeted therapy in multiple myeloma and therapeutic potential for solid cancers 期刊论文 Jiao Y;Yi M;Xu L;Ch Q;Yan Y;Luo S;Wu K
2 The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-βand PD-L1 期刊论文 Yi M;Zhang J;Niu M;Yan Y;Jiao Y;Luo S;Zhou P;Wu K
3 MiRNA-mediated EMT and CSCs in cancer 期刊论文 Dong B;Li S;Zhu S;Yi M;Luo S;Wu K
4 Organoid technology and applications in cancer research 期刊论文 Xu H;Lyu X;Yi M;Zhao W;Song Y;Wu K
5 EYA2 Correlates with Clinico-Pathological Features of Breast Cancer, Promotes Tumor Proliferation, and Predicts Poor Survival 期刊论文 Xu H;Jiao Y;Yi M;Zhao W;Wu K
6 Biological characteristics and clinical significance of soluble PD-1/PD-L1 and exosomal PD-L1 in cancer 期刊论文 Niu M;Liu Y;Yi M;Jiao D;Wu K
7 Next Generation Chimeric Antigen Receptor T Cells: Toxicities and Safety Strategies 期刊论文 Yu S;Yi M;Qin S;Wu K
8 Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma 期刊论文 Qin S;Yi M;Jiao D;Li A;Wu K
9 Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC 期刊论文 Niu M;Yi M;Luo S;Wu K
10 Prognostic values of TIM-3 expression in patients with solid tumors: a meta-analysis and database evaluation 期刊论文 Qin S;Dong B;Yi M;Chu Q;Wu K
11 Roles of tumor-associated macrophages in tumor progression:implication on therapeutic strategies 期刊论文 Zhu S;Yi M;Wu Y;Dong B;Wu K
12 Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy 期刊论文 Wu Y;Yi M;Niu M;Mei Q;Wu K
13 Tumor organoids: Applications in cancer modeling and potentials in precision medicine 期刊论文 Xu H;Jiao D;Liu A;Wu K
14 The roles of exosomes in cancer drug resistance and its therapeutic application 期刊论文 Li S;Yi M;Dong B;Jiao Y;Luo S;Wu K
15 NRF2-Driven KEAP1 Transcription in Human Lung Cancer 期刊论文 Tian Y;Liu Q;Yu S;Ch Q;Chen Y;Wu K;Wang L
16 Immune signature-based risk stratification and prediction of immune checkpoint inhibitor's efficacy for lung adenocarcinoma 期刊论文 Yi M;Li A;Zhou L;Chu Q;Luo S;Wu K
17 Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors 期刊论文 Yi M;Niu M;Wu Y;Ge H;Jiao D;Zhu S;Zhang J;Yan Y;Zhou P;Chu Q;Wu K
18 Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy 期刊论文 Li A;Yi M;Qin S;Song Y;Chu Q;Wu K
19 CXCL1 as an Unfavorable Prognosis Factor Negatively Regulated by DACH1 in Non-small Cell Lung Cancer 期刊论文 Yu S;Yi M;Xu L;Qin S;Li A;Wu K
20 The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global burden of disease study 2017 期刊论文 Yi M;Li A;Zhou L;Chu Q;Song Y;Wu K
21 Advances of targeted therapy for hepatocellular carcinoma 期刊论文 Niu M;Yi M;Li N;Wu KJ;Wu K
22 Dachshund depletion disrupts mammary gland development and diverts the composition of the mammary gland progenitor pool 期刊论文 Jiao X;Li Z;Wang M;Katiyar S;Di Sante G;Farshchian M;Andrew P;South AP;Mardon G;Cocola C;Colombo D;Reinbold R;Zucchi I;Wu K;Tabas I;Spike BT;Pestell RG
23 CD44 as a tumor biomarker and therapeutic target 期刊论文 Xu H;Niu M;Yuan X;Wu K;Liu A
24 SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1 期刊论文 Kong D;Li A;Liu Y;Cui Q;Wang K;Zhang D;Tang J;Du Y;Liu Z;Wu G;Wu K
25 Anti-TGF-β/PD-­L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-­ negative breast cancer 期刊论文 Yi M;Wu Y;Niu M;Zhu S;Zhang J;Yan Y;Zhu P;Dai Z;Wu K
26 Roles of Microvesicles in Tumor Progression and Clinical Applications 期刊论文 Zhu S;Li S;Yi M;Li N;Wu K
27 Identifying Tumorigenesis and Prognosis-Related Genes of Lung Adenocarcinoma: Based on Weighted Gene Coexpression Network Analysis 期刊论文 Yi M;Li T;Qin S;Chu Q;Li A;Wu K
28 Blocking TGF-β signaling to enhance the efficacy of immune checkpoint inhibitor 期刊论文 Bai X;Yi M;Jiao Y;Chu Q;Wu K
29 Prospects for combining immune checkpoint blockade with PARP inhibition 期刊论文 Li A;Yi M;Qin S;Song Y;Chu Q;Luo S;Wu K
30 Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers 期刊论文 Yi M;Niu M;Zhang J;Li S;Zhu S;Yan Y;Li N;Zhou P;Wu K
31 Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy 期刊论文 Qin S;Li A;Yi M;Yu S;Zhnag M;Wu K
32 Manipulating gut microbiota composition to enhance the therapeutic effect of cancer immunotherapy 期刊论文 Yi M;Jiao D;Qin S;Chu Q;Li A;Wu K
33 The efficacy and safety of combination of PD-1 and CTLA-4 inhibitors: a meta-analysis 期刊论文 Wu K;Yi M;Qin S;Chu Q;Zheng X;Wu K
34 Advances and perspectives of PARP inhibitors 期刊论文 Yi M;Dong B;Qin S;Chu Q;Wu K;Luo S
35 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity 期刊论文 Yan Y;Huang L;Liu Y;Yi M;Chu Q;Jiao D;Wu K
36 Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment 期刊论文 Yi M;Jiao D;Qin S;Chu Q;Wu K;Li A
37 Immune pressures drive the promoter hypermethylation of neoantigen genes 期刊论文 Yi M;Dong B;Chu Q;Wu K
38 Recent advances and challenges of bispecific antibodies in solid tumors 期刊论文 Wu Y;Yi M;Zhu S;Wang H;Wu K
39 The role of exosomes in liquid biopsy for cancer diagnosis and prognosis prediction 期刊论文 Li S;Yi M;Dong B;Tian X;Luo S;Wu K
40 Combination strategies with PD-1/PD-L1 blockade: current advances and future directions 期刊论文 Yi M;Zheng X;Niu M;Zhu S;Ge H;Wu K
41 Progression and prognostic value of ECT2 in non-small-cell lung cancer and its correlation with PCNA 期刊论文 Bai X;Yi M;Xia X;Yu S;Zheng X;Wu K
42 RDGN-based predictive model for the prognosis of breast cancer 期刊论文 Dong B;Yi M;Luo S;Li A;Wu K
43 Regulation of PD-L1 expression in the tumor microenvironment 期刊论文 Yi M;Niu M;Xu L;Luo S;Wu K
44 Global burden and trend of acute lymphoblastic leukemia from 1990 to 2017 期刊论文 Yi M;Zhou L;Li A;Luo S;Wu K
45 Epidemiological trends of women's cancers from 1990 to 2019 at the global, regional, and national levels: a population-based study 期刊论文 Yi M;Li T;Niu M;Luo S;Chu Q;Wu K
46 Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer and promotes the proliferation of colon cancer cells 期刊论文 Niu M;Yi M;Dong B;Luo S;Wu K
47 The role of cancer-derived microRNAs in cancer immune escape 期刊论文 Yi M;Xu L;Jiao Y;Luo S;Li A;Wu K
48 The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017 期刊论文 Bai X;Yi M;Dong B;Zheng X;Wu K
49 Prognostic significance of KRT19 in lung squamous cancer 期刊论文 Yuan X;Yi M;Dong B;Ch Q;Wu K
50 Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 期刊论文 Qin S;Xu L;Yi M;YU S;Wu K;Luo S
51 A Novel Asymmetrical Anti-HER2/CD3 Bispecific Antibody Exhibits Potent Cytotoxicity for HER2-positive Tumor Cells 期刊论文 Yu S;Zhang J;Yan Y;Yao X;Fang L;Xiong H;Liu Y;Chu Q;Zhou P;Wu K
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