能量代谢在肌萎缩侧索硬化发病中的作用及分子机制

31171048
2011
C0904.感觉与运动系统神经生物学
邓敏
面上项目
研究员
北京大学
55万元
线粒体;能量代谢;ALS;AMPK;Sirt1
2012-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 家族性肌萎缩侧索硬化遗传病因学与相关临床表型研究进展 期刊论文 邓敏|
2 INHIBITION OF Sirt1 FUNCTIONS PROMOTES NEURAL PROGENITORS TOWARDS MOTORNEURON DIFFERENTIATION FROM HUMAN EMBRYONIC STEM CELLS 会议论文
3 Induced Pluripotent Stem Cells from ALS Patients 会议论文
4 The Geneitics of ALS in China.  会议论文
5 Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells. 期刊论文 Min Deng|
6 Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis 期刊论文 Yang, Sen|Ju, Xiaodong|Wang, Kai|Zhang, Xuejun|
7 Generation integration-free and Xeno-free induced pluripotent stem cells from blood cells of fALS patient carrying FUS gene mutation 会议论文
8 全基因组关联分析研究发现中国汉族人群肌萎缩侧索硬化两个易患位点 期刊论文 邓敏|
9 ALS遗传病因学及发病机制研究进展 会议论文 邓敏|
10 诱导性多潜能干细胞在神经系统变性疾病中的研究进展 期刊论文 刘新秀|邓敏|
11 The fused in sarcoma protein forms cytoplasmic aggregates in motorneurons derived from integration-free induced pluripotent stem cells generatedfrom a patient with familial amyotrophic lateral sclerosis carrying theFUS-P525L mutation. 期刊论文 李小刚|陈琪|高绍荣|邓敏|
12 Twodistinct clinical features and cognitive impairment in amyotrophic lateralsclerosis patients with TARDBP gene mutations in the Chinese population. 期刊论文 刘娜|张楠|刘涛|邓敏|
13 Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. 期刊论文 Min Deng|
14 Single-nucleotide Polymorphism rs2275294 in ZNF512B is not Associated with Susceptibility to Amyotrophic Lateral Sclerosis in a Large Chinese Cohort. 期刊论文 陈静|李小刚|刘文超|邓敏|
15 Protective Effects of Resveratrol on the Mutant hSOD1G93A-Bearing Motor Neuron-like Cell Culture Model of Amyotrophic Lateral Sclerosis through the upregulation of SIRT1 expression 会议论文 Yun Zhang|Lu Tang|Nan Zhang|Dong Sheng Fan|
16 TARDBP gene mutations in Chinese patients with familial amyotrophic lateral sclerosis 会议论文 Min Deng|
17 The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes 期刊论文 Wang, Jian-quan|Yu, Jia-kuo|Cui, Guo-qing|Hu, Yue-lin|
18 Protective Effect of Sinomenine on Cartilage Degradation and Chondrocytes Apoptosis 期刊论文 Wang, Jian-quan|Yu, Jia-kuo|Cui, Guo-qing|Hu, Yue-lin|
19 REPLICATION ANALYSIS OF SNPs ON 9p21.2 AND 19p13.3 WITH AMYOTROPHIC LATERAL SCLEROSIS IN CHINESE 会议论文
20 肌萎缩侧索硬化患者认知改变的临床研究 会议论文
21 肌萎缩侧索硬化代谢异常的研究进展 期刊论文 王晶|邓敏|樊东升|
22 Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. 会议论文
23 诱导多潜能性干细胞在神经系统变性疾病中的研究进展 期刊论文 刘新秀|邓敏|
24 Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in Chinese 会议论文 Min Deng|
25 The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes. 期刊论文 邓敏|
26 .Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis. 期刊论文 邓敏|
27 Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis (vol 45, pg 697, 2013) 期刊论文 Yang, Sen|Ju, Xiaodong|Wang, Kai|Zhang, Xuejun|
28 SOD1-V14M基因突变的肌萎缩侧索硬化患者特异的诱导性多能干细胞系的建立 期刊论文 陈嘉瑜|李小刚|高绍荣|邓敏|
29 Generation of induced pluripotent stem cells from ALS patients with different mutations. 会议论文
30 Clinicaland Genetic Analysis of Familial ALS in China 会议论文
31 TARDBP gene mutations in Chinese patients with familial amyotrophic lateral sclerosis. 会议论文 Jing Wang|Nan Zhang|Lu Tang|Dong Sheng Fan|
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