建立大规模人群衰老的生物标记物、评价体系及数据平台
91749205
2017
C0609.生物大数据解析
韩敬东
重大研究计划
教授
北京大学
200万元
多层次网络;网络重构;系统生物学;统计模型;人
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Characterization of functional transposable element enhancers in acute myeloid leukemia | 期刊论文 | Yingying Zeng;Yaqiang Cao;Rivka Sukenik Halevy;Picard Nguyen;Denghui Liu;Xiaoli Zhang;Nadav Ahituv;Jing-Dong J. Han |
| 2 | Inter-nucleosomal communication between histone modifications for nucleosome phasing | 期刊论文 | Weizhong Chen;Yi Liu;Shanshan Zhu;Guoyu Chen;Jing-Dong J. Han |
| 3 | Repression of human and mouse brain inflammaging transcriptome by broad gene body histone hyperacetylation | 期刊论文 | Hao Cheng;Hongwen Xuan;Christopher D. Green;Yixing Han;Na Sun;Hongjie Shen;Joseph McDermott;David Bennett;Fei Lan;Jing-Dong J. Han |
| 4 | Widespread roles of enhancer-like transposable elements in cell identity and long-range genomic interactions | 期刊论文 | Yaqiang Cao;Guoyu Chen;Gang Wu;Xiaoli Zhang;Joseph McDermott;Xingwei Chen;Chi Xu;Quanlong Jiang;Zhaoxiong Chen;Yingying Zeng;Ai Daosheng;Yi Huang;Jing-Dong J. Han |
| 5 | De novo generation of macrophage from placentaderived hemogenic endothelium | 期刊论文 | Guixian Liang;Chunyu Zhou;Xiangxiang Jiang;Yifan Zhang;Baofeng Huang;Suwei Gao;Zhixin Kang;Dongyuan Ma;Fengchao Wang;Berthold Gottgens;Hongmei Wang;Jing-Dong J. Han;Feng Liu |
| 6 | Assessing the rate of aging to monitor aging itself | 期刊论文 | Xian Xia;Yiyang Wang;Zhengqing Yu;Jiawei Chen;Jing-Dong J. Han |
| 7 | The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A | 期刊论文 | Xiaoyang Dou;Jerome Boyd-Kirkup;Joseph McDermott;Xiaoli Zhang;Fang Li;Bowen Rong;Rui Zhang;Bisi Miao;eilin Chen;Hao Cheng;Jianhuang Xue;David Bennett;Jiemin Wong;Fei Lan;Jing-Dong J. Han |
| 8 | Accurate loop calling for 3D genomic data with cLoops | 期刊论文 | Yaqiang Cao;Zhaoxiong Chen;Xingwei Chen;Daosheng Ai;Guoyu Chen;Joseph McDermott;Yi Huang;Xiaoxiao Guo;Jing-Dong J Han |
| 9 | Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation | 期刊论文 | Jiawei Chen;Quanlong Jiang;Xian Xia;Kangping Liu;Zhengqing Yu;Wanyu Tao;Wenxuan Gong;Jing-Dong J. Han |
| 10 | Immune Cell Types and Secreted Factors Contributing to Inflammation-to-Cancer Transition and Immune Therapy Response | 期刊论文 | Xingwei Chen;Chi Xu;Shengjun Hong;Xian Xia;Yaqiang Cao;Joseph McDermott;Yongling Mu;Jing-Dong J. Han |
| 11 | A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis | 期刊论文 | Xue Yuanyuan;Liu Denghui;Cui Guizhong;Ding Yanyan;Ai Daosheng;Gao Suwei;Zhang Yifan;Suo Shengbao;Wang Xiaohan;Lv Peng;Zhou Chunyu;Li Yizhou;Chen Xingwei;Peng Guangdun;Jing Naihe;Han Jing Dong J;Liu Feng |
| 12 | Molecular architecture of lineage allocation and tissue organization in early mouse embryo | 期刊论文 | Guangdun Peng;Shengbao Suo;Guizhong Cui;Fang Yu;Ran Wang;Jun Chen;Shirui Chen;Zhiwen Liu;Guoyu Chen;Yun Qian;Patrick P. L;Tam;Jing-Dong J. Han;Naihe Jing |
| 13 | Aging and Alzheimer's disease: Comparison and Associations from Molecular to Systems Levels | 期刊论文 | Xian Xia;Quanlong Jiang;Joseph McDermott;Jing‐Dong J. Han |
| 14 | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups | 期刊论文 | Yanru Chen;Qiuping Huang;Ping Ai;Huamin Liu;Xueyu Chen;Xizhu Xu;Guoyong Ding;Yuejin Li;Xia Feng;Xiaohui Wang;Long Ji;Dong Li;Yong Zhou |
| 15 | Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling | 期刊论文 | Donghong Cai;Jing-Dong J. Han |
| 16 | Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes | 期刊论文 | Chi Xu;Daosheng Ai;Shengbao suo;Xingwei Chen;Yizhen Yan;Yaqiang Cao;Na Sun;Weizhong Chen;Joseph McDermott;Shiqiang Zhang;Yingying Zeng;Jing-Dong J. Han |
| 17 | Jidong cognitive impairment cohort study: objectives, design, and baseline screening | 期刊论文 | Daiyu Song;Xianwei Wang;Sa Wang;Siqi Ge;Guoyong Ding;Xueyu Chen;Yanru Chen;Huamin Liu;Xiaomei Xie;Weijia Xing;Dong Li;Yong Zhou |
| 18 | Regulatory network characterization in development: challenges and opp ortunities | 期刊论文 | Guangdun Peng;Jing-Dong J. Han |
| 19 | The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16 | 期刊论文 | Dawei Shi;Xian Xia;Aoyuan Cui;Zhongxiang Xiong;Yizhen Yan;Jing Luo;Guoyu Chen;Yingying Zeng;Donghong Cai;Lei Hou;Joseph McDermott;Yu Li;Hong Zhang;Jing-Dong J. Han |
| 20 | Effect of Body Mass Index on the Associations between Parity and Metabolic Syndrome and its Components among Northern Chinese Women | 期刊论文 | Yan Yao;Huamin Liu;Xianwei Wang;Xia Feng;Lijian Gao;Dong Li;Yong Zhou |
| 21 | Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle | 期刊论文 | Xian Xia;Xingwei Chen;Gang Wu;Fang Li;Yiyang Wang;Yang Chen;Mingxu Chen;Xinyu Wang;Weiyang Chen;Bo Xian;Weizhong Chen;Yaqiang Cao;Chi Xu;Wenxuan Gong;Guoyu Chen;Donghong Cai;Wenxin Wei;Yizhen Yan;Kangping Liu;Nan Qiao;Xiaohui Zhao;Jin Jia;Wei Wang;Brian K. Kennedy;Kang Zhang;Carlo V. Cannistraci;Yong Zhou;Jing-Dong J. Han |
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