高脂诱导骨骼肌胰岛素抵抗的分子调控机制研究

81270906
2012
H0708.糖尿病
毕艳
面上项目
教授
南京大学
65万元
2型糖尿病;胆固醇调节元件结合蛋白1c;胰岛素抵抗;脂毒性;骨骼肌
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized and non-randomized studies 期刊论文 Feng, Wenhuan|Shen, Shanmei|Bi, Yan|Zhu, Dalong|
2 胰岛素通过抑制Rho激酶改善高脂诱导的骨骼肌细胞AMPK/SREBP-1c通路 会议论文 汤文娟|吴文君|朱大龙|毕艳|
3 Role for sterol regulatory element binding protein 1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription 期刊论文 Shen SM|Gao Q|Weng JP|Zhu DL|
4 Correlations between A1c, fasting glucose, 2h postload glucose, and beta-cell function in the Chinese population 期刊论文 Shen, SM|Feng, WH|Bi, Y|Zhu, DL|
5 1H-MRS定量肝脏脂肪在评估降糖药物疗效中的临床应用 奖励 毕艳|
6 Association of b-cell function and insulin sensitivity with fasting and 2h plasma glucose in a large Chinese population 奖励 毕艳|朱大龙|
7 胰岛素不同治疗时机对脂代谢的不同效应及其机制研究 会议论文 毕艳|
8 胰岛素通过降低细胞能荷改善骨骼肌脂毒性 会议论文 汤孙寅焱|王洪东|毕艳|朱大龙|
9 比较艾塞那肽、胰岛素和吡格列酮对新诊断2型糖尿病患者降糖及β细胞功能的作用：一项多中心、随机对照、平行组研究 奖励 毕艳|孙子林|纪立农|翁建平|
10 Global Epidemiology of Diabetic Foot Ulceration: A Systematic Review andMeta-Analysis. 期刊论文 Yali Jing|Sunyinyan Tang|Dalong Zhu|Yan Bi|
11 Effectsof exenatide, insulin, and pioglitazone on liver fat content and bodyfat distributions in newly-diagnosed subjects with type 2 diabetes 会议论文 毕艳|
12 Metforminattenuates palmitic acid-induced insulin resistance in L6 cells through theAMP-activated protein kinase/sterol regulatory element-binding protein-1cpathway 期刊论文 Cao S|Bu RF|Zhu DL|Bi Y|
13 固醇调节原件结合蛋白-1c激活后通过抑制大鼠胰岛素受体底物-1转录介导骨骼肌胰岛素抵抗的作用 奖励 毕艳|
14 胰岛素通过抑制Rho激酶改善高脂诱导的骨骼肌细胞AMPK/SREBP-1c通路 会议论文 葛智娟|洪汀|朱大龙|毕艳|
15 Erythropoietin via PPAR-dependent AKT activation alleviates hepatic insulin resistance 期刊论文 Hong T|Meng R|Bi Y|Zhu DL|
16 Decrement in Rho-kinase 1 and adenylate energycharge contribute to the interactive regulation of insulin and fatty acid onAMPK/SREBP-1c pathway in skeletal muscle cells 会议论文 吴文君|汤文娟|朱大龙|毕艳|
17 Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in newly-diagnosed subjects with type 2 diabetes 期刊论文 Wang X|Zhu B|Weng JP|Zhu DL|
18 Role for SREBP-1c in inducing skeletal muscle insulinresistance via repressing IRS-1 transcription and promoting inflammatoryresponse 会议论文 毕艳|
19 The beneficial effect of metformin on beta-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes 期刊论文 Xin, B.|Miao, H.|Peng, Z. H.|Zhu, D. L.|
20 糖化血红蛋白与B细胞功能的关系 期刊论文 杨慧杰|童国玉|毕艳|朱大龙|
21 降糖药物对脂肪肝作用的差异性探讨 会议论文 毕艳|
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