非核糖体肽类天然产物生物合成中催化四种反应类型的硫酯酶催化机制和晶体结构研究
21877002
2018
B0705.生物合成化学
马明
面上项目
研究员
北京大学
68万元
硫酯酶;海洋;生物合成;天然产物;催化机制
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis | 期刊论文 | Xing Baiying;Yu Jiahui;Chi Changbiao;Ma Xueyang;Xu Qingxia;Li Annan;Ge Yuanjie;Wang Zhengdong;Liu Tan;Jia Hongli;Yin Fuling;Guo Juan;Huang Luqi;Yang Donghui;Ma Ming |
| 2 | Two glucosylated angucyclines from deep-sea-derived Streptomyces sp.PKU-MA01297 | 期刊论文 | Ma Xueyang;Wang Guiyang;Zhang Zhongyi;Geng Tongtong;Sun Xiaoxu;Yang Donghui;Tang Xixiang;Ma Ming |
| 3 | Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes | 期刊论文 | Baiying Xing;Houchao Xu;Annan Li;Tingting Lou;Meng Xu;Kaibiao Wang;Zhengren Xu;Jeroen S. Dickschat;Donghui Yang;Ming Ma |
| 4 | 环肽WS9326A生物合成中硫酯酶两个底物类似物的合成(英文) | 期刊论文 | 张中义;王翰轩;王贵阳;马学洋;刘谈;耿彤彤;孙晓旭;杨东辉;董甦伟;马明 |
| 5 | Strepimidazoles A-G from the plant endophytic Streptomyces sp. PKU-EA00015 with inhibitory activities against a plant pathogenic fungus | 期刊论文 | Sun Xiaoxu;Wang Guiyang;Xiao Hua;Jiang Jingyi;Xiao Dongliang;Xing Baiying;Li Annan;Zhang Yingtao;Sun Kai;Xu Yuquan;Guo Lanping;Yang Donghui;Ma Ming |
| 6 | Crystal structures of Fsa2 and Phm7 catalyzing [4+2] cycloaddition reactions with reverse stereoselectivities in equisetin and phomasetin biosynthesis | 期刊论文 | Chi Changbiao;Wang Zhengdong;Liu Tan;Zhang Zhongyi;Zhou Huan;Li Annan;Jin Hongwei;Jia Hongli;Yin Fuling;Yang Donghui;Ma Ming |
| 7 | 非核糖体肽Skyllamycin B生物合成中Ⅰ型硫酯酶底物杂泛性的初步研究 | 期刊论文 | 宋娟;于佳慧;李安南;关梦铁;耿彤彤;张中义;杨东辉;马明 |
| 8 | Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis | 期刊论文 | Yu Jiahui;Song Juan;Chi Changbiao;Liu Tan;Geng Tongtong;Cai Zonghui;Dong Weidong;Shi Cheng;Ma Xueyang;Zhang Zhongyi;Ma Xiaojie;Xing Baiying;Jin Hongwei;Zhang Liangren;Dong Suwei;Yang Donghui;Ma Ming |
| 9 | Structural insight into a metal-dependent mutase revealing an arginine residue-covalently mediated interconversion between nucleotide-based pyranose and furanose | 期刊论文 | Chichang Biao;Run Xu;Qianqian Chen;Xiaohui Zhang;Xiaomeng Shi;Hongwei Jin;Fuling Yin;Hongli Jia;Liangren Zhang;Donghui Yang;Jianhua Ju;Qinglian Li;Ming Ma |
| 10 | Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications | 期刊论文 | Liu Tan;Ma Xiaojie;Yu Jiahui;Yang Wensheng;Wang Guiyang;Wang Zhengdong;Ge Yuanjie;Song Juan;Han Hua;Zhang Wen;Yang Donghui;Liu Xuehui;Ma Ming |
| 11 | Discovery and biosynthesis of pepticinnamins G–M featuring three enzymes-catalyzed nonproteinogenic amino acid formation | 期刊论文 | Yuanjie Ge;Guiyang Wang;Jing Jin;Tan Liu;Xueyang Ma;Zhongyi Zhang;Tongtong Geng;Juan Song;Xiaojie Ma;Yingtao Zhang;Donghui Yang;Ming Ma |
| 12 | Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis | 期刊论文 | Ning Shao;Xueyang Ma;Ying-ying Zhang;Donghui Yang;Ming Ma;Gong-Li Tang |
| 13 | Structure-based mechanistic insights into ColB1, a flavoprotein functioning in trans in the 2,2ʹ-bipyridine assembly line for cysteine dehydrogenation | 期刊论文 | Xueyang Ma;Zhijun Tang;Wenping Ding;Tan Liu;Donghui Yang;Wen Liu;Ming Ma |
| 14 | Generation of unusual aromatic polyketides by incorporation of phenylamine analogues into a C-ring-cleaved angucyclinone | 期刊论文 | Xiao Hua;Wang Guiyang;Wang Zhengdong;Kuang Yi;Song Juan;Jin Jing;Ye Min;Yang Donghui;Ma Ming |
| 15 | Functional characterization and crystal structure of the type II peptidyl carrier protein ColA1a in collismycins biosynthesis | 期刊论文 | Ma Xueyang;Wang Guiyang;Liu Tan;Chi Changbiao;Zhang Zhongyi;Yang Donghui;Liu Wen;Ma Ming |
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