MDM2介导的有丝分裂灾难- - -糖尿病肾病足细胞损伤的新机制

81470964
2014
H0504.继发性肾脏疾病
张春
面上项目
教授
华中科技大学
73万元
糖尿病肾病;MDM2;足细胞;有丝分裂灾难
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells 期刊论文 Meng X;Chu G;Ye C;Tang H;Qiu P;Hu Y;Li M;Zhang C
2 MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis 期刊论文 Tang H;Su H;Fan D;Ye C;Lei CT;Jiang HJ;Gao P;He FF;Zhang C
3 NADPH oxidase-induced NALP3 inflammasome activation is driven by thioredoxin-interacting protein which contributes to podocyte injury in hyperglycemia. 期刊论文 Gao P;He FF;Tang H;Lei C;Chen S;Meng X;Su H;Zhang C
4 MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway 期刊论文 Ye C;Tang H;Zhao Z;Lei CT;You CQ;Zhang J;Gao P;He FF;Chen S;Wang YM;Zhang C;Su H
5 MDM2 contributes to high glucose-induced glomerular mesangial cell proliferation and extracellular matrix accumulation via Notch1 期刊论文 Lei CT;Tang H;Ye C;You CQ;Zhang J;Zhang CY;Xiong W;Su H;Zhang C
6 The Expression and Significance of NLRP3 Inflammasome in Patients with Primary Glomerular Diseases. 期刊论文 Xiong J;Wang Y;Shao N;Gao P;Tang H;Su H;Zhang C;Meng XF
7 MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling 期刊论文 Tang H;Lei CT;Ye C;Gao P;Wan C;Chen S;He FF;Wang YM;Su H;Zhang C
8 Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B 期刊论文 Meng X;Chu G;Yang Z;Qiu P;Hu Y;Chen X;Peng W;Ye C;He F;Zhang C
9 Case report: lipid inclusion in glomerular endothelial and mesangial cells in a patient after contrast medium injection 期刊论文 Su H;Ye C;Wen Q;Zhu HY;Yi LX;Zhang C
10 Attenuation of Glomerular Endothelial Cells from High Glucose-Induced Injury by Blockade of MAD2B 期刊论文 Wang YM;Hao Y;Meng XF;He FF;Chen S;Gao P;Tang H;Su H;Zhang C
11 New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases. 期刊论文 Su H;Chen S;He FF;Wang YM;Bondzie P;Zhang C
12 Inhibition of SIRT2 alleviates fibroblast activation and renal tubulointerstitial fibrosis via MDM2 期刊论文 He FF;You RY;Ye C;Lei CT;Tang H;Su H;Zhang C
13 MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation 期刊论文 Su H;Wan Q;Tian XJ;He FF;Gao P;Tang H;Ye C;Fan D;Chen S;Wang YM;Meng XF;Zhang C
14 Lipid Deposition in Kidney Diseases: Interplay Among Redox, Lipid Mediators, and Renal Impairment 期刊论文 Su H;Wan C;Lei CT;Zhang CY;Ye C;Tang H;Qiu Y;Zhang C
15 Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update 期刊论文 Su H;Lei CT;Zhang C
16 The classic signalling and trans-signalling of interleukin-6 are both injurious in podocyte under high glucose exposure 期刊论文 Lei CT;Su H;Ye C;Tang H;Gao P;Wan C;He FF;Wang YM;Zhang C
17 MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2 期刊论文 Tang H;Fan D;Lei CT;Ye C;Gao P;Chen S;Meng XF;Su H;Zhang C
18 IL-6 increases podocyte motility via MLC-mediated focal adhesion impairment and cytoskeleton disassembly 期刊论文 He FF;Bao D;Su H;Wang YM;Lei CT;Zhang CY;Ye C;Tang H;Wan C;You CQ;Zhang J;Xiong J;Zhang C
19 Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update 期刊论文 Wan C;Su H;Zhang C
20 PKC-α Triggers EGFR Ubiquitination, Endocytosis and ERK Activation in Podocytes Stimulated with High Glucose 期刊论文 Lei CT;Wei YH;Tang H;Wen Q;Ye C;Zhang C;Su H
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