蛋白酶体/分子伴侣活性与错叠蛋白累积的关系及其在多聚谷氨酰胺神经退行性疾病中的作用

30430260
2004
H0904.运动障碍性疾病
李和
重点项目
教授
华中科技大学
135万元
亨廷顿蛋白;错误;分子伴侣;泛素-蛋白酶体系统;多聚谷氨酰胺病
2005-01-01到2009-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 胰岛素抑制突变亨廷顿蛋白的聚积和毒性 期刊论文 叶翠芳|何小波|邹玮|李和|刘思|
2 Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice 期刊论文 Chesselet, MF|Li, H|Sison, JD|Zeitlin, S|Olivieri, M|Li, XJ|Wu, Y|Menalled, LB|
3 Endoplasmic reticulum stress and cellular toxicity of mutant huntingtin 会议论文 Yinong Zhang|He Li|Weixi Wang|Huiping Tan|Yufeng Jiang|
4 武汉地区CAG扩增突变致青少年发病的亨廷顿舞蹈病的家系分析(英文) 期刊论文 刘媛|王慧|李和|沈滟|唐艳平|陈燕|杨真荣|
5 Selective Expression of Huntingtin-associated Protein 1 in beta-Cells of the Rat Pancreatic Islets 期刊论文 Li, He|Han, Jinhong|Chen, Xingxing|Peng, Ting|Liao, Min|Yang, Shiming|
6 CD56(+) T Cells Inhibit Hepatitis C Virus Replication in Human Hepatocytes 期刊论文 Zhou, Lin|Wang, Xu|Wang, Yanjian|Hou, Wei|Wang, Shihong|Ye, Li|Song, Li|Li, He|Ho, Wenzhe|
7 Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease 期刊论文 Ghazi-Noori, S|Li, XJ|Sharpe, PT|Bates, GP|Li, H|Faruque, SMNN|Benn, CL|Woodman, B|Cha, JHJ|Olson, JM|Sathasivam, K|Hockly, E|Li, SH|Strand, AD|Landles, C|
8 蛋白酶体活性与突变亨廷顿蛋白聚集物累积及其细胞毒性的关系 会议论文 黄珊珊|张亦农|贺军|章宏峰|李和|
9 Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release 期刊论文 Yu, ZX|Li, SH|Li, XJ|Wyman, T|Li, H|
10 R6/2型亨廷顿病转基因小鼠胰岛β细胞功能损伤 期刊论文 李和|叶翠芳|
11 ACTIVATION OF TOLL-LIKE RECEPTOR-3 INDUCES INTERFERON-lambda EXPRESSION IN HUMAN NEURONAL CELLS 期刊论文 Wang, X.|Ho, W. Z.|Hou, W.|Wang, Y. J.|Ye, L.|Li, H.|Hu, S.|Zhou, Y.|Zhou, L.|
12 动态检测活细胞内泛素-蛋白酶体系统活性方法的建立 期刊论文 李和|张亦农|章宏峰|贺军|汪薇曦|
13 武汉地区CAG扩增突变致青少年发病的亨廷顿舞蹈病的家系分析(英文) 期刊论文 刘媛|王慧|李和|沈滟|唐艳平|陈燕|杨真荣|
14 N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking 期刊论文 Li, He|Wang, Jianjun|Li, Xiao-Jiang|Mastroberardino, Pier Giorgio|Wang, Chuan-En|Xu, Xingshun|Li, Shihua|Rong, Juan|Orr, Adam L.|Greenamyre, J. Timothy|
15 RNA-mediated pathogenesis in fragile X-associated disorders 期刊论文 Tan, Huiping|Li, He|Jin, Peng|
16 Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat 期刊论文 Li, XJ|Liao, M|Shen, JY|Li, H|Zhang, Y|Li, SH|
17 胞浆内非聚集型突变亨廷顿蛋白影响神经细胞的分化 期刊论文 张亦农|李和|叶翠芳|汪薇曦|
18 Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice 期刊论文 Mangiarini, L|Li, XJ|Li, SH|Bates, GP|Cheng, AL|Li, H|
19 R6/2型亨廷顿病转基因小鼠胰岛β细胞功能损伤 期刊论文 叶翠芳|李和|
20 Inhibition of neurite outgrowth and promotion of cell death by cytoplasmic soluble mutant huntingtin stably transfected in mouse neuroblastoma cells 期刊论文 Wang, Jianzhi|Ye, Cuifang|Zhang, Yinong|Li, He|Wang, Weixi|
21 突变亨廷顿蛋白可通过内质网应激引起细胞毒性 会议论文 姜玉峰|张亦农|谈慧平|汪薇曦|李和|
22 Endoplasmic reticulum stress and cellular toxicity of mutant huntingtin 会议论文 Yinong Zhang|He Li|Weixi Wang|Huiping Tan|Yufeng Jiang|
23 Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases 期刊论文 Li, Xiang|Li, He|Li, Xiao-Jiang|
24 胞浆内非聚集型突变亨廷顿蛋白影响神经细胞的分化 期刊论文 张亦农|李和|叶翠芳|汪薇曦|
25 胰岛素抑制突变亨廷顿蛋白的聚积和毒性 期刊论文 叶翠芳|何小波|邹玮|李和|刘思|
26 动态检测活细胞内泛素-蛋白酶体系统活性方法的建立 期刊论文 李和|张亦农|章宏峰|贺军|汪薇曦|
27 Selective Expression of Huntingtin-associated Protein 1 in beta-Cells of the Rat Pancreatic Islets 期刊论文 Han, Jinhong|Peng, Ting|Chen, Xingxing|Li, He|Yang, Shiming|Liao, Min|
28 Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases 期刊论文 Li, Xiao-Jiang|Li, Xiang|Li, He|
29 Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments 期刊论文 Wang, Chuan-En|Li, Shihua|Li, Xiang|Huang, Shanshan|Xu, Xingshun|Li, He|Li, Xiao-Jiang|
30 Inhibition of neurite outgrowth and promotion of cell death by cytoplasmic soluble mutant huntingtin stably transfected in mouse neuroblastoma cells 期刊论文 Wang, Weixi|Wang, Jianzhi|Ye, Cuifang|Li, He|Zhang, Yinong|
31 大鼠视网膜中HAP1的免疫组织化学定位及不同光照条件对HAP1表达的影响 期刊论文 汪薇曦|李和|黄珊珊|张亦农|
32 Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity 期刊论文 Johnston, H|Li, SH|Li, XJ|Li, H|Shelbourne, PF|
33 Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice 期刊论文 Li, H|Li, XJ|Li, SH|Shebourne, P|Yu, ZX|
34 Interaction of Huntington disease protein with transcriptional activator Sp1 期刊论文 Li, XJ|Zhou, H|Li, SH|Rao, M|Li, H|Cheng, AL|Lam, S|
35 热休克蛋白水平与突变亨廷顿蛋白聚积和毒性的关系研究 会议论文 章宏峰|张亦农|汪薇曦|李和|黄珊珊|叶翠芳|
36 热休克蛋白40和热休克蛋白70抑制N2a细胞内突变亨廷顿蛋白聚集和毒性 期刊论文 叶翠芳|李和|
37 蛋白酶体活性与突变亨廷顿蛋白聚集物累积及其细胞毒性的关系 会议论文 黄珊珊|张亦农|贺军|章宏峰|李和|
38 Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease 期刊论文 Li, XJ|Pillarisetti, A|Li, H|Evans, J|Yu, ZX|Li, SH|
39 HSP40 Ameliorates Impairment of Insulin Secretion by Inhibiting Huntingtin Aggregation in a HD Pancreatic beta Cell Model 期刊论文 Li, He|Ye, Cui-Fang|
40 热休克蛋白水平与突变亨廷顿蛋白聚积和毒性的关系研究 会议论文 章宏峰|张亦农|汪薇曦|李和|黄珊珊|叶翠芳|
41 N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking 期刊论文 Wang, Jianjun|Wang, Chuan-En|Rong, Juan|Li, Xiao-Jiang|Mastroberardino, Pier Giorgio|Xu, Xingshun|Li, He|Li, Shihua|Greenamyre, J. Timothy|Orr, Adam L.|
42 突变亨廷顿蛋白可通过内质网应激引起细胞毒性 会议论文 姜玉峰|张亦农|谈慧平|汪薇曦|李和|
43 Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease 期刊论文 Ghazi-Noori, S|Li, XJ|Sharpe, PT|Bates, GP|Li, H|Faruque, SMNN|Benn, CL|Woodman, B|Cha, JHJ|Olson, JM|Sathasivam, K|Hockly, E|Li, SH|Strand, AD|Landles, C|
44 Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat 期刊论文 Zhang, Y|Li, XJ|Shen, JY|Liao, M|Li, H|Li, SH|
45 Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin 期刊论文 Cheng, AL|Li, XJ|Li, H|Li, SH|
46 亨廷顿蛋白相关蛋白1在成年大鼠脊髓中的分布 期刊论文 许晓源|张亦农|李和|
47 HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a hd pancreatic β cell model 期刊论文 Li, He|Ye, Cui-Fang|
48 链脲佐菌素敏感的胰岛细胞表达亨廷顿蛋白相关蛋白1 期刊论文 郭剑锋|陈樱花|陈小伟|刘晶晶|李和|廖敏|张亦农|陈星星|
49 热休克蛋白40和热休克蛋白70抑制N2a细胞内突变亨廷顿蛋白聚集和毒性 期刊论文 叶翠芳|李和|
50 Effects of Mutant Huntingtin on mGluR5-Mediated Dual Signaling Pathways: Implications for Therapeutic Interventions 期刊论文 Li, He|Zhao, Dong-Ming|Huang, Shan-Shan|He, Jun|Tan, Hui-Ping|Xu, Xiao-Yuan|
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