抗HIV-1新型N肽融合抑制剂设计、合成及其性能研究

81373266
2013
H3401.合成药物化学
刘克良
面上项目
研究员
中国人民解放军军事科学院军事医学研究院
110万元
多肽;包膜糖蛋白;艾滋病;人免疫缺陷病毒;融合抑制剂
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection 期刊论文 Chao Wang;Xue Li;Fei Yu;Lu Lu;Xifeng Jiang;Xiaoyu Xu;Huixin Wang;Wenqing Lai;Tianhong Zhang;Zhenqing Zhang;Ling Ye;Shibo Jiang;Keliang Liu
2 以gp41为靶标的小分子-多肽缀合物作为HIV-1融合抑制剂的设计、 合成及活性初筛 期刊论文 梁国栋;王潮;史卫国;王昆;姜喜凤;许笑宇;刘克良
3 Design, Synthesis and Activity Screening of Isopeptide Bond-tethered N Peptides as HIV-1 Fusion Inhibitors. 期刊论文 李雪;来文庆;姜喜凤;王潮;刘克良
4 Histidine-enriched multifunctional peptide vectors with enhanced cellular uptake and endosomal escape for gene delivery 期刊论文 Zhao Meng;Liang Luan;Ziyao Kang;Siliang Feng;Qingbin Meng;Keliang Liu
5 A novel bispecific peptide HIV‑1 fusion inhibitor targeting the N‑terminal heptad repeat and fusion peptide domains in gp41 期刊论文 Xifeng Jiang;Qiyan Jia;Lu Lu;Fei Yu;Jishen Zheng;Weiguo Shi;Lifeng Cai;Shibo Jiang;Keliang Liu
6 Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat-C-terminal heptad repeat interactions and C-peptides' anti-HIV activity 期刊论文 Baohua Zheng;Kun Wang;Lu Lu;Fei Yu;Maosheng Cheng;Shibo Jiang;Lifeng Cai;Keliang Liu
7 新型抗HIV感染多肽及其利用 专利 刘克良;蔡利锋;郑保华;张贵英;曹德强;姜喜凤
8 共价交联的N肽抑制剂 专利 刘克良;王潮;来文庆;姜喜凤;许笑宇
9 一种三萜-多肽缀合物、其药物组合物及用途 专利 刘克良;王潮;娜荷芽;姜喜凤;许笑宇
10 胆固醇修饰的非天然HR序列肽类HIV-1融合抑制剂的合成及活性初筛 期刊论文 张沙;史卫国;王潮;蔡利锋;郑保华;王昆;冯思良;贾启燕;刘克良
11 Nanostructures from the self-assembly of α-helical peptide amphiphiles 期刊论文 Qinbin Meng;Yingying Kou;Xin Ma;Lei Guo;Keliang Liu
12 Precisely Designed Isopeptide Bridge-Crosslinking Endows Artificial Hydrolases with High Stability and Catalytic Activity under Extreme Denaturing Conditions 期刊论文 Yu Bai;Chao Wang;Guodong Liang;Wenqing Lai;Huifang Xue;Yanbo Ling;Maosheng Cheng;Keliang Liu
13 An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications 期刊论文 Wenqing Lai;Chao Wang;Fei Yu;Lu Lu;Qian Wang;Xifeng Jiang;Xiaoyu Xu;Tianhong Zhang;Shengming Wu;Xi Zheng;Zhenqing Zhang;Fangting Dong;Shibo Jiang;Keliang Liu
14 异肽键稳定的MERS-CoV 融合蛋白S2亚基N端重复序列三股α螺旋的构建 期刊论文 郑汐;梁国栋;王潮;刘克良
15 五环三萜-肽缀合物、其制备方法、药物组合物及用途 专利 刘克良;娜荷芽;李相鹏;王晨宏
16 De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics 期刊论文 Chao Wang;Wenqing Lai;Fei Yu;Tianhong Zhang;Lu Lu;Xifeng Jiang;Zhenqing Zhang;Xiaoyu Xu;Yu Bai;Shibo Jiang;Keliang Liu
17 定点共价交联的天然N肽类的HIV-1抑制剂 专利 刘克良;王潮;来文庆;姜喜凤;许笑宇
18 Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains. 期刊论文 Chao Wang;Weiguo Shi;Lifeng Cai;Lu Lu;Fei Yu;Qian Wang;Xifeng Jiang;Xiaoyu Xu;Kun Wang;Liang Xu;Shibo Jiang;Keliang Liu
19 Triterpene sapogenin-polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains. 期刊论文 Heiya Na;Xiangpeng Li;Cunbin Zou;Chenhong Wang;Chao Wang;Keliang Liu
20 基于α螺旋肽与多酚缀合的HIV-1融合抑制剂的设计、合成及活性初筛 期刊论文 程思绮;梁国栋;姜喜凤;王潮;刘克良
21 多肽类核酸载体、其制备方法及用途 专利 刘克良;栾亮;徐亮;孟庆斌;许笑宇;贾启燕
22 Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor: A Promising Strategy for Discovering New Antiviral Therapeutics. 期刊论文 Chao Wang;Lu Lu;Heya Na;Xiangpeng Li;Qian Wang;Xifeng Jiang;Xiaoyu Xu;Fei Yu;Tianhong Zhang;Jinglai Li;Zhenqing Zhang;Baohua Zheng;Guodong Liang;Lifeng Cai;Shibo Jiang;Keliang Liu
23 An effective conjugation strategy for designing short peptide-based HIV-1 fusion inhibitors. 期刊论文 Guodong Liang;Huixin Wang;Huihui Chong;Siqi Cheng;Xifeng Jiang;Yuxian He;Chao Wang;Keliang Liu
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