TFEB介导溶酶体功能障碍在PBDE-47发育神经毒性中作用及机制研究

81773388
2017
H3001.环境卫生
王爱国
面上项目
教授
华中科技大学
60万元
分子机制;溶酶体功能障碍;发育神经毒性;转录因子EB;PBDE-47
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ERK1/2-mediated disruption of BDNF–TrkB signaling causes synaptic impairment contributing to fluoride–induced developmental neurotoxicity 期刊论文 Jingwen Chen;Qiang Niu;Tao Xia;Guoyu Zhou;Pei Li;Qian Zhao;Chunyan Xu;Lixin Dong;Shun Zhang;Aiguo Wang
2 Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children 期刊论文 Mengwei Wang;Ling Liu;Huijun Li;Yonggang Li;Hongliang Liu;Changchun Hou;Qiang Zeng;Pei Li;Qian Zhao;Lixin Dong;Xingchen Yu;Li Liu;Qing Guan;Shun Zhang;Aiguo Wang
3 Low-moderate fluoride exposure and intelligence among Chinese school-aged children: Role of circulating mtDNA content. 期刊论文 Guoyu Zhou;Qian Zhao;Chen Luo;Hongliang Liu;Pei Li;Yushan Cui;Xingchen Yu;Jingwen Chen;Li Liu;Shun Zhang;Aiguo Wang
4 The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. 期刊论文 Sumei Wang;Qian Zhao;Gaochun Li;Mengwei Wang;Hongliang Liu;Xingchen Yu;Jingwen Chen;Pei Li;Lixin Dong;Guoyu Zhou;Yushan Cui;Mengru Wang;Li Liu;Aiguo Wang
5 Low-to-moderate fluoride exposure, relative mitochondrial DNA levels, and dental fluorosis in Chinese children 期刊论文 Guoyu Zhou;Lu Yang;Chen Luo;Hongliang Liu;Pei Li;Yushan Cui;Li Liu;Xingchen Yu;Qiang Zeng;Jingwen Chen;Qian Zhao;Lixin Dong;Qiang Niu;Shun Zhang;Aiguo Wang
6 Effects of long-term fluoride exposure on cognitive ability and the underlying mechanisms: Role of autophagy and its association with apoptosis 期刊论文 Guoyu Zhou;Sha Tang;Lu Yang;Qian Niu;Jingwen Chen;Tao Xia;Sumei Wang;Mengwei Wang;Qian Zhao;Ling Liu;Pei Li;Lixin Dong;Kedi Yang;Shun Zhang;Aiguo Wang
7 SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride 期刊论文 Qian Zhao;Zhiyuan Tian;Guoyu Zhou;Qiang Niu;Jingwen Chen;Pei Li;Lixin Dong;Tao Xia;Shun Zhang;Aiguo Wang
8 Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis 期刊论文 Lixin Dong;Pei Li;Kaichao Yang;Luming Liu;Hui Gao;Guoyu Zhou;Qian Zhao;Tao Xia;Aiguo Wang;Shun Zhang
9 TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion 期刊论文 Huayang Tang;Haoying Huang;Dan Wang;Pei Li;Zhiyuan Tian;Dongjie Li;Sumei Wang;Rulin Ma;Tao Xia;Aiguo Wang
10 Autophagy impairment contributes to PBDE-47-induced developmental neurotoxicity and its relationship with apoptosis 期刊论文 Pei Li;Rulin Ma;Lixin Dong;Luming Liu;Guoyu Zhou;Zhiyuan Tian;Qian Zhao;Tao Xia;Shun Zhang;Aiguo Wang
11 Impaired sperm quantity and motility in adult rats following gestational and lactational exposure to environmentally relevant levels of PBDE-47: A potential role of thyroid hormones disruption 期刊论文 Xiaoning Li;Hui Gao;Pei Li;Wei Chen;Sha Tang;Luming Liu;Guoyu Zhou;Tao Xia;Aiguo Wang;Shun Zhang
12 Low-to-moderate fluoride exposure in relation to overweight and obesity among school-age children in China 期刊论文 Ling Liu;Mengwei Wang;Yonggang Li;Hongliang Liu;Changchun Hou;Qiang Zeng;Pei Li;Qian Zhao;Lixin Dong;Xingchen Yu;Li Liu;Shun Zhang;Aiguo Wang
13 Perigestational low-dose BDE-47 exposure alters maternal serum metabolome and results in sex-specific weight gain in adult offspring 期刊论文 Hui Gao;Pei Li;Luming Liu;Kaichao Yang;Boya Xiao;Guoyu Zhou;Zhiyuan Tian;Chen Luo;Tao Xia;Lixin Dong;Qian Zhao;Aiguo Wang;Shun Zhang
14 Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity 期刊论文 Pei Li;Luming Liu;Guoyu Zhou;Zhiyuan Tian;Chen Luo;Tao Xia;Jingwen Chen;Qiang Niu;Lixin Dong;Qian Zhao;Aiguo Wang;Shun Zhang
15 Perinatal low-dose PBDE-47 exposure hampered thyroglobulin turnover and induced thyroid cell apoptosis by triggering ER stress and lysosomal destabilization contributing to thyroid toxicity in adult female rats 期刊论文 Pei Li;Hui Gao;Lixin Dong;Luming Liu;Guoyu Zhou;Chen Luo;Zhiyuan Tian;Tao Xia;Aiguo Wang;Shun Zhang
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