E2/E3泛素杂合酶UBE2O调控Mxi1泛素化降解促进肺癌放疗抵抗的作用机制研究

81874041
2018
H1821.肿瘤治疗抵抗
徐双兵
面上项目
教授
华中科技大学
60万元
肺肿瘤;放疗抵抗;Mxi1;泛素化;UBE2O
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Arginine methyltransferase PRMT5 methylates and destabilizes Mxi1 to confer radioresistance in non-small cell lung cancer 期刊论文 Xijie Yang;Zhen Zeng;Xiaohua Jie;Ye Wang;Jun Han;Zhikun Zheng;Jinsong Li;Hongli Liu;Xiaorong Dong;Gang Wu;Shuangbing Xu
2 β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma 期刊论文 Yanwei Lu;Xudong Li;Hongli Liu;Jun Xue;Zhen Zeng;Xiaorong Dong;Tao Zhang;Gang Wu;Kunyu Yang;Shuangbing Xu
3 Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer 期刊论文 Xiaohua Jie;Yunshang Chen;Ye Zhao;Xijie Yang;Yingzhuo Xu;Jian Wang;Rui Meng;Sheng Zhang;Xiaorong Dong;Tao Zhang;Kunyu Yang;Shuangbing Xu;Gang Wu
4 CDK5 activates Hippo signaling to confer resistance to radiation therapy via upregulating TAZ in lung cancer 期刊论文 Yulan Zeng;Quan Liu;Ye Wang;Chen Tian;Qifan Yang;Ye Zhao;Li Liu;Gang Wu;Shuangbing Xu
5 IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer 期刊论文 Yulan Zeng;Xiaohua Jie;Bian Wu;Gang Wu;Li Liu;Shuangbing Xu
6 UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance 期刊论文 Yumei Huang;Xijie Yang;Yanwei Lu;Ye Zhao;Rui Meng;Sheng Zhang;Xiaorong Dong;Shuangbing Xu;Gang Wu
7 Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer 期刊论文 Tie Xu;Yulan Zeng;Linli Shi;Qin Yang;Yeshan Chen;Gang Wu;Guiling Li;Shuangbing Xu
8 USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription 期刊论文 Xiaohua Jie;William Pat Fong;Rui Zhou;Ye Zhao;Yingchao Zhao;Rui Meng;Sheng Zhang;Xiaorong Dong;Tao Zhang;Kunyu Yang;Gang Wu;Shuangbing Xu
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