DDR1-p53调控途径对血管衰老过程中平滑肌细胞DNA甲基化的影响机制
91949112
2019
H0211.血管发生及血管结构与功能异常
周菁
重大研究计划
研究员
北京大学
68万元
机械力信号转导;平滑肌细胞;细胞外基质刚度;血管衰老;DNA甲基化
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis | 期刊论文 | Jin Wang;Si-an Xie;Ning Li;Tao Zhang;Weijuan Yao;Hucheng Zhao;Wei Pang;Lili Han;Jiayu Liu;Jing Zhou |
| 2 | Vitexin Inhibits APEX1 to Counteract the Flow-Induced Endothelial Inflammation | 期刊论文 | CR Zhao;FF Yang;Q Cui;D Wang;Y Zhou;Y-S Li;YP Zhang;RZ Tang;WJ Yao;X Wang;W Pang;JN Zhao;ZT Jiang;JJ Zhu;S Chien;J Zhou |
| 3 | Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility | 期刊论文 | Yue-Feng Liu;Juan-Juan Zhu;Xiao Yu Tian;Han Liu;Tao Zhang;Yun-Peng Zhang;Si-An Xie;Ming Zheng;Wei Kong;Wei-Juan Yao;Wei Pang;Chuan-Rong Zhao;Yuan-Juan Tang;Jing Zhou |
| 4 | Shear stress regulates the SNAP23-mediated endothelial secretion of VWF through the GPR68/PKA/vimentin mechanotransduction pathway | 期刊论文 | Zhitong Jiang;Juanjuan Zhu;Chuanrong Zhao;Yuanjun Tang;Han Liu;Jianan Zhao;Jianrui Zhang;Yuefeng Liu;Weijuan Yao;Lili Han;Wei Pang;Jing Zhou |
| 5 | MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1. | 期刊论文 | Tang Y;Jia Y;Fan L;Liu H;Zhou Y;Wang M;Liu Y;Zhu J;Pang W;Zhou J |
| 6 | Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1 | 期刊论文 | Yang FF;Zhang YP;Zhu JJ;Wang J;Jiang ZT;Zhao CR;Yang QR;Huang Y;Yao WJ;Pang W;Han LL;Zhou J |
| 7 | Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation | 期刊论文 | Liu H;Liu Y;Wang H;Zhao Q;Zhang T;Xie SA;Liu Y;Tang Y;Peng Q;Pang W;Yao W;Zhou J |
| 8 | VAMP3 and SNAP23 as potential targets for preventing the disturbed flow-accelerated thrombus formation | 期刊论文 | Zhu J;Jiang Z;Liu C;Xi Y;Wang J;Yang F;Yao W;Pang W;Han L;Zhang Y;Sun A;Zhou J |
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