以gp41为靶点的小分子艾滋病融合抑制剂的作用机制和筛选的方法学研究

81072581
2010
H3407.药物设计与药物信息
蔡利锋
面上项目
副研究员
中国人民解放军军事科学院军事医学研究院
30万元
高通量筛选;艾滋病;HIV-1;融合抑制剂;病毒-细胞融合
2011-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Design, Synthesis, and Biological Evaluation of Highly Potent Small Molecule−Peptide Conjugates as New HIV‑1 Fusion Inhibitors 期刊论文 Keliang Liu|Weiguo Shi|Lifeng Cai|Lu Lu|Qian Wang|Tianhong Zhang|Jinglai Li|Zhenqing Zhang|Liang Xu|
2 Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket 期刊论文 Keliang Liu|Huifang Xue|Kun Wang|Lifeng Cai|Jiayin Qiu|Shuangyu Bi|Luhua Lai|Maosheng Cheng|Shuwen Liu|
3 Biochemistry and Biophysics of HIV-1 gp41 – membrane interactions: Implications for HIV-1 Envelope Protein Mediated Viral-Cell Fusion and Fusion Inhibitor Design 期刊论文 Lifeng Cai|Miriam Gochin|Keliang Liu|
4 Increase of anti-HIV activity of C-peptide fusion inhibitors using a bivalent drug design approach 期刊论文 Yanbo Ling|Huifang Xue|Xifeng Jiang|Lifeng Cai|Keliang Liu|
5 Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions 期刊论文 Guiying Zhang|Kun Wang|Baohua Zheng|Maosheng Cheng|Yanni Li|Keliang Liu|Lifeng Cai|
6 HIV-1 gp41 NHR序列靶点专一性的荧光共振能转移测定 期刊论文 王昆|郑保华|蔡利锋|李燕妮|刘克良|
7 Design of highly potent HIV fusion inhibitors based on artificial peptide sequences 期刊论文 Keliang Liu|Lifeng Cai|Lu Lu|Chao Wang|Kun Wang|Liang Xu|Sha Zhang|Han Han|Xifeng Jiang|
8 Inter-chain acyl transfer reaction in a peptide six-helical bundle: a chemical method for regulating the interaction between peptides or proteins 期刊论文 Yu Bai|Huifang Xue|Yanbo Ling|Maosheng Cheng|Lifeng Cai|Keliang Liu|
9 二价HIV鄄1 融合抑制剂的设计、合成与活性评价 期刊论文 凌彦博|王昆|姜喜凤|蔡利锋|刘克良|
10 A facile surfactant Critical Micelle Concentration Determination 期刊论文 Lifeng Cai|Miriam Gochin|Keliang Liu|
11 Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination 期刊论文 Lifeng Cai|Chungen Pan|Liang Xu|Yuan Shui|Keliang Liu|Shibo Jiang|
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