生物利用度屏障的双重性在调控有毒中药附子药效和毒性中的作用及分子机制

81473410
2014
H3216.中药代谢与药物动力学
刘中秋
面上项目
教授
广州中医药大学
73万元
乌头生物碱;外排转运蛋白;CYP酶;附子;生物利用度屏障
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive compounds: Implication for clinical drug-drug interactions 期刊论文 Zhang Guiyu;Ou Rilan;Li Fangyuan;Wu Jinjun;Zheng Liang;Tong Yunli;Liu Yuting;Liu Zhongqiu;Lu Linlin
2 Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots 期刊论文 Wu Peng;Gao Hui;Liu Jianxin;Liu Liang;Zhou Hua;Liu Zhongqiu
3 Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients 期刊论文 Lu Linlin;Zhou Juan;Shi Jian;Peng Xiaojuan;Qi Xiao-xiao;Wang Ying;Li Fangyuan;Zhou FuYuan;Liu Liang;Liu Zhongqiu
4 2016年第十九届新南方奖学金科研创新奖 奖励 吴锦俊
5 Toxic Markers of Matrine Determined Using H-1-NMR-Based Metabolomics in Cultured Cells In Vitro and Rats In Vivo 期刊论文 Li Zhonghuang;Zheng Liang;Shi Jian;Zhang Guiyu;Lu Linlin;Zhu Lijun;Zhang Jiajie;Liu Zhongqiu
6 岐黄中医药传承发展青年奖 奖励 刘中秋
7 2017年度广州中医药大学优秀研究生学术创新成果 奖励 张贵育
8 抑制细胞增殖与分化异常的新机制研究 奖励 刘良;沈晓燕;刘中秋;周华;梁丽娴;范星星;罗培;李婷;谢莹;萧文鸾;姜志宏;朱依谆;卢琳琳
9 Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes 期刊论文 Dai Peimin;Luo Feifei;Wang Ying;Jiang Huangyu;Wang Liping;Zhang Guiyu;Zhu Lijun;Hu Ming;Wang Xinchun;Lu Linlin;Liu Zhongqiu
10 Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in HepG2 cells 期刊论文 Wu Jinjun;Zhu Yuanfeng;Li Fangyuan;Zhang Guiyu;Shi Jian;Ou Rilan;Tong Yunli;Liu Yuting;Liu Liang;Lu Linlin;Liu Zhongqiu
11 A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine 期刊论文 Wu Jinjun;Guo Zhenzhen;Zhu Yuanfeng;Huang Zhijian;Gong Xia;Li Yuhuan;Son Wenjie;Li Xiaoyan;Lou Yanmei;Zhu Lijun;Lu Linlin;Liu Zhongqiu;Liu Liang
12 Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/beta-catenin signaling 期刊论文 Tong Yunli;Liu Yuting;Zheng Hongming;Zheng Liang;Liu Wenqin;Wu Jinjun;Ou Rilan;Zhang Guiyu;Li Fangyuan;Hu Ming;Liu Zhongqiu;Lu Linlin
13 Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic 期刊论文 Feng Shun;Zhu Lijun;Huang Zhisheng;Wang Haojia;Li Hong;Zhou Hua;Lu Linlin;Wang Ying;Liu Zhongqiu;Liu Liang
14 DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment 期刊论文 Lu Linlin;Wang Ying;Ou Rilan;Feng Qian;Ji Liyan;Zheng Hongming;Guo Yue;Qi Xiaoxiao;Ah-Ng Tony Kong;Liu Zhongqiu
15 第二十二届中国药理学会施维雅青年药理学家奖 奖励 卢琳琳
16 Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway 期刊论文 Wu Jinjun;Zhu Yuanfeng;Guo Zhenzhen;Lou Yanmei;He Shugui;Guan Yang;Zhu Lijun;Liu Zhongqiu;Lu Linlin;Liu Liang
17 Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug-drug interactions 期刊论文 Wu Jinjun;Lin Na;Li Fangyuan;Zhang Guiyu;He Shugui;Zhu Yuanfeng;Li Na;Ou Rilan;Liu Shuqiang;Feng Lizhi;Liu Liang;Liu Zhongqiu;Lu Linlin
18 Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer 期刊论文 Liu Yuting;Tong Yunli;Yang Xia;Li Fangyuan;Zheng Liang;Liu Wenqin;Wu Jinjun;Ou Rilan;Zhang Guiyu;Hu Ming;Liu Zhongqiu;Lu Linlin
19 Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC-MS/MS 期刊论文 Shi Jian;Zheng Liang;Lin Zhufen;Hou Chuqi;Liu Wenqin;Yan Tongmeng;Zhu Lijun;Wang Ying;Lu Linlin;Liu Zhongqiu
20 Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics 期刊论文 Zhu Lijun;Wu Jinjun;Zhao Min;Song Wenjie;Qi Xiaoxiao;Wang Yirig;Lu Linlin;Liu Zhongqiu
21 2017年度广州中医药大学优秀研究生学术创新成果 奖励 吴锦俊
查看更多信息请先登录或注册

相关项目

趋势报告

经验分享