RP2突变导致其蛋白水平降低并引起视网膜色素变性的机制研究
31601026
2016
C0604.表型、行为与疾病的遗传学基础
刘飞
青年科学基金项目
博士后
华中科技大学
21万元
蛋白降解途径;斑马鱼;翻译后修饰;视网膜变性;RP2
2017-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking | 期刊论文 | Qu Zhen;Yimer Tinsae Assefa;Xie Shanglun;Wong Fulton;Yu Shanshan;Liu Xiliang;Han Shanshan;Ma Juanjuan;Lu Zhaojing;Hu Xuebin;Qin Yayun;Huang Yuwen;Lv Yuexia;Li Jingzhen;Tang Zhaohui;Liu Fei;Liu Mugen |
| 2 | CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. | 期刊论文 | Yu Shanshan;Li Chang;Biswas Lincoln;Hu Xuebin;Liu Fei;Reilly James;Liu Xiliang;Liu Ying;Huang Yuwen;Lu Zhaojing;Han Shanshan;Wang Lei;Yu Liu Jing;Jiang Tao;Shu Xinhua;Wong Fulton;Tang Zhaohui;Liu Mugen |
| 3 | Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. | 期刊论文 | Liu Fei;Qin Yayun;Yu Shanshan;Soares Dinesh C;Yang Lifang;Weng Jun;Li Chang;Gao Meng;Lu Zhaojing;Hu Xuebin;Liu Xiliang;Jiang Tao;Liu Jing Yu;Shu Xinhua;Tang Zhaohui;Liu Mugen |
| 4 | Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. | 期刊论文 | Lu Zhaojing;Hu Xuebin;Liu Fei;Soares Dinesh C;Liu Xiliang;Yu Shanshan;Gao Meng;Han Shanshan;Qin Yayun;Li Chang;Jiang Tao;Luo Daji;Guo An-Yuan;Tang Zhaohui;Liu Mugen |
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