SUMO化修饰在急性髓系白血病发生发展中的作用及靶向研究
81630006
2016
H0809.白血病
周剑峰
重点项目
教授
华中科技大学
275万元
急性髓系白血病;血液系统恶性肿瘤;靶向治疗;分子靶点;SUMO化修饰
2017-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2 | 期刊论文 | Pan Zhou;Xing Chen;Mengke Li;Jiaqi Tan;Yicheng Zhang;Weiping Yuan;Jianfeng Zhou;Gaoxiang Wang |
| 2 | MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL | 期刊论文 | Zhou Mi;Zhou Kuangguo;Cheng Ling;Chen Xing;Wang Jue;Wang Xiao-Min;Zhang Yingchi;Yu Qilin;Zhang Shu;Wang Di;Huang Liang;Huang Mei;Ma Ding;Cheng Tao;Wang Cong-Yi;Yuan Weiping;Zhou Jianfeng |
| 3 | Development and functional characterization of novel fully human anti-CD19 chimeric antigen receptors for T-cell therapy | 期刊论文 | Dai Zhenyu;Hu Xuelian;Jia Xiangyin;Liu Jianwei;Yang Yongkun;Niu Panpan;Hu Guang;Tan Taochao;Zhou Jianfeng |
| 4 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT | 期刊论文 | Wei Jia;Xiao Min;Mao Zekai;Wang Na;Cao Yang;Xiao Yi;Meng Fankai;Sun Weimin;Wang Ying;Yang Xingcheng;Chen Liting;Zhang Yicheng;Zhu Haichuan;Zhang Shangkun;Zhang Tongcun;Zhou Jianfeng;Huang Liang |
| 5 | Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies | 期刊论文 | Xu Qian;Zhang Zheng;Zhao Lei;Qin Yun;Cai Haodong;Geng Zhe;Zhu Xiaojian;Zhang Wei;Zhang Yuanyuan;Tan Jiaqi;Wang Jue;Zhou Jianfeng |
| 6 | Osteopontin is required for the maintenance of leukemia stem cells in acute myeloid leukemia | 期刊论文 | Jing Zhou;Xing Chen;Pan Zhou;Xiaolu Sun;Yangpeng Chen;Mengke Li;Yajing Chu;Jianfeng Zhou;Xuelian Hu;Yi Luo;Weiping Yuan;Gaoxiang Wang |
| 7 | Severe early hepatitis B reactivation in a patient receiving anti-CD19 and anti-CD22 CAR T cells for the treatment of diffuse large B-cell lymphoma | 期刊论文 | Jia Wei;Xiaojian Zhu;Xia Mao;Liang Huang;Fankai Meng;Jianfeng Zhou |
| 8 | Epstein-Barr virus copy number in peripheral blood mononuclear cells predicts prognosis in diffuse large B cell lymphoma | 期刊论文 | Jing Zhou;Jin Huang;Min Xiao;Ying Wang;Wei Zhang;Jie Wan;Yi Xiao;Jianfeng Zhou |
| 9 | Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish | 期刊论文 | Tan Jiaqi;Zhao Lei;Wang Gaoxiang;Li Tongjuan;Li Dan;Xu Qian;Chen Xing;Shang Zhen;Wang Jue;Zhou Jianfeng |
| 10 | Extracellular Vesicles Expressing CD19 Antigen Improve Expansion and Efficacy of CD19-Targeted CAR-T Cells | 期刊论文 | Yuanyuan Zhang;Tong Ge;Meijuan Huang;Yun Qin;Tianjiao Liu;Wei Mu;Gaoxiang Wang;Lijun Jiang;Tongjuan Li;Lei Zhao;Jue Wang |
| 11 | Efficacy and safety of CAR19/22 T-cell cocktail therapy in patients with refractory/relapsed B-cell malignancies | 期刊论文 | Wang Na;Hu Xuelian;Cao Wenyue;Li Chunrui;Xiao Yi;Cao Yang;Gu Chaojiang;Zhang Shangkun;Chen Liting;Cheng Jiali;Wang Gaoxiang;Zhou Xiaoxi;Zheng Miao;Mao Xia;Jiang Lijun;Wang Di;Wang Qiuxiang;Lou Yaoyao;Cai Haodong;Yan Dandan;Zhang Yicheng;Zhang Tongcun;Zhou |
| 12 | Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C | 期刊论文 | Zhou Kuangguo;Zhou Mi;Cheng Ling;Chen Xing;Wang Xiaomin;Chu Yajing;Yu Qilin;Zhang Shu;Wang Na;Zhao Lei;Wang Di;Huang Liang;Wang Congyi;Yuan Weiping;Zhou Jianfeng |
| 13 | CD19/CD22 Chimeric Antigen Receptor T Cell Cocktail Therapy following Autologous Transplantation in Patients with Relapsed/Refractory Aggressive B Cell Lymphomas | 期刊论文 | Cao Yang;Xiao Yi;Wang Na;Wang Gaoxiang;Huang Liang;Hong Zhenya;Meng Li;Zhou Xiaoxi;Wang Jue;Yang Yang;Xu Hao;Zhang Shangkun;Xiao Min;Chen Liting;Zheng Miao;Li Chunrui;Mao Xia;Gu Chaojiang;Zhang Tongcun;Zhang Yicheng;Zhou Jianfeng |
| 14 | Inflammatory signatures for quick diagnosis of life-threatening infection during the CAR T-cell therapy | 期刊论文 | Hui Luo;Na Wang;Liang Huang;Xiaoxi Zhou;Jin Jin;Chunrei Li;Di Wang;Bin Xu;Jinhuan Xu;Lijun Jiang;Jue Wang;Yang Cao;Yi Xiao;Qian Zhang;Xia Mao;Songya Liu;Liting Chen;Min Xiao;Jianfeng Zhou |
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