化合物8a靶向TBC1D15-GBP5信号轴抑制NLRP3炎症小体活化的机制及其对炎症性疾病的作用
81903620
2019
H3504.抗炎与免疫药物药理
刘雯
青年科学基金项目
研究员
南京大学
21万元
GBP5;炎症相关疾病;小分子化合物;NLRP3炎症小体;TBC1D15
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice | 期刊论文 | Liu Wen;Wang Meijing;Shen Lihong;Zhu Yuyu;Ma Hongyue;Liu Bo;Ouyang Liang;Guo Wenjie;Xu Qiang;Sun Yang |
| 2 | Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1 | 期刊论文 | Ji Geng;Wen Liu;Jian Gao;Chunhong Jiang;Ting Fan;Yang Sun;Zheng‐Hong Qin;Qiang Xu;Wenjie Guo;Jing Gao |
| 3 | Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice | 期刊论文 | Jian Cui;Jian Gao;Yan Li;Ting Fan;Jiao Qu;Yang Sun;Wen Liu;Wenjie Guo;Qiang Xu |
| 4 | Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis | 期刊论文 | Jianhua Gao;Jian Cui;Haiqing Zhong;Yan Li;Wen Liu;Chenyang Jiao;Jian Gao;Chunhong Jiang;Wenjie Guo;Qiang Xu |
| 5 | NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling | 期刊论文 | Wu Tiancong;Gao Jianhua;Liu Wen;Cui Jian;Yang Miaofang;Guo Wenjie;Wang Fang-Yu |
| 6 | Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release | 期刊论文 | Liu Wen;Fan Ting;Li Manru;Zhang Guohui;Guo Wenjie;Yang Xiaoling;Jiang Chunhong;Li Xiang;Xu Xiangyu;Tang Anshu;Liu Keqin;Liu Lixuan;Kong Lingdong;Xu Qiang;Sun Yang |
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