靶向ERK新型抗乳腺癌小分子BL-EI001诱导自噬性死亡的机制研究

81602627
2016
H1821.肿瘤治疗抵抗
符雷蕾
青年科学基金项目
副教授
西南交通大学
17万元
自噬性死亡;ERK抑制剂;凋亡;C21_乳腺肿瘤;(BL-EI001);eEF2K
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Recent progress in potential anti-hepatitis B virus agents: Structural and pharmacological perspectives 期刊论文 Dejuan Sun;Lingjuan Zhu;Dahong Yao;Lixia Chen;Leilei Fu;Liang Ouyang
2 Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells. 期刊论文 Chen Yujuan;Wang Xiaoyun;Cao Chuan;Wang Xiaodong;Liang Shufang;Peng Cheng;Fu Leilei;He Gu
3 A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer 期刊论文 Ouyang Liang;Zhang Lan;Fu Leilei;Liu Bo
4 Discovery of a novel dual-target inhibitor of ERK1 and ERK5 that induces regulated cell death to overcome compensatory mechanism in specific tumor types 期刊论文 Guan Wang;Yuqian Zhao;Yao Liu;Dejuan Sun;Yongqi Zhen;Jie Liu;Leilei Fu;Lan Zhang;Liang Ouyang
5 Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. 期刊论文 Zhang Lan;Fu Leilei;Zhang Shouyue;Zhang Jin;Zhao Yuqian;Zheng Yaxin;He Gu;Yang Shengyong;Ouyang Liang;Liu Bo
6 A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma 期刊论文 Yao Zhi qiang;Zhang Xin;Zhen Yongqi;He Xu Ying;Zhao Shuangmei;Li Xi Feng;Yang Bo;Gao Feng;Guo Fu You;Fu Leilei;Liu Xian Zhi;Duan Chuan Zhi
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