新疆软紫草属植物遗传多样性、药用紫草素发掘及其应用研究
U1903201
2019
C0204.水分和营养物质的运输与代谢
杨永华
联合基金项目
教授
南京大学
256万元
软紫草属植物;药用;遗传多样性;天然产物;紫草素
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 软紫草属植物高质量基因组组装及其分析 | 会议论文 | 王煊，杨旻恺，文钟灵，马盛磷;马聿迪，金锁，揭文才，韩洪苇;林红燕，陆桂华，戚金亮;杨永华 |
| 2 | 天然紫草素抗耐甲氧西林金黄色葡萄球菌的作用机制研究 | 会议论文 | 陈庆庆，陈星雨，林发祥，何卓昱;马聿迪，金锁，韩米，杨旻恺;戚金亮，林红燕，韩洪苇;杨永华 |
| 3 | Differential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types | 期刊论文 | Aliya Fazal;Minkai Yang;Zhongling Wen;Farman Ali;Ran Ren;Chenyu Hao;Xingyu Chen;Jiangyan Fu;Xuan Wang;Wencai Jie;Tongming Yin;Guihua Lu;Jinliang Qi;Yonghua Yang |
| 4 | 一类紫草宁硫辛硫醚孪药分子及其合成方法和应用 | 专利 | 杨永华;林红燕;冯璐 |
| 5 | 一个高产乙酰紫草宁的转LeSAT1基因硬紫草毛状根株系 | 专利 | 戚金亮;杨永华;何聪;文钟灵;杨旻恺;王煊;王常怡;韩洪苇;陆桂华;林红燕;赖晓辉 |
| 6 | 天山软紫草基因组与紫草素生物合成调控研究 | 会议论文 | 王煊，杨旻恺，文钟灵，赖晓辉，揭文才，;王常怡，韩洪苇，陆桂华，戚金亮;杨永华 |
| 7 | A modified natural small molecule inhibits triple-negative breast cancer growth by interacting with Tubb3 | 期刊论文 | Hongwei Han;Minkai Yang;Zhongling Wen;Xuan Wang;Xiaohui Lai;Yahan Zhang;Rongjun Fang;Tongming Yin;Xiaorong Yang;Xiaoming Wang;Quan Zhao;Jinliang Qi;Hongyuan Chen;Hongyan Lin;Yonghua Yang |
| 8 | LeERF-1, an ethylene response factor gene from Lithospermum erythrorhizon, confers enhanced tolerance to cold and salt stresses in Arabidopsis | 期刊论文 | Hua Zhao;Rongjun Fang;Zhaoyue Wang;Aiqian Li;Shoucheng Huang;Jiangyan Fu;Zhongling Wen;Minkai Yang;Bao Liu;Guihua Lu;Runan Tian;Jinliang Qi;Yonghua Yang |
| 9 | 紫草素和乙酰紫草素缓解C. violaceum群体感应潜力的评估 | 会议论文 | Fazal Aliya，杨旻恺，王明月，法曼;文钟灵，韩洪苇，林红燕，王小明;陆桂华，戚金亮;杨永华 |
| 10 | 药用植物紫草LeTCP家族成员的鉴定及LeTCP2基因的功能研究 | 会议论文 | 赖晓辉，马盛磷，何卓昱，王常怡;王煊，杨柳，丁宇杭，Fazal Aliya，杨旻恺;韩洪苇，文钟灵，陆桂华，戚金亮;杨永华 |
| 11 | Genome-Wide Identification of LeBAHDs in Lithospermum erythrorhizon and In Vivo Transgenic Studies Confirm the Critical Roles of LeBAHD1/LeSAT1 in the Conversion of Shikonin to Acetylshikonin | 期刊论文 | Xuan Wang;Zhuoyu He;Huan Yang;Cong He;Changyi Wang;Aliya Fazal;Xiaohui Lai;Liangjie Yang;Zhongling Wen;Minkai Yang;Shenglin Ma;Wencai Jie;Jinfeng Cai;Tongming Yin;Bao Liu;Yonghua Yang;Jinliang Qi |
| 12 | 紫草素及其衍生物对溃疡性结肠炎炎症及黏膜屏障损伤的差异缓解作用 | 会议论文 | 韩洪苇，孙文学，冯璐，文钟灵;杨旻恺，马迎迎，傅江燕，马筱芃;徐欣宏，王昭月，王小明，陆桂华，戚金亮，林红燕;杨永华 |
| 13 | 天然紫草素类化合物抗真菌生物活性评价及其作用机制研究 | 会议论文 | 陈庆庆，胡佳宝，马聿迪，穆欣荣;孙雨倩，赖晓辉，文钟灵，杨旻恺;陆桂华，戚金亮，杨荣武;林红燕，韩洪苇;杨永华 |
| 14 | Establishment of the hairy root culture of Echium plantagineum L. and its shikonin production | 期刊论文 | Jiang-Yan Fu;Hua Zhao;Jia-Xin Bao;Zhong-Ling Wen;Rong-Jun Fang;Aliya Fazal;Min-Kai Yang;Bao Liu;Tong-Ming Yin;Yan-Jun Pang;Gui-Hua Lu;Jin-Liang Qi;Yong-Hua Yang |
| 15 | Anti‐microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids | 期刊论文 | Hongyan Lin;Jiabao Hu;Feng Mei;Yahan Zhang;Yudi Ma;Qingqing Chen;Changyi Wang;Jiangyan Fu;Minkai Yang;Zhongling Wen;Xiaoming Wang;Jinliang Qi;Hongwei Han;Rongwu Yang;Yonghua Yang |
| 16 | 紫草素及其衍生物抗结直肠癌生物活性和作用机制研究 | 会议论文 | 胡佳宝，马筱芃，梅峰，陈庆庆;马聿迪，罗富河，何卓昱，赖晓辉;林红燕，戚金亮，韩洪苇;杨永华 |
| 17 | 一种化合物在制备抗真菌药物中的应用 | 专利 | 杨永华;林红燕、胡佳宝、文钟灵;韩洪苇、戚金亮、周紫玲;马筱芃、任然、梅峰 |
| 18 | 靶向AKT变构位点的新型紫草素改构物分子的设计、合成和生物活性研究 | 会议论文 | 马聿迪，林发祥，陈庆庆，赖晓辉，杨旻恺;文钟灵，戚金亮，韩洪苇，林红燕，陆桂华;杨永华 |
| 19 | 紫草素-中药植物天然产物:生物合成、遗传调控、结构修饰与医药功能 | 期刊论文 | 王煊;杨旻恺;韩洪苇;文钟灵;陆桂华;戚金亮;林红燕;杨永华 |
| 20 | Overexpression of a putative 12-oxophytodienoate reductase gene, EpOPR1, enhances acetylshikonin production in Echium plantagineum | 期刊论文 | Jiangyan Fu;Ran Ren;Suo Jin;Rongjun Fang;Zhongling Wen;Minkai Yang;Xuan Wang;Bao Liu;Tongming Yin;Guihua Lu;Yonghua Yang;Jinliang Qi |
| 21 | Novel shikonin derivative suppresses tumor growth and metastasis intervention of Wnt/β-catenin pathway | 期刊论文 | Hongwei Han;Zhongling Wen;Xiaohui Lai;Minkai Yang;Jiangyan Fu;Liangjie Yang;Qingqing Chen;Yudi Ma;Wencai Jie;Changyi Wang;Tongming Yin;Guihua Lu;Xiaoming Wang;Shucun Sun;Quan Zhao;Jinliang Qi;Hongyan Lin;Yonghua Yang |
| 22 | 硬紫草LeBAHD家族基因鉴定及LeBAHD1调控乙酰紫草宁合成的功能研究 | 会议论文 | 王常怡，何聪，王煊，杨欢;付婷，杨柳，杨旻恺，文钟灵;韩洪苇，林红燕，陆桂华，戚金亮;杨永华 |
| 23 | 紫草LeBAHD56基因克隆及其调控乙酰紫草宁合成的功能研究 | 会议论文 | 杨柳，杨欢，金锁，王煊;王常怡，赖晓辉，Fazal Aliya，杨旻恺;韩洪苇，文钟灵，陆桂华，戚金亮;杨永华 |
| 24 | 车前叶蓝蓟EpBAHD家族基因鉴定及EpBAHD12的表达调控研究 | 会议论文 | 王常怡，付婷，杨欢，王煊，杨柳;赖晓辉，厉中义，揭文才，杨旻恺;文钟灵，韩洪苇，陆桂华，戚金亮;杨永华 |
| 25 | Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines | 期刊论文 | Hongwei Han;Cong He;Xingyu Chen;Yuelin Luo;Minkai Yang;Zhongling Wen;Jiabao Hu;Faxiang Lin;Mi Han;Tongming Yin;Rongwu Yang;Hongyan Lin;Jinliang Qi;Yonghua Yang |
| 26 | 一种化合物在制备抗耐甲氧西林金黄色葡萄球菌中的应用 | 专利 | 杨永华;韩洪苇、陈星雨、林红燕;戚金亮、杨旻恺、陈庆庆;马聿迪、郝晨宇 |
| 27 | 新型紫草宁硫辛硫醚衍生物靶向PDK1抗乳腺癌研究 | 会议论文 | 冯璐，周紫玲，林发祥，王煊;胡佳宝，揭文才，李登超，韩洪苇，林红燕;杨永华 |
| 28 | 天山软紫草基因组与紫草素生物合成调控研究 | 会议论文 | 王煊，杨旻恺，文钟灵，赖晓辉，揭文才;王常怡，韩洪苇，林红燕，陆桂华，戚金亮、;杨永华 |
| 29 | Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment | 期刊论文 | Yudi Ma;Xiaohui Lai;Zhongling Wen;Ziling Zhou;Minkai Yang;Qingqing Chen;Xuan Wang;Feng Mei;Liu Yang;Tongming Yin;Shucun Sun;Guihua Lu;Jinliang Qi;Hongyan Lin;Hongwei Han;Yonghua Yang |
| 30 | Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis | 期刊论文 | Hongwei Han;Wenxue Sun;Lu Feng;Zhongling Wen;Minkai Yang;Yingying Ma;Jiangyan Fu;Xiaopeng Ma;Xinhong Xu;Zhaoyue Wang;Tongming Yin;Xiao-Ming Wang;Gui-Hua Lu;Jin-Liang Qi;Hongyan Lin;Yonghua Yang |
| 31 | Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis | 期刊论文 | Qingqing Chen;Hongwei Han;Faxiang Lin;Liangjie Yang;Lu Feng;Xiaohui Lai;Zhongling Wen;Minkai Yang;Changyi Wang;Yudi Ma;Tongming Yin;Guihua Lu;Hongyan Lin;Jinliang Qi;Yonghua Yang |
| 32 | Cloning and functional analysis of EpGHQH1 in shikonin production of Echium plantagineum | 期刊论文 | Jiangyan Fu;Guihua Lu;Minkai Yang;Hua Zhao;Wencai Jie;Aliya Fazal;Xuan Wang;Zhongling Wen;Rongjun Fang;Bao Liu;Tongming Yin;Jinliang Qi;Yonghua Yang |
| 33 | 苯磺酰紫草宁类衍生物及其合成方法和应用 | 专利 | 杨永华;杨旻恺、马聿迪、韩洪苇;周紫玲、文钟灵、林红燕;陈庆庆、戚金亮、陆桂华 |
| 34 | 双靶点抗结直肠癌的紫草宁改构物设计合成及其对动物模型的药理作用研究 | 会议论文 | 马聿迪，周紫玲，王煊，王常怡;赖晓辉，胡佳宝，姚玮璇，文钟灵;戚金亮，韩洪苇，林红燕;杨永华 |
| 35 | 紫草HMGR基因家族全基因组分析及其对次生代谢生物合成影响的功能研究 | 会议论文 | 王煊，王常怡，揭文才，何卓昱;赖晓辉，杨柳，陈庆庆，韩洪苇;文钟灵，杨旻恺，陆桂华，戚金亮;杨永华 |
| 36 | 靶向PI3K/Akt/mTOR信号通路的苯胺类(二羧酸)紫草素酯抗肿瘤药物的设计、合成及生物学评价 | 会议论文 | 马迎迎，韩洪苇，文钟灵，杨旻恺;张雅涵，傅江燕，王煊，陆桂华;戚金亮，林红燕，王小明;杨永华 |
| 37 | Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway | 期刊论文 | Yingying Ma;Xiaorong Yang;Hongwei Han;Zhongling Wen;Minkai Yang;Yahan Zhang;Jiangyan Fu;Xuan Wang;Tongming Yin;Guihua Lu;Jinliang Qi;Hongyan Lin;Xiaoming Wang;Yonghua Yang |
| 38 | 中药植物紫草天然产物的生物合成及其功能研究进展 | 期刊论文 | 林红燕;王煊;何聪;周紫玲;杨旻恺;文钟灵;韩洪苇;陆桂华;戚金亮;杨永华 |
| 39 | 一种紫草宁衍生物抗新型冠状病毒的应用 | 专利 | 杨永华;韩洪苇、戚金亮、杨旻恺;文钟灵、林红燕、陆桂华 |
| 40 | 两种不同土壤类型中紫草素产生植物根际细菌群落的差异组合 | 会议论文 | Fazal Aliya，杨旻恺，文钟灵，法曼;任然，郝晨宇，陈星雨，傅江燕;王煊，揭文才，陆桂华，戚金亮;杨永华 |
| 41 | Uncover the differentially expressed miRNAs in response to light signals in Lithospermum erythrorhizon | 期刊论文 | Hua Zhao;Rongjun Fang;Shoucheng Huang;Zhongling Wen;Minkai Yang;Hu Zhao;Bao Liu;Tongming Yin;Guihua Lu;Jinliang Qi;Yonghua Yang |
| 42 | Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer. | 期刊论文 | Hongyan Lin;Xiaopeng Ma;Xiaorong Yang;Qingqing Chen;Zhongling Wen;Minkai Yang;Jiangyan Fu;Tongming Yin;Guihua Lu;Jinliang Qi;Hongwei Han;Yonghua Yang |
| 43 | Genome-wide comparison and functional characterization of HMGR gene family associated with shikonin biosynthesis in Lithospermum erythrorhizon | 期刊论文 | Xuan Wang;Changyi Wang;Minkai Yang;Wencai Jie;Aliya Fazal;Jiangyan Fu;Tongming Yin;Jinfeng Cai;Bao Liu;Guihua Lu;Hongyan Lin;Hongwei Han;Zhongling Wen;Jinliang Qi;Yonghua Yang |
| 44 | 靶向AKT的新型紫草宁衍生物与曲美替尼联用抗三阴性乳腺癌药理作用研究 | 会议论文 | 韩洪苇，梅峰，陈庆庆，马聿迪;吕晓然，涂情情，Fazal Aliya，杨旻恺;陆桂华，文钟灵，戚金亮，林红燕;杨永华 |
| 45 | Assessment of shikonin and acetyl-shikonin for mitigating quorum sensing potential of C. violaceum | 期刊论文 | Aliya Fazal;Minkai Yang;Mingyue Wang;Farman Ali;Zhongling Wen;Tongming Yin;Xiangxiang Zhao;Xiaomei Hua;Hongwei Han;Hongyan Lin;Xiaoming Wang;Guihua Lu;Jinliang Qi;Yonghua Yang |
| 46 | PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism | 期刊论文 | Hongyan Lin;Hongwei Han;Minkai Yang;Zhongling Wen;Qingqing Chen;Yudi Ma;Xuan Wang;Changyi Wang;Tongming Yin;Xiaoming Wang;Guihua Lu;Hongyuan Chen;Jinliang Qi;Yonghua Yang |
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