独创的MyD88抑制剂靶向防治GVHD的新策略及机理

81471588
2014
H1105.器官移植与移植免疫
周平
面上项目
教授
华中科技大学
71万元
样受体;TJ-M2010;移植物抗宿主病;Toll;天然免疫;髓样分化因子88
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT 期刊论文 Xing S;Zhang X;Huang X;Xie L;Jiang F;Zhou P
2 Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro 期刊论文 Zhang Li-Min;Liu Jian-Hua;Xue Cheng-Biao;Li Ming-Qiang;Xing Shuai;Zhang Xue;He Wen-Tao;Jiang Feng-Chao;Lu Xia;Zhou Ping
3 Beyond knockout A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice 期刊论文 Zhang Xue;Xing Shuai;Li Mingqiang;Zhang Limin;Xie Lin;He Wentao;Liu Jianhua;Chang Sheng;Jiang Fengchao;Zhou Ping
4 Short-term Pharmacological Inhibition of MyD88 Homodimerization by a Novel Inhibitor Promotes Robust Allograft Tolerance in Mouse Cardiac and Skin Transplantation 期刊论文 Li Chao;Zhang Li-Min;Zhang Xue;Huang Xia;Liu Yong;Li Ming-Qiang;Xing Shuai;Yang Tao;Xie Lin;Jiang Feng-Chao;Jiang Han-Ying;He Wen-Tao;Zhou Ping
5 Short-term MyD88 inhibition ameliorates cardiac graft rejection and promotes donor-specific hyporesponsiveness of skin grafts in mice 期刊论文 Wen-Tao He;Li-Min Zhang;Chao Li;Shu-Yuan Li;Zuo-Chuan Ding;Ze-Min Fang;Fan-Ying Meng;Zhonghua Klaus Chen;Ping Zhou
6 Host MyD88 signaling protects against acute graft-versus-host disease after allogeneic bone marrow transplantation 期刊论文 Xing S;Zhang X;Liu JH;Huang X;Zhou P
7 MyD88抑制剂预防和治疗NOD小鼠1型糖尿病 会议论文 张学;邢帅;张利民;刘健桦;周平
8 Distinct NOD2 Polymorphism Status is Associated with Differential Outcome in Hematopoietic Stem Cell Transplantation: A Meta-Analysis 期刊论文 Shuai Xing;Lei Xing;Jian-hua Liu;Ping Zhou
9 Short-term combination treatment of FK506 and anti-CD40 ligand remarkably prolong allograft survival time in mouse skin transplantation. 会议论文 Xue Zhang;Zuochuan Ding;Min Yang;Yan Miao;Yang Yang;Ping Zhou
10 氨基噻唑类MyD88特异性抑制剂在医学上的用途 专利 周平;姜凤超
11 Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer 期刊论文 Lin Xie;Feng-Chao Jiang;Li-Min Zhang;Wen-Tao He;Jian-Hua Liu;Ming-Qiang Li;Xue Zhang;Shuai Xing;Hui Guo;Zhou Ping
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