以IL-17信号中SHP-2/Act1相互作用界面为靶标的新型免疫炎症调控

81330079
2013
H3504.抗炎与免疫药物药理
徐强
重点项目
教授
南京大学
290万元
药学活性分子调控;SHP-2/Act1相互作用;免疫炎症;IL-17信号;药物靶标
2014-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Distinct pharmacological activities of small molecule compounds and their underlying new molecular events 会议论文 Qiang Xu
2 Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer 期刊论文 Guo Wenjie;Sun Yang;Liu Wen;Wu Xingxin;Guo Lele;Cai Peifen;Wu Xuefeng;Wu Xudong;Shen Yan;Shu Yongqian;Gu Yanhong;Xu Qiang
3 Inducible SHP-2 activation confers resistance to imatinib in drug-tolerant chronic myeloid leukemia cells. 期刊论文 Li Xin;Pang Juan;Xue Wenwen;Wang Yixuan;Tian Tian;Elgehama Ahmed;Wu Xuefeng;Wu Xudong;Sun Yang;Qiu Hongxia;Shen Yan;Xu Qiang
4 Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells 期刊论文 Gao Jian;Fan Minmin;Xiang Gang;Wang Jujuan;Zhang Xiong;Guo Wenjie;Wu Xuefeng;Sun Yang;Gu Yanhong;Ge Huiming;Tan Renxiang;Qiu Hongxia;Shen Yan;Xu Qiang
5 Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer 期刊论文 Gao Jian;Fan Minmin;Peng Shuang;Zhang Minxia;Xiang Gang;Li Xin;Guo Wenjie;Sun Yang;Wu Xuefeng;Wu Xudong;Liang Guang;Shen Yan;Xu Qiang
6 Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice 期刊论文 Luo Qiong;Sun Yang;Gong Fang-Yuan;Liu Wen;Zheng Wei;Shen Yan;Hua Zi-Chun;Xu Qiang
7 Small molecule-mediated upregulation of CCR7 ameliorates murine experimental autoimmune encephalomyelitis by accelerating T-cell homing 期刊论文 Li Xin;Lu Tingting;Xue Wenwen;Wang Yixuan;Luo Qiong;Ge Huiming;Tan Renxiang;Shen Yan;Xu Qiang
8 Small molecules with unique anti-inflmmatory effects for the prevention of colitis-associated cancer 会议论文 Qiang Xu Yang Sun Yan Shen Xudong Wu;Xuefeng Wu Xingxin Wu Qiong Luo
9 基于小分子化合物的调控磷酸酶SHP-2 作用发现SHP-2的新功能 会议论文 徐强;吴兴新;罗琼;郭文洁;孙洋;谭仁祥
10 Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88 期刊论文 Shao Fenli;Tan Tao;Tan Yang;Sun Yang;Wu Xingxin;Xu Qiang
11 SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca2+-ATPase 2 期刊论文 Li W.;Ouyang Z.;Zhang Q.;Wang L.;Shen Y.;Wu X.;Gu Y.;Shu Y.;Yu B.;Wu X.;Sun Y.;Xu Q.
12 A novel combination of astilbin and low-dose methotrexate respectively targeting A(2A)AR and its ligand adenosine for the treatment of collagen-induced arthritis 期刊论文 Ma Yuxiang;Gao Zhe;Xu Fang;Liu Li;Luo Qiong;Shen Yan;Wu Xuefeng;Wu Xingxin;Sun Yang;Wu Xudong;Xu Qiong
13 TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells 期刊论文 Hu Yamei;Li Xin;Xue Wenwen;Pang Juan;Meng Yiwei;Shen Yan;Xu Qiang
14 炎症及相关疾病治疗的新靶点和新策略研究 奖励 徐强;郭文洁;孙洋;吴雪丰;吴兴新;罗琼;沈燕;刘雯
15 Inhibition of autophagy by andrographolide resensitizes cisplatin-resistant non-small cell lung carcinoma cells via activation of the Akt/mTOR pathway 期刊论文 Mi Shanwei;Xiang Gang;Yuwen Daolu;Gao Jian;Guo Wenjie;Wu Xuefeng;Wu Xudong;Sun Yang;Su Yongqian;Shen Yan;Xu Qiang
16 Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies 期刊论文 Zou Yi;Wang Fang;Wang Yan;Sun Qirui;Hu Yue;Li Yuezhen;Liu Wen;Guo Wenjie;Huang Zhangjian;Zhang Yihua;Xu Qiang;Lai Yisheng
17 A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide 期刊论文 Luo Qiong;Sun Yang;Liu Wen;Qian Cheng;Jin Biao;Tao Feifei;Gu Yanhong;Wu Xingxin;Shen Yan;Xu Qiang
18 Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid Astilbin 期刊论文 Guo Lele;Liu Wen;Lu Tingting;Guo Wenjie;Gao Jian;Luo Qiong;Wu Xuefeng;Sun Yang;Wu Xudong;Shen Yan;Xu Qiang
19 A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation 期刊论文 Wang Xingqi;Wang Shiyu;Hu Chunhui;Chen Wei;Shen Yan;Wu Xuefeng;Sun Yang;Xu Qiang
20 Characteristics of some compounds and their mechanisms against immunoinflammation 会议论文 Qiang Xu
21 A natural compound jaceosidin ameliorates endoplasmic reticulum stress and insulin resistance via upregulation of SERCA2b 期刊论文 Ouyang Zijun;Li Wanshuai;Meng Qianqian;Zhang Qi;Wang Xingqi;Elgehama Ahmed;Wu Xudong;Shen Yan;Sun Yang;Wu Xuefeng;Xu Qiang
22 黄柏内酯在制备治疗肺纤维化、慢性肺炎、慢性呼吸道疾病药物中的应用及其药物 专利 徐强;吴雪丰;孙洋;王兴启;沈燕;吴旭东;罗琼;金彪
23 Spandidos publications Award for an Outstanding Achievement 奖励 Qiang Xu
24 Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells 期刊论文 Elgehama Ahmed;Chen Wei;Pang Juan;Mi Shanwei;Li Jiahuang;Guo Wenjie;Wang Xingqi;Gao Jian;Yu Biao;Shen Yan;Xu Qiang
25 Trichomide A, a Natural Cyclodepsipeptide, Exerts Immunosuppressive Activity against Activated T Lymphocytes by Upregulating SHP2 Activation to Overcome Contact Dermatitis 期刊论文 Wang Xingqi;Zhang Aihua;Gao Jian;Chen Wei;Wang Shiyu;Wu Xuefeng;Shen Yan;Ke Yuehai;Hua Zichun;Tan Renxiang;Sun Yang;Xu Qiang
26 Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator 期刊论文 Xiang Gang;Fan Minmin;Ma Yuzhu;Wang Miao;Gao Jian;Chen Jingwei;Li Xin;Xue Wenwen;Wang Yixuan;Gao Huiyuan;Shen Yan;Xu Qiang
27 Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice 期刊论文 Liu Wen;Guo Wenjie;Zhu Yongcheng;Peng Shuang;Zheng Wei;Zhang Chao;Shao Fenli;Zhu Yuyu;Hang Nan;Kong Lingdong;Meng Xiangbao;Xu Qiang;Sun Yang
28 CUG-binding protein 1 regulates HSC activation and liver fibrogenesis 期刊论文 Wu Xingxin;Wu Xudong;Ma Yuxiang;Shao Fenli;Tan Yang;Tan Tao;Gu Liyun;Zhou Yang;Sun Beicheng;Sun Yang;Wu Xuefeng;Xu Qiang
29 Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis 期刊论文 Guo Wenjie;Liu Wen;Chen Zhen;Gu Yanhong;Peng Shuang;Shen Lihong;Shen Yan;Wang Xingqi;Feng Gen-Sheng;Sun Yang;Xu Qiang
30 小分子化合物对磷酸酶SHP-2的调控作用 会议论文 徐强
31 Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. 期刊论文 Feng Lili;Sun Yi;Song Pingping;Xu Lisha;Wu Xingxin;Wu Xuefeng;Shen Yan;Sun Yang;Kong Lingdong;Wu Xudong;Xu Qiang
32 一种治疗类风湿关节炎的联用药物 专利 徐强;吴旭东;高晢;吴雪丰
33 Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice 期刊论文 Liu Wen;Guo Wenjie;Zhu Yongcheng;Peng Shuang;Zheng Wei;Zhang Chao;Shao Fenli;Zhu Yuyu;Hang Nan;Kong Lingdong;Meng Xiangbao;Xu Qiang;Sun Yang
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