血液外泌体miRNA通过调节线粒体功能介导神经退行性变化的作用及机制研究
92049109
2020
C0705.细胞衰老、死亡及自噬
王延博
重大研究计划
研究员
南京大学
60万元
神经退行性变化;线粒体;外泌体miRNA;非编码RNA (ncRNA)
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | microRNAs in aged sperm confer psychiatric symptoms to offspring through causing the dysfunction of estradiol signaling in early embryos | 期刊论文 | Gaoli Liang;Xiaoju Zhu;Zixuan Zhang;Li Chen;Huijin Feng;Shoubin Zhan;Huanhuan Hu;Ranran Yu;Chen-Yu Zhang;Zhichun Feng;Bing Yao;Yanbo Wang;Xi Chen |
| 2 | 小分子抑制剂在制备用于治疗/缓解抑郁症的药物中的应用 | 专利 | 王延博;朱晓菊;丁子妍;凌欣怡 |
| 3 | 中国青年创新创业大赛 金奖 | 奖励 | 王延博;詹守斌;胡欢欢;周圣凯 |
| 4 | Small extracellular vesicles derived from young plasma rejuvenate whole body physiology in aged mice by stimulating PGC-1a expression and improving mitochondrial energy metabolism. | 期刊论文 | Chen Xiaorui;Luo Yang;Zhu Qing;Zhang Jingzi;Huang Huan;Kan Yansheng;Li Dian;Xu Ming;Liu Shuohan;Li Jianxiao;Pan Jinmeng;Zhang Li;Guo Yan;Wang Binghao;Qi Guantong;Zhou Zhen;Zhang Chen-Yu;Fang Lei;Wang Yanbo;Chen Xi |
| 5 | Sperm microRNAs confer depression susceptibility to offspring | 期刊论文 | Wang Yanbo;Chen Zhang-Peng;Hu Huanhuan;Lei Jieqiong;Zhou Zhen;Yao Bing;Chen Li;Liang Gaoli;Zhan Shoubin;Zhu Xiaoju;Jin Fangfang;Ma Rujun;Zhang Jun;Liang Hongwei;Xing Ming;Chen Xiao-Rui;Zhang Chen-Yu;Zhu Jing-Ning;Chen Xi |
| 6 | 江苏省“333高层次人才培养工程” | 奖励 | 王延博 |
| 7 | 一种用于筛查、诊断早期多种癌种的生物标志物及其应用 | 专利 | 王延博;金芳芳 |
| 8 | “强国青年科学家”提名 | 奖励 | 王延博 |
| 9 | A novel class of tsRNA signatures as biomarkers for diagnosis and prognosis of pancreatic cancer | 期刊论文 | Jin Fangfang;Yang Liuqing;Wang Weixiang;Yuan Na;Zhan Shoubin;Yang Ping;Chen Xi;Ma Tonghui;Wang Yanbo |
| 10 | Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients | 期刊论文 | Wang Yanbo;Zhu Xiaoju;Jiang Xia-Ming;Guo Jingwei;Fu Zheng;Zhou Zhen;Yang Ping;Guo Hongyuan;Guo Xu;Liang Gaoli;Zeng Ping;Xiao Gengfu;Ma Jizheng;Yin Xin;Zhang Lei-Ke;Yan Chao;Zhang Chen-Yu |
| 11 | A Novel Serum tsRNA for Diagnosis and Prediction of Nephritis in SLE | 期刊论文 | Yang Ping;Zhang Xiaoshan;Chen Shanshan;Tao Yue;Ning Mingzhe;Zhu Yijia;Liang Jun;Kong Wei;Shi Bo;Li Zhiyang;Shen Han;Wang Yanbo |
| 12 | Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis | 期刊论文 | Zhan Shoubin;Yang Ping;Zhou Shengkai;Xu Ye;Xu Rui;Liang Gaoli;Zhang Chenyu;Chen Xi;Yang Liuqing;Jin Fangfang;Wang Yanbo |
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