代谢型谷氨酸受体3（Grm3)在自身反应性记忆B细胞中的功能研究
81471529
2014
H1102.免疫应答异常
王仁喜
面上项目
教授
中国人民解放军军事科学院军事医学研究院
70万元
自身免疫;免疫抑制;B细胞;免疫治疗;细胞因子
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. | 期刊论文 | Liu Xiaoling;Zhang Yu;Wang Zhiding;Wang Xiaoqian;Zhu Gaizhi;Han Gencheng;Chen Guojiang;Hou Chunmei;Wang Tianxiao;Shen Beifen;Li Yan;Ma Ning;Xiao He;Wang Renxi |
| 2 | AntiIL39 (IL23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupuslike mice. | 期刊论文 | Wang Xiaoqian;Zhang Yu;Wang Zhiding;Liu Xiaoling;Zhu Gaizhi;Han Gencheng;Chen Guojiang;Hou Chunmei;Wang Tianxiao;Shen Beifen;Li Yan;Xiao He;Ma Ning;Wang Renxi |
| 3 | Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. | 期刊论文 | Wang Xiaoqian;Xiao He;Wei Yinxiang;Liu Xiaoling;Han Gencheng;Chen Guojiang;Hou Chunmei;Shen Beifen;Li Yan;Wang Renxi |
| 4 | IL-15-secreting gammadeltaT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. | 期刊论文 | Wang Xiaoqian;Wei Yinxiang;Liu Xiaoling;Xing Chen;Han Gencheng;Chen Guojiang;Hou Chunmei;Dambuza Ivy M;Shen Beifen;Li Yan;Xiao He;Wang Renxi |
| 5 | The role of C5a in acute lung injury induced by highly pathogenic viral infections. | 期刊论文 | Wang Renxi;Xiao He;Guo Renfeng;Li Yan;Shen Beifen |
| 6 | 一种基于DNAH5基因的结肠癌诊断试剂盒 | 专利 | 侯春梅;韩根成;陈国江;王仁喜;肖鹤;黎燕;冯健男;沈倍奋 |
| 7 | P19/Ebi3复合物及其多克隆抗体在系统性红斑狼疮诊治中的应用 | 专利 | 王仁喜;肖鹤;韩根成;陈国江;黎燕;沈倍奋;侯春梅;王小茜;魏寅祥;刘晓玲;张玉 |
| 8 | 人白介素-1受体拮抗剂的新用途 | 专利 | 陈国江;韩根成;黎燕;沈倍奋;洪海燕;王仁喜;肖鹤;王一;王柯;侯春梅 |
| 9 | 一种获得自身反应性B细胞的方法 | 专利 | 王仁喜;黎燕;肖鹤;韩根成;陈国江;侯春梅;沈倍奋;马宁;邢陈 |
| 10 | 血清中可溶性Tim-3蛋白作为诊断慢性肾病的标志物 | 专利 | 韩根成;陈国江;石新慧;王海滨;肖燕;谢晓玮;肖鹤;王仁喜;王位;冯健男;黎燕;沈倍奋 |
| 11 | 雌二醇体外诱导对调节性B细胞分泌IL-10的影响 | 期刊论文 | 李娜;魏寅祥;侯春梅;韩根成;陈国江;沈倍奋;冯健男;黎燕;王仁喜;肖鹤 |
| 12 | Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2. | 期刊论文 | Wang Zhiding;Sun Dejun;Chen Guojiang;Li Ge;Dou Shuaijie;Wang Renxi;Xiao He;Hou Chunmei;Li Yan;Feng Jiannan;Shen Beifen;Han Gencheng |
| 13 | 一种检测TIM-3试剂盒及其使用方法 | 专利 | 韩根成;陈国江;康春燕;肖燕;谢晓玮;王仁喜;郎小玲;肖鹤;侯春梅;冯健男;蒋兴伟;赵智;黎燕;沈倍奋 |
| 14 | 雌激素对实验性自身免疫性脑脊髓炎的保护作用 | 期刊论文 | 李娜;李金亮;魏寅祥;韩根成;陈国江;侯春梅;黎燕;王仁喜;肖鹤 |
| 15 | Both Notch1 and its ligands in B cells promote antibody production | 期刊论文 | Gaizhi Zhu;Xiaoqian Wang;He Xiao;Xiaoling Liu;Ying Fang;Bing Zhai;Ruonan Xu;Gencheng Han;Guojiang Chen;Chunmei Hou;Beifen Shen;Yan Li;Ning Ma;Haitao Wu;Guangchao Liu;Renxi Wang |
| 16 | A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice. | 期刊论文 | Wang Xiaoqian;Wei Yinxiang;Xiao He;Liu Xiaoling;Zhang Yu;Han Gencheng;Chen Guojiang;Hou Chunmei;Ma Ning;Shen Beifen;Li Yan;Egwuagu Charles E;Wang Renxi |
| 17 | Pre-existing CD19-independent GL7 Breg cells are expanded during inflammation and in mice with lupus-like disease. | 期刊论文 | Wang Xiaoqian;Wei Yinxiang;Xiao He;Liu Xiaoling;Zhang Yu;Han Gencheng;Chen Guojiang;Hou Chunmei;Zhang Li;Ma Ning;Shen Beifen;Li Yan;Egwuagu Charles E;Wang Renxi |
| 18 | 一种能阻断Tim-3信号通路的人Tim-3融合蛋白 | 专利 | 韩根成;陈国江;蒋兴伟;王仁喜;肖鹤;侯春梅;于佳卉;赵智;冯健男;黎燕;沈倍奋 |
| 19 | 一种治疗多发性硬化的药物组合物 | 专利 | 王仁喜;黎燕;肖鹤;韩根成;陈国江;侯春梅;沈倍奋;马宁;邢陈 |
| 20 | Human Tim-3 fusion protein capable of blocking Tim-3 signaling pathway | 专利 | GEN CHENG HAN;Guo Jiang Chen;Xing Wei Jiang;Renxi Wang;He Xiao;Chunmei Hou;Jia Hui Yu;Zhi Zhao;JIAN NAN FENG;Yan Li;Bei Fen Shen |
| 21 | Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells | 期刊论文 | Gaizhi Zhu;Xiaoling Liu;Ying Fang;Bing Zhai;Ruonan Xu;Gencheng Han;Guojiang Chen;He Xiao;Chunmei Hou;Beifen Shen;Yan Li;Yoichiro Iwakura;Liang Wang;Zhenyu Jiang;Ning Ma;Guangchao Liu;Renxi Wang |
| 22 | 雌激素对实验性自身免疫性脑脊髓炎免疫性保护机制的研究进展 | 期刊论文 | 李娜;王仁喜;肖鹤 |
| 23 | 富马酸二甲酯在多发性硬化中的应用及其机制研究进展 | 期刊论文 | 李娜;李金亮;王仁喜;肖鹤 |
| 24 | Foxd3 suppresses IL-10 expression in B cells. | 期刊论文 | Zhang Yu;Wang Zhiding;Xiao He;Liu Xiaoling;Zhu Gaizhi;Yu Dandan;Han Gencheng;Chen Guojiang;Hou Chunmei;Ma Ning;Shen Beifen;Li Yan;Wang Tianxiao;Wang Renxi |
| 25 | B cells regulate thymic CD8(+)T cell differentiation in lupus-prone mice. | 期刊论文 | Xing Chen;Zhu Gaizhi;Xiao He;Fang Ying;Liu Xiaoling;Han Gencheng;Chen Guojiang;Hou Chunmei;Shen Beifen;Li Yan;Ma Ning;Wang Renxi |
| 26 | Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells | 期刊论文 | Ning Ma;Xiaoling Liu;Chen Xing;Xiaoqian Wang;Yinxiang Wei;Gencheng Han;Guojiang Chen;Chunmei Hou;Beifen Shen;Yan Li;He Xiao;Renxi Wang |
| 27 | Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. | 期刊论文 | Xing Chen;Ma Ning;Xiao He;Wang Xiaoqian;Zheng Mingke;Han Gencheng;Chen Guojiang;Hou Chunmei;Shen Beifen;Li Yan;Wang Renxi |
| 28 | B cell activating factor (BAFF) selects IL-10−B cells over IL-10+B cells during inflammatory responses | 期刊论文 | Ning Ma;Yu Zhang;Qilin Liu;Zhiding Wang;Xiaoling Liu;Gaizhi Zhu;Dandan Yu;Gencheng Han;Guojiang Chen;Chunmei Hou;Tianxiao Wang;Yuanfang Ma;Beifen Shen;Yan Li;He Xiao;Renxi Wang |
| 29 | Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. | 期刊论文 | Jiang Xingwei;Zhou Tingting;Xiao Yan;Yu Jiahui;Dou Shuaijie;Chen Guojiang;Wang Renxi;Xiao He;Hou Chunmei;Wang Wei;Shi Qingzhu;Feng Jiannan;Ma Yuanfang;Shen Beifen;Li Yan;Han Gencheng |
| 30 | Interleukin (IL)-39 [IL-23p19/Epstein-Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. | 期刊论文 | Wang X;Liu X;Zhang Y;Wang Z;Zhu G;Han G;Chen G;Hou C;Wang T;Ma N;Shen B;Li Y;Xiao H;Wang R |
| 31 | CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells. | 期刊论文 | Zhang Yu;Zhu Gaizhi;Xiao He;Liu Xiaoling;Han Gencheng;Chen Guojiang;Hou Chunmei;Shen Beifen;Li Yan;Ma Ning;Wang Renxi |
| 32 | IL-12家族在自身免疫性疾病中的免疫调节作用 | 期刊论文 | 王小茜;邢陈;黎燕;沈倍奋;王仁喜 |
| 33 | 一种治疗系统性红斑狼疮的药物组合物 | 专利 | 王仁喜;黎燕;肖鹤;韩根成;陈国江;侯春梅;沈倍奋;马宁;邢陈 |
| 34 | Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells. | 期刊论文 | Wei Yinxiang;Zhang Fanghui;Zhang Yu;Wang Xiaoqian;Xing Chen;Guo Jing;Zhang Hui;Suo Zhimin;Li Yan;Wang Jianli;Wang Renxi;Cai Zhijian |
| 35 | BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription. | 期刊论文 | Xu Ruonan;Fang Ying;Hou Chunmei;Zhai Bing;Jiang Zhenyu;Ma Ning;Wang Liang;Han Gencheng;Wang Renxi |
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