基于调节GABA/ Glu系统平衡研究TSPO配体YL-IPA08的抗PTSD作用机制
81773708
2017
H3501.神经精神药物药理
张黎明
面上项目
副研究员
中国人民解放军军事科学院军事医学研究院
52万元
创伤后应激障碍;γ-氨基丁酸;神经类固醇;18KDa转位蛋白;谷氨酸
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Translocator protein-mediated fast-onset antidepressant-like and memory-enhancing effects in chronically stressed mice | 期刊论文 | Shang Chao;Yao Ru-Meng;Guo Ying;Ding Zhen-Chun;Sun Li-Jun;Ran Yu-Hua;Xue Rui;Wang Huai-Shan;Zhang Jian-Min;Zhang You-Zhi;Zhang Li-Ming;Li Yun-Feng |
| 2 | Serotonergic transmission is required for the anxiolytic-like behavioral effects of YL-IPA08, a selective ligand targeting TSPO | 期刊论文 | Yao Jun-Qi;Liu Chang;Jin Zeng-Liang;Liu Yan-Qin;Yin Yong-Yu;Fang Xin-Xin;Ran Yu-Hua;Zhang Li-Ming;Li Yun-Feng |
| 3 | Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function | 期刊论文 | Shang Chao;Guo Ying;Yao Jun-Qi;Fang Xin-Xin;Sun Li-Jun;Jiang Xiang-Yun;Ding Zhen-Chun;Ran Yu-Hua;Wang Heng-lin;Zhang Li-Ming;Li Yun-Feng |
| 4 | 5-HT6 receptor agonist and memory-enhancing properties of hypidone hydrochloride (YL-0919), a novel 5-HT1A receptor partial agonist and SSRI | 期刊论文 | Chen Xiao-fei;Jin Zeng-liang;Gong Ying;Zhao Nan;Wang Xiao-yun;Ran Yu-hua;Zhang You-zhi;Zhang Li-ming;Li Yun-Feng |
| 5 | The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants | 期刊论文 | Yong-Yu Yin;Yun-Hui Wang;Wen-Gang Liu;Jun-Qi Yao;Jin Yuan;Ze-Han Li;Yu-Hua Ran;Li-Ming Zhang;Yun-Feng Li |
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