新型高活性、特异性ATM激酶抑制剂的设计、合成与生物功能研究

21772005
2017
B0706.药物化学生物学
刘振明
面上项目
研究员
北京大学
64万元
毛细血管共济失调突变激酶;DNA损伤应答;联合用药;药物分子设计;肿瘤耐药
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Multi-objective de novo drug design with conditional graph generative model 期刊论文 Li Yibo;Zhang Liangren;Liu Zhenming;Zhang LR;Liu ZM
2 Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors 期刊论文 Dou Xiaodong;Huang Huixia;Jiang Lan;Zhu Guiwang;Jin Hongwei;Jiao Ning;Zhang Liangren;Liu Zhenming;Zhang Lihe
3 Multistage Screening Reveals 3-Substituted lndolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases 期刊论文 Dou Xiaodong;Huang Huixia;Li Yibo;Jiang Lan;Wang Yanxing;Jin Hongwei;Jiao Ning;Zhang Lihe;Zhang Liangren;Liu Zhenming
4 Discovery of new GSK-3 beta inhibitors through structure-based virtual screening 期刊论文 Dou Xiaodong;Jiang Lan;Wang Yanxing;Jin Hongwei;Liu Zhenming;Zhang Liangren
5 Discovery of N-(Naphtho[1,2-b]Furan-5-Yl) Benzenesulfonamides as Novel Selective Inhibitors of Triple-Negative Breast Cancer (TNBC) 期刊论文 Chen Ya;Tang Yong;Mao Beibei;Li Wenchao;Jin Hongwei;Zhang Liangren;Liu Zhenming
6 Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening 期刊论文 Chen Ya;Yuan Xia;Xiao Zhangping;Jin Hongwei;Zhang Liangren;Liu Zhenming
7 Discovery of novel glycogen synthase kinase-3 alpha inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia 期刊论文 Wang Yanxing;Dou Xiaodong;Jiang Lan;Jin Hongwei;Zhang Lihe;Zhang Liangren;Liu Zhenming
8 TF3P: Three-Dimensional Force Fields Fingerprint Learned by Deep Capsular Network 期刊论文 Wang Yanxing;Hu Jianxing;Lai Junyong;Li Yibo;Jin Hongwei;Zhang Lihe;Zhang Liang-Ren;Liu Zhen-ming
9 Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL 期刊论文 Yang Lixin;Liu Yongqing;Fan Minghua;Zhu Guiwang;Jin Hongwei;Liang Jing;Liu Zhenming;Huang Zhuo;Zhang Liangren
10 Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation 期刊论文 Jiao Peili;Wang Yuxi;Mao Beibei;Wang Bingding;Zhong Yi;Jin Hongwei;Zhang Lihe;Zhang Liangren;Liu Zhenming
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