靶向自噬关键分子Atg4B的新型小分子化合物设计合成及其抗乳腺癌机制研究

81602953
2016
H3401.合成药物化学
张岚
青年科学基金项目
副教授
西南交通大学
17万元
自噬;Atg4B激动剂;结构优化;乳腺癌
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer 期刊论文 Ouyang Liang;Zhang Lan;Fu Leilei;Liu Bo
2 UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target 期刊论文 Zhang Lan;Ouyang Liang;Guo Yongzhi;Zhang Jin;Liu Bo
3 Targeting autophagy-related protein kinases for potential therapeutic purpose 期刊论文 Zhang Jifa;Xiang Honggang;Lin Congcong;Zhang Lan;Liu Bo;Ouyang Liang
4 Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment 期刊论文 Ouyang Liang;Zhang Lan;Zhang Shouyue;Yao Dahong;Zhao Yuqian;Wang Guan;Fu Leilei;Lei Peng;Liu Bo
5 Discovery of a small-molecule bromodomain-containing protein 4 (BRD4) inhibitor that induces AMP-activated protein kinase-modulated autophagy-associated cell death in breast cancer 期刊论文 Ouyang Liang;Zhang Lan;Liu Jie;Fu Leilei;Yao Dahong;Zhao Yuqian;Zhang Shouyue;Wang Guan;He Gu;Liu Bo
6 Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types 期刊论文 Wang Guan;Zhao Yuqian;Liu Yao;Sun Dejuan;Zhen Yongqi;Liu Jie;Fu Leilei;Zhang Lan;Ouyang Liang
7 Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo 期刊论文 Zhang Lan;Fu Leilei;Zhang Shouyue;Zhang Jin;Zhao Yuqian;Zheng Yaxin;He Gu;Yang Shengyong;Ouyang Liang;Liu Bo
8 自噬启动因子ULK1的生物学功能与靶向治疗研究进展 期刊论文 张岚;欧阳亮;刘博
9 Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells 期刊论文 Zhao Shuangmei;Zhen Yongqi;Fu Leilei;Gao Feng;Zhou Xianli;Huang Shuai;Zhang Lan
10 Diarylheptanoid: A privileged structure in drug discovery 期刊论文 Sun Dejuan;Zhu Lingjuan;Zhao Yuqian;Zhen Yongqi;Zhang Lan;Lin Congcong;Chen Lixia
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