剪接因子prpf31功能及其突变引起视网膜色素变性和眼发育异常的分子机制
31871260
2018
C0604.表型、行为与疾病的遗传学基础
刘木根
面上项目
教授
华中科技大学
60万元
动物模型;世界人群;视网膜色素变性;遗传疾病;疾病机制
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. | 期刊论文 | Lu Z;Hu X;Reilly J;Jia D;Liu F;Yu S;Liu X;Xie S;Qu Z;Qin Y;Huang Y;Lv Y;Li J;Gao P;Wong F;Shu X;Tang Z;Liu M |
| 2 | Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. | 期刊论文 | Liu F;Qin Y;Huang Y;Gao P;Li J;Yu S;Jia D;Chen X;Lv Y;Tu J;Sun K;Han Y;Reilly J;Shu X;Lu Q;Tang Z;Xu C;Luo D;Liu M |
| 3 | Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. | 期刊论文 | Gao P;Jia D;Li P;Huang Y;Hu H;Sun K;Lv Y;Chen X;Han Y;Zhang Z;Ren X;Wang Q;Liu F;Tang Z;Liu M |
| 4 | Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish | 期刊论文 | Jia D;Gao P;Lv Y;Huang Y;Reilly J;Sun K;Han Y;Hu H;Chen X;Zhang Z;Li P;Luo J;Shu X;Tang Z;Liu F;Liu M;Ren X |
| 5 | The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells | 期刊论文 | Tu Jiayi;Liu Xiliang;Jia Haibo;Reilly James;Yu Shanshan;Cai Chen;Liu Fei;Lv Yuexia;Huang Yuwen;Lu Zhaojing;Han Shanshan;Jiang Tao;Shu Xinhua;Wu Xiaoyan;Tang Zhaohui;Lu Qunwei;Liu Mugen |
| 6 | A large deletion spanning PITX2 and PANCR in a Chinese family with Axenfeld-Rieger syndrome. | 期刊论文 | Qin Y;Gao P;Yu S;Li J;Huang Y;Jia D;Tang Z;Li P;Liu F;Liu M |
| 7 | Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing | 期刊论文 | Jingzhen Li;Fei Liu;Yuexia Lv;Kui Sun;Yuntong Zhao;Jamas Reilly;Yangjun Zhang;Jiayi Tu;Shanshan Yu;Xiliang Liu;Yayun Qin;Yuwen Huang;Pan Gao;Danna Jia;Xiang Chen;Yunqiao Han;Xinhua Shu;Daji Luo;Zhaohui Tang;Mugen Liu |
| 8 | Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish. | 期刊论文 | Xie S;Han S;Qu Z;Liu F;Li J;Yu S;Reilly J;Tu J;Liu X;Lu Z;Hu X;Yimer TA;Qin Y;Huang Y;Lv Y;Jiang T;Shu X;Tang Z;Jia H;Wong F;Liu M |
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