生理平流剪切应力通过COX-2/MMPs信号通路参与机械损伤诱发骨关节炎发病的作用机制研究

31300777
2013
C1001.生物力学与生物流变学
王璞
青年科学基金项目
教授
东北大学
24万元
环氧合酶-2;平流剪切应力;骨关节炎;基质金属蛋白酶
2014-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways. 期刊论文 Guan, P-P|Huso, D L|Kontrogianni-Konstantopoulos, A|Konstantopoulos, K|
2 Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism 期刊论文 Yu Xin|Guo Jian-Jun|Konstantopoulos Konstantinos|Wang Zhan-You|
3 Prostaglandin I(2) Attenuates Prostaglandin E(2)-Stimulated Expression of Interferon gamma in a beta-Amyloid Protein- and NF-kappaB-Dependent Mechanism. 期刊论文 Yu, Xin|Zhang, Li-Chao|Su, Ya-Nan|Wang, Zhan-You|
4 Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease. 期刊论文 Wang, Pu|Wang, Zhan-You|
5 Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1alpha and anterior pharynx-defective-1beta in amyloid precursor protein/presenilin 1 transgenic mice. 期刊论文 Xu, Guo-Biao|Yu, Xin|Wang, Yue|Wang, Zhan-You|
6 By suppressing the expression of anterior pharynx-defective-1alpha and -1beta and inhibiting the aggregation of beta-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice. 期刊论文 Xu, Guo-Biao|Konstantopoulos, Konstantinos|Wang, Zhan-You|Wang, Pu|
7 Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1beta and Abeta between glial and neuron cells. 期刊论文 Wang Tao|Yu Xin|Guo Jian-Jun|Wang Zhan-You|
8 The role of cyclooxygenase-2, interleukin-1b and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage 期刊论文 Wang Tao|Konstantopoulos Konstantinos|Wang Zhan- you|Wang Pu|
9 Magnesium ion influx reduces neuroinflammation in Abeta precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1beta. 期刊论文 Wang, Yue|Zhang, Yan|Zhao, Hang|Wang, Zhan-You|
10 By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization. 期刊论文 Li, Jia-Yi|Konstantopoulos, Konstantinos|Wang, Zhan-You|Wang, Pu|
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