SHMT2琥珀酰化抗结直肠癌的机制研究及药物筛选
81874147
2018
H1807.肿瘤代谢
罗建沅
面上项目
教授
北京大学
58万元
SIRT5;直肠肿瘤;琥珀酰化;C08_结;丝氨酸代谢;SHMT2
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability | 期刊论文 | Yu Miao;Shi Xiaoyan;Ren Mengmeng;Liu Lu;Qi Hao;Zhang Chi;Zou Junhua;Qiu Xiaoyan;Zhu Wei-Guo;Zhang Ying E.;Wang Wengong;Luo Jianyuan |
| 2 | The deubiquitinase USP11 regulates cell proliferThe deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2ation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2 | 期刊论文 | Chunjie Meng;Jun Zhan;Delin Chen;Genze Shao;Hongquan Zhang;Wei Gu;Jianyuan Luo |
| 3 | Acetylation of p62 regulates base excision repair through interaction with APE1 | 期刊论文 | Meiting Li;Jiannan Xiong;Liqian Yang;Jie Huang;Yu Zhang;Minghui Liu;Lina Wang;Jianguo Ji;Ying Zhao;Wei-Guo Zhu;Jianyuan Luo;Haiying Wang |
| 4 | Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration | 期刊论文 | Mengmeng Ren;Xin Yang;Juntao Bie;Zhe Wang;Minghui Liu;Yutong Li;Genze Shao;Jianyuan Luo |
| 5 | MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment | 期刊论文 | Meiting Li;Boya Liu;Jingjie Yi;Yang Yang;Jiadong Wang;Wei-Guo Zhu;Jianyuan Luo |
| 6 | Acetylation of PHF5A modulates stress responses and colorectal carcinogenesis through alternative splicing mediated upregulation of KDM3A | 期刊论文 | Zhe Wang;Xin Yang;Cheng Liu;Xin Li;Buyu Zhang;Bo Wang;Yu Zhang;Chen Song;Tianzhuo Zhang;Minghui Liu;Boya Liu;Mengmeng Ren;Hongpeng Jiang;Junhua Zou;Xiaoyun Liu;Hongquan Zhang;Wei-Guo Zhu;Yuxin Yin;Zhang Zhang;Wei Gu;Jianyuan Luo |
| 7 | Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses | 期刊论文 | Lu Liu;Shuaiyi Chen;Miao Yu;Chenxu Ge;Mengmeng Ren;Boya Liu;Xin Yang;Thomas W. Christian Jr.;Ya-Ming Hou;Junhua Zou;Wei-Guo Zhu;Jianyuan Luo |
| 8 | Acetylation dependent translocation of EWSR1 regulates CHK2 alternative splicing in response to DNA damage | 期刊论文 | Tianzhuo Zhang;Zhe Wang;Minghui Liu;Lu Liu;Xin Yang;Yu Zhang;Juntao Bie;Yutong Li;Mengmeng Ren;Chen Song;Wengong Wang;Hongyu Tan;Jianyuan Luo |
| 9 | SIRT4 regulates PTEN stability through IDE in response to cellular stresses | 期刊论文 | Minghui Liu;Zhe Wang;Mengmeng Ren;Xin Yang;Boya Liu;Hao Qi;Miao Yu;Shi Song;Shuaiyi Chen;Lu Liu;Yu Zhang;Junhua Zou;Wei-Guo Zhu;Yuxin Yin;Jianyuan Luo |
| 10 | SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism | 期刊论文 | Chen Shuaiyi;Yang Xin;Yu Miao;Wang Zhe;Liu Boya;Liu Minghui;Liu Lu;Ren Mengmeng;Qi Hao;Zou Junhua;Vucenik Ivana;Zhu Wei Guo;Luo Jianyuan |
| 11 | PYCR, a key enzyme in proline metabolism, functions in tumorigenesis | 期刊论文 | Yutong Li;Juntao Bie;Chen Song;Minghui Liu;Jianyuan Luo |
| 12 | Protein post-translational modifications in the regulation of cancer hallmarks | 期刊论文 | Haiying Wang;Liqian Yang;Minghui Liu;Jianyuan Luo |
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