端粒和癌基因启动子G-四链体特异性的靶向药物的单分子研究

21708009
2017
B0702.生物分子的化学生物学
游慧娟
青年科学基金项目
教授
华中科技大学
23万元
抗肿瘤;G-四链体;单分子力谱;生物大分子相互作用;核酸高级结构
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The Mechanical Properties of RNA-DNA Hybrid Duplex Stretched by Magnetic Tweezers 期刊论文 Zhang Chen;Fu Hang;Yang Yajun;Zhou Erchi;Tan Zhijie;You Huijuan;Zhang Xinghua
2 Single-Molecule Mechanical Unfolding of AT-Rich Chromosomal Fragile Site DNA Hairpins: Resolving the Thermodynamic and Kinetic Effects of a Single GT Mismatch 期刊论文 Li Xiong;Pei Yufeng;Zhang Yashuo;Liu Yajun;Fu Wenhao;Li Jixi;You Huijuan;Huang Jinqing
3 Detecting the Formation Kinetics of Doxorubicin-DNA Interstrand Cross-link at the Single-Molecule Level and Clinically Relevant Concentrations of Doxorubicin 期刊论文 Pei Yufeng;Liu Yajun;Xie Chunyu;Zhang Xinghua;You Huijuan
4 Two-State Folding Energy Determination Based on Transition Points in Nonequilibrium Single-Molecule Experiments 期刊论文 You Huijuan;Guo Shiwen;Le Shimin;Tang Qingnan;Yao Mingxi;Zhao Xiaodan;Yan Jie
5 Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene 期刊论文 Cheng Yuanlei;Tang Qingnan;Li Yutong;Zhang Yashuo;Zhao Chuyuan;Yan Jie;You Huijuan
6 ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia 期刊论文 Tong Qingyi;You Huijuan;Chen Xintao;Wang Kongchao;Sun Weiguang;Pei Yufeng;Zhao Xiaodan;Yuan Ming;Zhu Hucheng;Luo Zengwei;Zhang Yonghui
7 High Mechanical Stability and Slow Unfolding Rates Are Prevalent in Parallel-Stranded DNA G-Quadruplexes. 期刊论文 Cheng Yuanlei;Zhang Yashuo;Gong Zhou;Zhang Xinghua;Li Yutong;Shi Xiangqian;Pei Yufeng;You Huijuan
8 RNA Remodeling Proteins 专著 You Huijuan;Zhou Yu;Yan Jie
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